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Htr5a 5-hydroxytryptamine (serotonin) receptor 5A [ Mus musculus (house mouse) ]

Gene ID: 15563, updated on 2-Nov-2024

Summary

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Official Symbol
Htr5aprovided by MGI
Official Full Name
5-hydroxytryptamine (serotonin) receptor 5Aprovided by MGI
Primary source
MGI:MGI:96283
See related
Ensembl:ENSMUSG00000039106 AllianceGenome:MGI:96283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Htr5
Summary
Predicted to enable Gi/o-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in perikaryon. Predicted to be active in dendrite and postsynaptic specialization membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and liver and biliary system. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 2.1), frontal lobe adult (RPKM 2.0) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Htr5a in Genome Data Viewer
Location:
5 B1; 5 13.24 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28046836..28059403)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (27841716..27855086)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3565 Neighboring gene STARR-seq mESC enhancer starr_12707 Neighboring gene STARR-seq mESC enhancer starr_12709 Neighboring gene predicted gene, 20239 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene Neighboring gene SPATA31 subfamily H, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. Plassat JL, et al. EMBO J, 1992 Dec. PMID 1464308, Free PMC Article
  2. The native serotonin 5-HT(5A) receptor: electrophysiological characterization in rodent cortex and 5-HT(1A)-mediated compensatory plasticity in the knock-out mouse. Goodfellow NM, et al. J Neurosci, 2012 Apr 25. PMID 22539842, Free PMC Article
  3. Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Grailhe R, et al. Neuron, 1999 Mar. PMID 10197537
  4. Cortisol regulates immune and metabolic processes in murine adipocytes and macrophages through HTR2c and HTR5a serotonin receptors. Priyadarshini S, et al. Eur J Cell Biol, 2018 Sep. PMID 30097291
  5. Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Matthes H, et al. Mol Pharmacol, 1993 Mar. PMID 8450829

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cortisol up-regulated the expression and function of two serotonin (S) receptors, HTR2c and HTR5a.
    Title: Cortisol regulates immune and metabolic processes in murine adipocytes and macrophages through HTR2c and HTR5a serotonin receptors.
  2. This study demonistrated that loss of htr5A gene strongly upregulates 5-HT1A receptor-mediated currents in the prefrontal cortex.
    Title: The native serotonin 5-HT(5A) receptor: electrophysiological characterization in rodent cortex and 5-HT(1A)-mediated compensatory plasticity in the knock-out mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables Gi/o-coupled serotonin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine receptor 5A
Names
5-HT-5
5-HT-5A
5-HT5A
serotonin receptor 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420120.1 → NP_001407049.1  5-hydroxytryptamine receptor 5A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132397

  2. NM_008314.3 → NP_032340.2  5-hydroxytryptamine receptor 5A isoform 1

    See identical proteins and their annotated locations for NP_032340.2

    Status: VALIDATED

    Source sequence(s)
    AC132397
    Consensus CDS
    CCDS19141.1
    UniProtKB/Swiss-Prot
    P30966, Q3URB0
    Related
    ENSMUSP00000038884.6, ENSMUST00000036227.7
    Conserved Domains (1) summary
    pfam00001
    Location:57 → 338
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    28046836..28059403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30966.2 GenPept UniProtKB/Swiss-Prot:P30966

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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