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H2-T24 histocompatibility 2, T region locus 24 [ Mus musculus (house mouse) ]

Gene ID: 15042, updated on 2-Nov-2024

Summary

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Official Symbol
H2-T24provided by MGI
Official Full Name
histocompatibility 2, T region locus 24provided by MGI
Primary source
MGI:MGI:95958
See related
Ensembl:ENSMUSG00000053835 AllianceGenome:MGI:95958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2T24
Summary
Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 11.8), thymus adult (RPKM 8.7) and 26 other tissues See more
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Genomic context

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See H2-T24 in Genome Data Viewer
Location:
17 B1; 17 18.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36314363..36331689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36003471..36020800, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8674 Neighboring gene predicted gene, 32655 Neighboring gene proline-rich polypeptide 3 Neighboring gene guanine nucleotide binding protein-like 1 Neighboring gene RIKEN cDNA A930015D03 gene Neighboring gene STARR-positive B cell enhancer ABC_E5609 Neighboring gene STARR-positive B cell enhancer ABC_E8921 Neighboring gene STARR-positive B cell enhancer ABC_E959 Neighboring gene STARR-positive B cell enhancer ABC_E4214 Neighboring gene STARR-positive B cell enhancer ABC_E5610 Neighboring gene STARR-positive B cell enhancer ABC_E9951 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36157683-36157870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36160698-36160881 Neighboring gene STARR-positive B cell enhancer ABC_E8675 Neighboring gene histocompatibility 2, T region locus 23 Neighboring gene STARR-positive B cell enhancer ABC_E168 Neighboring gene histocompatibility 2, T region locus 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic organization and sequence of the H2-T24 gene. Crew MD, et al. Immunogenetics, 1999 Jul. PMID 10369932
  2. H-2T24 and PemaT24: orthologous expressed MHC class Ib genes from mouse and Peromyscus maniculatus. Crew MD, et al. Immunogenetics, 1994. PMID 8188318
  3. Fine map of a region homologous to the rat grc complex in the TL region of the mouse. Hunt SW 3rd, et al. Immunogenetics, 1993. PMID 8428772
  4. Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse. Brorson KA, et al. J Exp Med, 1989 Dec 1. PMID 2584927, Free PMC Article
  5. Genetic and molecular mapping of the Hmt region of mouse. Richards S, et al. EMBO J, 1989 Dec 1. PMID 2573520, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histocompatibility 2, T region locus 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008207.3 → NP_032233.2  histocompatibility 2, T region locus 24 precursor

    See identical proteins and their annotated locations for NP_032233.2

    Status: VALIDATED

    Source sequence(s)
    AC112970
    Consensus CDS
    CCDS37607.1
    UniProtKB/TrEMBL
    F8VQG4, Q9XRZ3
    Related
    ENSMUSP00000109389.4, ENSMUST00000113760.10
    Conserved Domains (2) summary
    cd07698
    Location:208 → 300
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:19 → 203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36314363..36331689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939469.1 RNA Sequence

  2. XR_004939470.1 RNA Sequence

  3. XR_004939468.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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