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Id3 inhibitor of DNA binding 3 [ Mus musculus (house mouse) ]

Gene ID: 15903, updated on 2-Nov-2024

Summary

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Official Symbol
Id3provided by MGI
Official Full Name
inhibitor of DNA binding 3provided by MGI
Primary source
MGI:MGI:96398
See related
Ensembl:ENSMUSG00000007872 AllianceGenome:MGI:96398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Idb3; Hlh462; bHLHb25
Summary
Enables several functions, including bHLH transcription factor binding activity; leptomycin B binding activity; and transcription regulator inhibitor activity. Involved in several processes, including negative regulation of myoblast differentiation; notochord development; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to leptomycin B; negative regulation of macromolecule biosynthetic process; and negative regulation of osteoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and sensory organ. Used to study Sjogren's syndrome. Orthologous to human ID3 (inhibitor of DNA binding 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 274.3), stomach adult (RPKM 262.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Id3 in Genome Data Viewer
Location:
4 D3; 4 68.34 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135871133..135872703)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136143822..136145392)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2130 Neighboring gene ribosomal protein L11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135627400-135627509 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135643248-135643431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135644875-135644984 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135644986-135645252 Neighboring gene STARR-positive B cell enhancer ABC_E6236 Neighboring gene STARR-positive B cell enhancer ABC_E4687 Neighboring gene STARR-seq mESC enhancer starr_11745 Neighboring gene predicted gene, 42329 Neighboring gene STARR-positive B cell enhancer ABC_E10267 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135727983-135728166 Neighboring gene STARR-positive B cell enhancer ABC_E3530 Neighboring gene STARR-seq mESC enhancer starr_11747 Neighboring gene STARR-positive B cell enhancer ABC_E6237 Neighboring gene STARR-positive B cell enhancer ABC_E427 Neighboring gene E2F transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_11748 Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene STARR-seq mESC enhancer starr_11750

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells. Verykokakis M, et al. PLoS One, 2010 Feb 19. PMID 20174563, Free PMC Article
  2. Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation. Raab JR, et al. Development, 2020 Jan 3. PMID 31862843, Free PMC Article
  3. Null mutation of the transcription factor inhibitor of DNA binding 3 (id3) affects spermatozoal motility parameters and epididymal gene expression in mice. Carroll M, et al. Biol Reprod, 2011 Apr. PMID 21148110, Free PMC Article
  4. Developmental expression patterns and localization of DNA-binding protein inhibitor (Id3) in the mouse retina. Yeung SC, et al. Neuroreport, 2005 May 12. PMID 15858404
  5. Cutting Edge: Dynamic Expression of Id3 Defines the Stepwise Differentiation of Tissue-Resident Regulatory T Cells. Sullivan JM, et al. J Immunol, 2019 Jan 1. PMID 30518568, Free PMC Article

See all (292) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The nuclear factor ID3 endows macrophages with a potent anti-tumour activity.
    Title: The nuclear factor ID3 endows macrophages with a potent anti-tumour activity.
  2. Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke.
    Title: Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke.
  3. Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.
    Title: Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.
  4. Id3 expression identifies CD4(+) memory Th1 cells.
    Title: Id3 expression identifies CD4(+) memory Th1 cells.
  5. Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia.
    Title: Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia.
  6. ID1 and ID3 are Negative Regulators of TGFbeta2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.
    Title: ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.
  7. Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.
    Title: Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.
  8. Interleukin-21-mediated suppression of the Pax3-Id3 pathway exacerbates the development of Sjogren's syndrome via follicular helper T cells.
    Title: Interleukin-21-mediated suppression of the Pax3-Id3 pathway exacerbates the development of Sjögren's syndrome via follicular helper T cells.
  9. Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
    Title: Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
  10. Idgenes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.
    Title: Idgenes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.
Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables leptomycin B binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leptomycin B IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in central nervous system development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within epithelial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in metanephros development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in notochord development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in odontogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding protein inhibitor ID-3
Names
ID-like protein inhibitor HLH 462
inhibitor of differentiation 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429353.1 → NP_001416282.1  DNA-binding protein inhibitor ID-3

    Status: VALIDATED

    Source sequence(s)
    AL935264
    UniProtKB/Swiss-Prot
    P41133
    UniProtKB/TrEMBL
    Q545W1

  2. NM_008321.3 → NP_032347.1  DNA-binding protein inhibitor ID-3

    See identical proteins and their annotated locations for NP_032347.1

    Status: VALIDATED

    Source sequence(s)
    AL935264
    Consensus CDS
    CCDS18800.1
    UniProtKB/Swiss-Prot
    P41133
    UniProtKB/TrEMBL
    Q545W1
    Related
    ENSMUSP00000008016.3, ENSMUST00000008016.3
    Conserved Domains (1) summary
    cd19693
    Location:23 → 83
    bHLH_dnHLH_ID3; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135871133..135872703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41133.1 GenPept UniProtKB/Swiss-Prot:P41133

Gene LinkOut

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