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RNF145 ring finger protein 145 [ Homo sapiens (human) ]

Gene ID: 153830, updated on 2-Nov-2024

Summary

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Official Symbol
RNF145provided by HGNC
Official Full Name
ring finger protein 145provided by HGNC
Primary source
HGNC:HGNC:20853
See related
Ensembl:ENSG00000145860 MIM:620640; AllianceGenome:HGNC:20853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung (RPKM 33.4), gall bladder (RPKM 23.7) and 24 other tissues See more
Orthologs
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Genomic context

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See RNF145 in Genome Data Viewer
Location:
5q33.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (159157409..159210053, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (159686225..159738515, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (158584417..158637061, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr5:158124779-158125433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158139245-158139745 Neighboring gene VISTA enhancer hs813 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158164501-158165077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16566 Neighboring gene EBF transcription factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23536 Neighboring gene VISTA enhancer hs230 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158378905-158379562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23537 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:158384828-158385690 Neighboring gene NANOG hESC enhancer GRCh37_chr5:158403034-158403551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16567 Neighboring gene VISTA enhancer hs1022 Neighboring gene VISTA enhancer hs1117 Neighboring gene VISTA enhancer hs1123 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:158522773-158523666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158524561-158525454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158527833-158528459 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:158527204-158527832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:158531040-158531945 Neighboring gene uncharacterized LOC107986467 Neighboring gene long intergenic non-protein coding RNA 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23540 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:158588140-158589339 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158634672-158635327 Neighboring gene uncharacterized LOC107986468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23544 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene long intergenic non-protein coding RNA 1932 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158689523-158690030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158690031-158690538 Neighboring gene ubiquitin like domain containing CTD phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China. Ming J, et al. Sci Rep, 2021 Mar 16. PMID 33727652, Free PMC Article
  2. CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway. Rong L, et al. J Transl Med, 2022 Apr 1. PMID 35365168, Free PMC Article
  3. Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase. Jiang LY, et al. J Biol Chem, 2018 Mar 16. PMID 29374057, Free PMC Article
  4. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Soranzo N, et al. Nat Genet, 2009 Nov. PMID 19820697, Free PMC Article
  5. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFkappaB signaling pathway.
    Title: CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway.
  2. Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China.
    Title: Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
EBI GWAS Catalog
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31951, FLJ44310, DKFZp686M11215

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger protein 145
NP_001186309.1
NP_001186310.1
NP_001186311.1
NP_001186312.1
NP_653327.1
XP_016864627.1
XP_024310151.1
XP_054207831.1
XP_054207832.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199380.2 → NP_001186309.1  RING finger protein 145 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK308394, AL831829, BC042684
    Consensus CDS
    CCDS56393.1
    UniProtKB/TrEMBL
    A8K9Y9
    Related
    ENSP00000430955.1, ENST00000518802.5
    Conserved Domains (3) summary
    pfam12678
    Location:564 → 605
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:565 → 605
    zf-RING_2; Ring finger domain
    pfam13705
    Location:38 → 536
    TRC8_N; TRC8 N-terminal domain

  2. NM_001199381.2 → NP_001186310.1  RING finger protein 145 isoform 3

    See identical proteins and their annotated locations for NP_001186310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK304435, AL697229, AL831829
    Consensus CDS
    CCDS56392.1
    UniProtKB/TrEMBL
    A8K9Y9
    Related
    ENSP00000430753.2, ENST00000521606.6
    Conserved Domains (3) summary
    pfam12678
    Location:551 → 592
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:552 → 592
    zf-RING_2; Ring finger domain
    pfam13705
    Location:25 → 523
    TRC8_N; TRC8 N-terminal domain

  3. NM_001199382.2 → NP_001186311.1  RING finger protein 145 isoform 4

    See identical proteins and their annotated locations for NP_001186311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 1. The resulting isoform (4) lacks a segment in the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK304228, AL831829, BC042684, DC418555
    Consensus CDS
    CCDS56391.1
    UniProtKB/TrEMBL
    A8K9Y9
    Related
    ENSP00000429071.1, ENST00000520638.1
    Conserved Domains (3) summary
    pfam12678
    Location:548 → 589
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:549 → 589
    zf-RING_2; Ring finger domain
    pfam13705
    Location:22 → 520
    TRC8_N; TRC8 N-terminal domain

  4. NM_001199383.2 → NP_001186312.1  RING finger protein 145 isoform 5

    See identical proteins and their annotated locations for NP_001186312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK292854, AL831829, CK821118
    Consensus CDS
    CCDS56390.1
    UniProtKB/Swiss-Prot
    B7Z903, B7Z949, E7EVI7, Q8IVP7, Q96MT1
    UniProtKB/TrEMBL
    A8K9Y9
    Related
    ENSP00000409064.2, ENST00000424310.7
    Conserved Domains (3) summary
    pfam12678
    Location:534 → 575
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:535 → 575
    zf-RING_2; Ring finger domain
    pfam13705
    Location:8 → 506
    TRC8_N; TRC8 N-terminal domain

  5. NM_144726.3 → NP_653327.1  RING finger protein 145 isoform 2

    See identical proteins and their annotated locations for NP_653327.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK056513, AL831829, BC042684
    Consensus CDS
    CCDS4344.1
    UniProtKB/TrEMBL
    A8K9Y9
    Related
    ENSP00000274542.2, ENST00000274542.6
    Conserved Domains (3) summary
    pfam12678
    Location:562 → 603
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:563 → 603
    zf-RING_2; Ring finger domain
    pfam13705
    Location:36 → 534
    TRC8_N; TRC8 N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    159157409..159210053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009138.3 → XP_016864627.1  RING finger protein 145 isoform X2

    UniProtKB/Swiss-Prot
    B7Z903, B7Z949, E7EVI7, Q8IVP7, Q96MT1
    UniProtKB/TrEMBL
    A8K9Y9
    Conserved Domains (3) summary
    pfam12678
    Location:534 → 575
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:535 → 575
    zf-RING_2; Ring finger domain
    pfam13705
    Location:8 → 506
    TRC8_N; TRC8 N-terminal domain

  2. XM_024454383.2 → XP_024310151.1  RING finger protein 145 isoform X1

    UniProtKB/TrEMBL
    A8K9Y9
    Conserved Domains (3) summary
    pfam13705
    Location:24 → 522
    TRC8_N; TRC8 N-terminal domain
    cd16684
    Location:549 → 591
    RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
    cl26329
    Location:536 → 641
    zf-rbx1; RING-H2 zinc finger domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    159686225..159738515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351857.1 → XP_054207832.1  RING finger protein 145 isoform X2

    UniProtKB/Swiss-Prot
    B7Z903, B7Z949, E7EVI7, Q8IVP7, Q96MT1

  2. XM_054351856.1 → XP_054207831.1  RING finger protein 145 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96MT1.2 GenPept UniProtKB/Swiss-Prot:Q96MT1

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