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FAAH2 fatty acid amide hydrolase 2 [ Homo sapiens (human) ]

Gene ID: 158584, updated on 5-Mar-2024

Summary

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Official Symbol
FAAH2provided by HGNC
Official Full Name
fatty acid amide hydrolase 2provided by HGNC
Primary source
HGNC:HGNC:26440
See related
Ensembl:ENSG00000165591 MIM:300654; AllianceGenome:HGNC:26440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMDD
Summary
This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in liver (RPKM 2.5), skin (RPKM 1.5) and 24 other tissues See more
Orthologs
all
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Genomic context

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See FAAH2 in Genome Data Viewer
Location:
Xp11.21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (57121591..57489196)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (56420423..56788009)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57313110..57515629)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SPIN2 family pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:57143727-57144926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20870 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:57168413-57168642 Neighboring gene spindlin family member 2B Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:57203412-57203990 Neighboring gene spindlin family member 2A Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:57361506-57362334 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:57362335-57363162 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:57364391-57365161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:57392555-57393056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:57393057-57393556 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:57634195-57634694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:57673257-57673977 Neighboring gene NANOG hESC enhancer GRCh37_chrX:57677545-57678046 Neighboring gene uncharacterized LOC107985708 Neighboring gene zinc finger X-linked duplicated B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms. Sirrs S, et al. Orphanet J Rare Dis, 2015 Mar 28. PMID 25885783, Free PMC Article
  2. Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2. Kaczocha M, et al. J Biol Chem, 2010 Jan 22. PMID 19926788, Free PMC Article
  3. A second fatty acid amide hydrolase with variable distribution among placental mammals. Wei BQ, et al. J Biol Chem, 2006 Dec 1. PMID 17015445
  4. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Karbarz MJ, et al. Anesth Analg, 2009 Jan. PMID 19095868
  5. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. Johnson TP, et al. Proc Natl Acad Sci U S A, 2013 Aug 13. PMID 23898208, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A male patient with neuropsychiatric disorders attributed to a FAAH2 missense mutation is described.
    Title: Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms.
  2. results establish FAAH-2 as a bone fide N-acylethanolamine-catabolizing enzyme and suggest that inactivation is spatially separated in cells of higher mammals
    Title: Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2.
  3. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
    Title: Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
  4. FAAH2 is the second membrane-associated AS enzyme in humans that displays FAAH activity
    Title: A second fatty acid amide hydrolase with variable distribution among placental mammals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of fatty acid amide hydrolase 2 (FAAH2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid amide hydrolase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process TAS
Traceable Author Statement
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lipid droplet TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fatty-acid amide hydrolase 2
Names
amidase domain containing
amidase domain-containing protein
anandamide amidohydrolase 2
oleamide hydrolase 2
NP_001340769.1
NP_001340770.1
NP_777572.2
XP_005262042.1
XP_005262043.1
XP_005262044.1
XP_011529069.1
XP_016884779.1
XP_016884781.1
XP_016884782.1
XP_016884783.1
XP_047297816.1
XP_047297817.1
XP_047297818.1
XP_047297819.1
XP_047297820.1
XP_054182504.1
XP_054182505.1
XP_054182506.1
XP_054182507.1
XP_054182508.1
XP_054182509.1
XP_054182510.1
XP_054182511.1
XP_054182512.1
XP_054182513.1
XP_054182514.1
XP_054182515.1
XP_054182516.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013232.3 RefSeqGene

    Range
    170117..372604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001353840.1 → NP_001340769.1  fatty-acid amide hydrolase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL590394, AL606754, AL928898, BC073922, Z83745
    Conserved Domains (1) summary
    COG0154
    Location:48 → 486
    GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

  2. NM_001353841.1 → NP_001340770.1  fatty-acid amide hydrolase 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL590394, AL606754, AL928898, BC073922, Z83745
    Conserved Domains (1) summary
    COG0154
    Location:48 → 456
    GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

