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Elavl1 ELAV like RNA binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 15568, updated on 12-Nov-2024

Summary

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Official Symbol
Elavl1provided by MGI
Official Full Name
ELAV like RNA binding protein 1provided by MGI
Primary source
MGI:MGI:1100851
See related
Ensembl:ENSMUSG00000040028 AllianceGenome:MGI:1100851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HUR; Hua; 2410055N02Rik
Summary
Enables lncRNA binding activity and mRNA 3'-UTR AU-rich region binding activity. Involved in post-transcriptional regulation of gene expression; protein import into nucleus; and regulation of stem cell population maintenance. Acts upstream of or within positive regulation of translation. Located in several cellular components, including cytoplasmic stress granule; endoplasmic reticulum; and sarcoplasm. Part of ribonucleoprotein complex. Is active in cytoplasmic vesicle; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; early conceptus; and genitourinary system. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 16.0), whole brain E14.5 (RPKM 14.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Elavl1 in Genome Data Viewer
Location:
8 A1.1; 8 2.0 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4334781..4375104, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4284781..4325140, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cortexin 1 Neighboring gene translocase of inner mitochondrial membrane 44 Neighboring gene STARR-positive B cell enhancer ABC_E4988 Neighboring gene predicted gene, 50600 Neighboring gene C-C motif chemokine ligand 25 Neighboring gene predicted gene 7434

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RNA-binding protein HuR is a negative regulator in adipogenesis. Siang DTC, et al. Nat Commun, 2020 Jan 10. PMID 31924774, Free PMC Article
  2. HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4(+) T Cell Activation and Th17 Cell Differentiation. Yu S, et al. J Immunol Res, 2021. PMID 34395636, Free PMC Article
  3. The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. Subramanian P, et al. Hepatology, 2022 Apr. PMID 34519101
  4. RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway. Liu L, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165135, Free PMC Article
  5. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Chang SH, et al. Proc Natl Acad Sci U S A, 2014 Dec 23. PMID 25422430, Free PMC Article

See all (238) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HuR promotes triglyceride synthesis and intestinal fat absorption.
    Title: HuR promotes triglyceride synthesis and intestinal fat absorption.
  2. The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis.
    Title: The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis.
  3. Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R.
    Title: Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R.
  4. SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
    Title: SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
  5. HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
    Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
  6. HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation.
    Title: HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation.
  7. Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection.
    Title: Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection.
  8. HuR modulation counteracts lipopolysaccharide response in murine macrophages.
    Title: HuR modulation counteracts lipopolysaccharide response in murine macrophages.
  9. The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis.
    Title: The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis.
  10. Down-regulation of HuR inhibits pathological angiogenesis in oxygen-induced retinopathy.
    Title: Down-regulation of HuR inhibits pathological angiogenesis in oxygen-induced retinopathy.
Submit: New GeneRIF Correction See all GeneRIFs (140)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (10)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables lncRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in 3'-UTR-mediated mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA destabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of miRNA-mediated gene silencing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of superoxide anion generation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of translation ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic vesicle IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ELAV-like protein 1
Names
ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
HU-antigen A
elav-like generic protein
hu-antigen R
melG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010485.3 → NP_034615.2  ELAV-like protein 1

    See identical proteins and their annotated locations for NP_034615.2

    Status: VALIDATED

    Source sequence(s)
    AC155164, AK028769, AK080365, BB305633, BY775007
    Consensus CDS
    CCDS22084.1
    UniProtKB/Swiss-Prot
    P70372, Q60745, Q78QY3
    UniProtKB/TrEMBL
    Q3UFF9, Q8BM84, Q8BW03
    Related
    ENSMUSP00000096549.5, ENSMUST00000098950.6
    Conserved Domains (1) summary
    TIGR01661
    Location:19 → 326
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    4334781..4375104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508698.5 → XP_006508761.1  ELAV-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006508761.1

    UniProtKB/Swiss-Prot
    P70372, Q60745, Q78QY3
    UniProtKB/TrEMBL
    Q3UFF9, Q8BM84, Q8BW03
    Conserved Domains (1) summary
    TIGR01661
    Location:19 → 326
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. XM_030243302.2 → XP_030099162.1  ELAV-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P70372, Q60745, Q78QY3
    UniProtKB/TrEMBL
    Q3UFF9, Q8BM84, Q8BW03
    Conserved Domains (1) summary
    TIGR01661
    Location:19 → 326
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. XM_030243301.2 → XP_030099161.1  ELAV-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P70372, Q60745, Q78QY3
    UniProtKB/TrEMBL
    Q3UFF9, Q8BM84, Q8BW03
    Related
    ENSMUSP00000146866.2, ENSMUST00000209010.2
    Conserved Domains (1) summary
    TIGR01661
    Location:19 → 326
    ELAV_HUD_SF; ELAV/HuD family splicing factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70372.2 GenPept UniProtKB/Swiss-Prot:P70372

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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