Ier2 immediate early response 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ier2provided by MGI
Official Full Name: immediate early response 2provided by MGI
Primary source: MGI:MGI:104815
See related: Ensembl:ENSMUSG00000053560 AllianceGenome:MGI:104815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ch1; Pip92
Summary: Predicted to be involved in several processes, including neuron differentiation; positive regulation of transcription by RNA polymerase II; and response to fibroblast growth factor. Located in cytoplasm. Is expressed in several structures, including ear; forelimb bud; submandibular gland primordium; tooth; and vibrissa. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human IER2 (immediate early response 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.02 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85387960..85389481, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84661331..84662852, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IER2-induced senescence drives melanoma invasion through osteopontin.
Title: IER2-induced senescence drives melanoma invasion through osteopontin.
Relief of contact inhibition was associated with translocation of the Ier2 protein from the cytoplasm to the nucleus in both 3T3 fibroblasts and 1AS tumor cells
Title: The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients.
shows a rapid and long-lasting induction after cerebral ischemia; induces cell death in primary neurons and displays several hallmarks of pro-apoptotic activity upon overexpression
Title: Restriction-mediated differential display (RMDD) identifies pip92 as a pro-apoptotic gene product induced during focal cerebral ischemia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

M59821 (e-PCR)
- UniSTS:159782

RH136174 (e-PCR)
- UniSTS:210169

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to fibroblast growth factor	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: immediate early response gene 2 protein

Names: CHX1; T-lymphocyte-activated protein; cycloheximide-induced gene protein; growth factor-inducible immediate early protein; proline-rich-induced protein 92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.