Htr2c 5-hydroxytryptamine (serotonin) receptor 2C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr2cprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 2Cprovided by MGI
Primary source: MGI:MGI:96281
See related: Ensembl:ENSMUSG00000041380 AllianceGenome:MGI:96281
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SR1; 5HT1c; Htr1c; 5-HT1C; 5-HT2C; 5-HT-1C; 5-HT-2C; 5-HT2cR; 5-HTR2C
Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]
Expression: Biased expression in cerebellum adult (RPKM 5.4), frontal lobe adult (RPKM 3.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F2; X 68.46 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (145745509..145980273)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (146962464..147197277)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans.
Title: Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans.
Effects of 5-HT2C receptor stimulation in male mice on behaviour and Fos expression: Feeding, reward and impulsivity.
Title: Effects of 5-HT(2C) receptor stimulation in male mice on behaviour and Fos expression: Feeding, reward and impulsivity.
Adverse maternal environment affects hippocampal HTR2c variant expression and epigenetic characteristics in mouse offspring.
Title: Adverse maternal environment affects hippocampal HTR2c variant expression and epigenetic characteristics in mouse offspring.
Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway.
Title: Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway.
Serotonin 5-HT2C receptor knockout in mice attenuates fear responses in contextual or cued but not compound context-cue fear conditioning.
Title: Serotonin 5-HT(2C) receptor knockout in mice attenuates fear responses in contextual or cued but not compound context-cue fear conditioning.
Galphai/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents.
Title: Gα(i/o)-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents.
RNA editing of 5-HT2C R impairs insulin secretion of pancreatic beta cells via altered store-operated calcium entry.
Title: RNA editing of 5-HT(2C) R impairs insulin secretion of pancreatic beta cells via altered store-operated calcium entry.
Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5-HT2C receptor heteromers in mouse brain.
Title: Pharmacological evidence for transactivation within melatonin MT(2) and serotonin 5-HT(2C) receptor heteromers in mouse brain.
Behavioral characteristics of 5-HT2C receptor knockout mice: Locomotor activity, anxiety-, and fear memory-related behaviors.
Title: Behavioral characteristics of 5-HT(2C) receptor knockout mice: Locomotor activity, anxiety-, and fear memory-related behaviors.
Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model.
Title: Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (92)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

30.MMHAP67FLB6.seq (e-PCR)
- UniSTS:123913

Htr2c (e-PCR), detects polymorphism
- UniSTS:143425

Htr2c (e-PCR), detects polymorphism
- UniSTS:143426

BB315810 (e-PCR)
- UniSTS:208459

G67051 (e-PCR)
- UniSTS:178260

X72230 (e-PCR)
- UniSTS:209547

PMC166422P3 (e-PCR)
- UniSTS:271596

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	IEA Inferred from Electronic Annotation more info
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables Gq/11-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables Gq/11-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serotonin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables serotonin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase D-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acetylcholine secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of corticotropin-releasing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensitization	ISO Inferred from Sequence Orthology more info
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	IEA Inferred from Electronic Annotation more info
part_of G protein-coupled serotonin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2C

Names: 5-HT2C receptor; 5-hydroxytryptamine receptor 1C; serotonin receptor 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411391.1 → NP_001398320.1 5-hydroxytryptamine receptor 2C isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL662932, AL808014, BX005219

UniProtKB/TrEMBL

S4R2T0

Related

ENSMUSP00000138772.2, ENSMUST00000156697.8
NM_008312.4 → NP_032338.3 5-hydroxytryptamine receptor 2C isoform 1 precursor

See identical proteins and their annotated locations for NP_032338.3

Status: REVIEWED

Source sequence(s)

AK034512, AK079648, BC098327

Consensus CDS

CCDS30459.1

UniProtKB/Swiss-Prot

B1ATN5, P34968, Q5WRU6

UniProtKB/TrEMBL

Q8BZI5

Related

ENSMUSP00000043936.3, ENSMUST00000036303.9

Conserved Domains (1) summary

cd15305
Location:55 → 386

7tmA_5-HT2C; serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

145745509..145980273

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251228.2 → XP_030107088.1 5-hydroxytryptamine receptor 2C isoform X1

Conserved Domains (2) summary

cd14964
Location:46 → 75

7tm_GPCRs; TM helix 5 [structural motif]

cl28897
Location:17 → 220

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily