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Il11ra2 interleukin 11 receptor subunit alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 16158, updated on 2-Nov-2024

Summary

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Official Symbol
Il11ra2provided by MGI
Official Full Name
interleukin 11 receptor subunit alpha 2provided by MGI
Primary source
MGI:MGI:109123
See related
Ensembl:ENSMUSG00000078735 AllianceGenome:MGI:109123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etl2; Etl-2; Il11ra-ps1
Summary
Predicted to enable interleukin-11 binding activity and interleukin-11 receptor activity. Predicted to be involved in several processes, including embryo implantation; interleukin-11-mediated signaling pathway; and positive regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; integumental system; and nervous system. Orthologous to human IL11RA (interleukin 11 receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 19.5), adrenal adult (RPKM 18.8) and 28 other tissues See more
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Genomic context

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See Il11ra2 in Genome Data Viewer
Location:
4 A5; 4 22.73 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42656001..42665744, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42655275..42665763, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 19, pseudogene 2 Neighboring gene C-C motif chemokine ligand 21E Neighboring gene C-C motif chemokine ligand 19, pseudogene 4 Neighboring gene RIKEN cDNA 4930578G10 gene Neighboring gene C-C motif chemokine ligand 27b Neighboring gene predicted gene, 53182 Neighboring gene family with sequence similarity 205 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus. Robb L, et al. J Biol Chem, 1996 Jun 7. PMID 8662802
  2. Two differentially expressed interleukin-11 receptor genes in the mouse genome. Bilinski P, et al. Biochem J, 1996 Dec 1. PMID 8973540, Free PMC Article
  3. Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression. Robb L, et al. Genomics, 1997 Mar 15. PMID 9073505
  4. Enhancer trap integrations in mouse embryonic stem cells give rise to staining patterns in chimaeric embryos with a high frequency and detect endogenous genes. Korn R, et al. Mech Dev, 1992 Nov. PMID 1283314
  5. IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice. Chen W, et al. J Immunol, 2009 Dec 15. PMID 20007572, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-11 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-11 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-11 receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in developmental process ISO
Inferred from Sequence Orthology
more info
  
involved_in embryo implantation ISO
Inferred from Sequence Orthology
more info
  
involved_in head development ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-11-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-11 receptor subunit alpha-2
Names
IL-11 receptor subunit alpha-2
IL-11 receptor subunit beta
IL-11R subunit alpha-2
IL-11R subunit beta
IL-11R-alpha-2
IL-11R-beta
IL-11RA2
IL-11RB
interleukin 11 receptor, alpha chain 2
interleukin-11 receptor subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403831.1 → NP_001390760.1  interleukin-11 receptor subunit alpha-2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    BX548253
    UniProtKB/Swiss-Prot
    A2RTL4, B1AXR8, O09074, P70225, Q78DW8
    Related
    ENSMUSP00000103641.4, ENSMUST00000108006.4

  2. NM_010550.4 → NP_034680.3  interleukin-11 receptor subunit alpha-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034680.3

    Status: VALIDATED

    Source sequence(s)
    BX548253
    Consensus CDS
    CCDS38735.1
    UniProtKB/Swiss-Prot
    A2RTL4, B1AXR8, O09074, P70225, Q78DW8
    UniProtKB/TrEMBL
    Q3UIV4
    Related
    ENSMUSP00000158819.2, ENSMUST00000238770.2
    Conserved Domains (4) summary
    smart00410
    Location:33 → 95
    IG_like; Immunoglobulin like
    cd00063
    Location:218 → 310
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:35 → 98
    Ig; Immunoglobulin domain
    cl21522
    Location:112 → 202
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    42656001..42665744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163735.1 → XP_036019628.1  interleukin-11 receptor subunit alpha-2 isoform X2

    UniProtKB/TrEMBL
    Q3UIV4
    Conserved Domains (2) summary
    smart00409
    Location:37 → 99
    IG; Immunoglobulin
    cd00063
    Location:222 → 314
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70225.4 GenPept UniProtKB/Swiss-Prot:P70225

Gene LinkOut

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Molecular Biology Databases
Research Materials