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Ifi203 interferon activated gene 203 [ Mus musculus (house mouse) ]

Gene ID: 15950, updated on 2-Nov-2024

Summary

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Official Symbol
Ifi203provided by MGI
Official Full Name
interferon activated gene 203provided by MGI
Primary source
MGI:MGI:96428
See related
Ensembl:ENSMUSG00000039997 AllianceGenome:MGI:96428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mndal; Ifi203a; Ifi203b
Summary
Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Acts upstream of or within cellular response to interferon-beta. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 5.0), mammary gland adult (RPKM 4.3) and 18 other tissues See more
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Genomic context

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See Ifi203 in Genome Data Viewer
Location:
1 H3; 1 80.76 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173747966..173770432, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173920400..173942866, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 21031 Neighboring gene interferon activated gene 211 Neighboring gene STARR-positive B cell enhancer ABC_E11108 Neighboring gene STARR-positive B cell enhancer ABC_E3335 Neighboring gene STARR-positive B cell enhancer ABC_E11109 Neighboring gene interferon activated gene 202B Neighboring gene interferon activated gene 204 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interferons as gene activators: close linkage of two interferon-activatable murine genes. Engel DA, et al. Virology, 1988 Sep. PMID 2457983
  2. Multiple splicing results in at least two p203 proteins that are expressed in the liver and down-regulated during liver regeneration. Zhang Y, et al. Front Biosci, 2008 Jan 1. PMID 17981725
  3. Molecular cloning and expression of an interferon-inducible protein encoded by gene 203 from the gene 200 cluster. Gribaudo G, et al. Eur J Biochem, 1997 Oct 1. PMID 9363777
  4. In vitro and in vivo expression analysis of the interferon-inducible 203 gene. Gribaudo G, et al. J Interferon Cytokine Res, 1999 Feb. PMID 10090398
  5. Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Norheim F, et al. Mol Syst Biol, 2021 Jan. PMID 33417276, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
    Title: Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
  2. analysis of p203 proteins that are expressed in the liver and down-regulated during liver regeneration
    Title: Multiple splicing results in at least two p203 proteins that are expressed in the liver and down-regulated during liver regeneration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of AIM2 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon-activable protein 203
Names
interferon-inducible protein p203

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302649.1 → NP_001289578.1  interferon-activable protein 203 isoform 1

    See identical proteins and their annotated locations for NP_001289578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC170584, AK040214, AK137616, AK144663, BE691222
    Consensus CDS
    CCDS78754.1
    UniProtKB/TrEMBL
    A0A1Z3MHZ5, E9QAN9
    Related
    ENSMUSP00000122424.2, ENSMUST00000129829.8
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:665 → 831
    HIN; HIN-200/IF120x domain

  2. NM_001302650.1 → NP_001289579.1  interferon-activable protein 203 isoform 2

    See identical proteins and their annotated locations for NP_001289579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK144663, BE691222
    Consensus CDS
    CCDS48453.1
    UniProtKB/Swiss-Prot
    O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8
    UniProtKB/TrEMBL
    A0A0R4J0H6
    Related
    ENSMUSP00000114221.2, ENSMUST00000156895.8
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:251 → 417
    HIN; HIN-200/IF120x domain

  3. NM_001302651.1 → NP_001289580.1  interferon-activable protein 203 isoform 3

    See identical proteins and their annotated locations for NP_001289580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK040214, AK144663, BE691222
    Consensus CDS
    CCDS35793.1
    UniProtKB/Swiss-Prot
    O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8
    UniProtKB/TrEMBL
    E9PUG6
    Related
    ENSMUSP00000121480.2, ENSMUST00000123708.8
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:203 → 369
    HIN; HIN-200/IF120x domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173747966..173770432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250226.1 → XP_030106086.1  interferon-activable protein 203 isoform X5

    Conserved Domains (1) summary
    pfam02760
    Location:377 → 543
    HIN; HIN-200/IF120x domain

  2. XM_030250260.1 → XP_030106120.1  interferon-activable protein 203 isoform X7

    UniProtKB/Swiss-Prot
    O35368, Q3T9I1, Q3TEA2, Q3TP57, Q3UMV2, Q8BYE5, Q91VV8
    UniProtKB/TrEMBL
    E9PUG6
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:203 → 369
    HIN; HIN-200/IF120x domain

  3. XM_011238761.4 → XP_011237063.1  interferon-activable protein 203 isoform X1

    See identical proteins and their annotated locations for XP_011237063.1

    UniProtKB/TrEMBL
    A0A1Z3MHZ5
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:677 → 843
    HIN; HIN-200/IF120x domain

  4. XM_011238760.3 → XP_011237062.1  interferon-activable protein 203 isoform X1

    See identical proteins and their annotated locations for XP_011237062.1

    UniProtKB/TrEMBL
    A0A1Z3MHZ5
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:677 → 843
    HIN; HIN-200/IF120x domain

  5. XM_036162001.1 → XP_036017894.1  interferon-activable protein 203 isoform X6

    Conserved Domains (1) summary
    pfam02760
    Location:365 → 531
    HIN; HIN-200/IF120x domain

  6. XM_006496669.4 → XP_006496732.1  interferon-activable protein 203 isoform X3

    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:629 → 795
    HIN; HIN-200/IF120x domain

  7. XM_011238762.3 → XP_011237064.1  interferon-activable protein 203 isoform X2

    See identical proteins and their annotated locations for XP_011237064.1

    UniProtKB/TrEMBL
    A0A1Z3MHZ5, E9QAN9
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:665 → 831
    HIN; HIN-200/IF120x domain

  8. XM_006496671.5 → XP_006496734.1  interferon-activable protein 203 isoform X4

    Conserved Domains (1) summary
    pfam02760
    Location:485 → 651
    HIN; HIN-200/IF120x domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001045481.1: Suppressed sequence

    Description
    NM_001045481.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  2. NM_008328.2: Suppressed sequence

    Description
    NM_008328.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35368.1 GenPept UniProtKB/Swiss-Prot:O35368

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