  3. NM_174912.4 → NP_777572.2  fatty-acid amide hydrolase 2 isoform 1

    See identical proteins and their annotated locations for NP_777572.2

    Status: REVIEWED

    Source sequence(s)
    AL590394, AL606754, AL928898, Z83745
    Consensus CDS
    CCDS14375.1
    UniProtKB/Swiss-Prot
    Q6GMR7, Q86VT2, Q96N98
    UniProtKB/TrEMBL
    B2C6G4
    Related
    ENSP00000364035.4, ENST00000374900.5
    Conserved Domains (1) summary
    COG0154
    Location:48 → 526
    GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_148557.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL590394, AL606754, AL928898, BC073922, Z83745

  2. NR_148564.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL590394, AL606754, AL928898, Z83745

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    57121591..57489196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530767.4 → XP_011529069.1  fatty-acid amide hydrolase 2 isoform X2

    See identical proteins and their annotated locations for XP_011529069.1

    Conserved Domains (1) summary
    COG0154
    Location:2 → 443
    GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

  2. XM_005261985.4 → XP_005262042.1  fatty-acid amide hydrolase 2 isoform X2

    See identical proteins and their annotated locations for XP_005262042.1

    Conserved Domains (1) summary
    COG0154
    Location:2 → 443
    GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

  3. XM_005261987.5 → XP_005262044.1  fatty-acid amide hydrolase 2 isoform X10

    Conserved Domains (1) summary
    COG0154
    Location:48 → 321
    GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

  4. XM_047441861.1 → XP_047297817.1  fatty-acid amide hydrolase 2 isoform X4

  5. XM_047441864.1 → XP_047297820.1  fatty-acid amide hydrolase 2 isoform X12

  6. XM_017029290.3 → XP_016884779.1  fatty-acid amide hydrolase 2 isoform X1

  7. XM_047441860.1 → XP_047297816.1  fatty-acid amide hydrolase 2 isoform X3

  8. XM_017029292.2 → XP_016884781.1  fatty-acid amide hydrolase 2 isoform X5

  9. XM_047441862.1 → XP_047297818.1  fatty-acid amide hydrolase 2 isoform X6

  10. XM_017029294.3 → XP_016884783.1  fatty-acid amide hydrolase 2 isoform X8

  11. XM_017029293.3 → XP_016884782.1  fatty-acid amide hydrolase 2 isoform X7

  12. XM_005261986.5 → XP_005262043.1  fatty-acid amide hydrolase 2 isoform X9

    Conserved Domains (1) summary
    COG0154
    Location:48 → 321
    GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

  13. XM_047441863.1 → XP_047297819.1  fatty-acid amide hydrolase 2 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    56420423..56788009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326530.1 → XP_054182505.1  fatty-acid amide hydrolase 2 isoform X2

  2. XM_054326531.1 → XP_054182506.1  fatty-acid amide hydrolase 2 isoform X2

  3. XM_054326539.1 → XP_054182514.1  fatty-acid amide hydrolase 2 isoform X10

  4. XM_054326533.1 → XP_054182508.1  fatty-acid amide hydrolase 2 isoform X4

  5. XM_054326541.1 → XP_054182516.1  fatty-acid amide hydrolase 2 isoform X12

  6. XM_054326529.1 → XP_054182504.1  fatty-acid amide hydrolase 2 isoform X1

  7. XM_054326532.1 → XP_054182507.1  fatty-acid amide hydrolase 2 isoform X3

  8. XM_054326534.1 → XP_054182509.1  fatty-acid amide hydrolase 2 isoform X5

  9. XM_054326535.1 → XP_054182510.1  fatty-acid amide hydrolase 2 isoform X6

  10. XM_054326537.1 → XP_054182512.1  fatty-acid amide hydrolase 2 isoform X8

  11. XM_054326536.1 → XP_054182511.1  fatty-acid amide hydrolase 2 isoform X7

  12. XM_054326538.1 → XP_054182513.1  fatty-acid amide hydrolase 2 isoform X9

  13. XM_054326540.1 → XP_054182515.1  fatty-acid amide hydrolase 2 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GMR7.1 GenPept UniProtKB/Swiss-Prot:Q6GMR7

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