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Gimap1 GTPase, IMAP family member 1 [ Mus musculus (house mouse) ]

Gene ID: 16205, updated on 2-Nov-2024

Summary

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Official Symbol
Gimap1provided by MGI
Official Full Name
GTPase, IMAP family member 1provided by MGI
Primary source
MGI:MGI:109368
See related
Ensembl:ENSMUSG00000090019 AllianceGenome:MGI:109368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
imap; IAP38; Imap38
Summary
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. Sequence analysis identified two alternatively spliced variants that encode the same protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen adult (RPKM 37.2), thymus adult (RPKM 24.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Gimap1 in Genome Data Viewer
Location:
6 B2.3; 6 23.69 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48715981..48720729)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48739047..48743795)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 6 Neighboring gene STARR-positive B cell enhancer ABC_E8100 Neighboring gene STARR-positive B cell enhancer ABC_E6427 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48668564-48668753 Neighboring gene GTPase, IMAP family member 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48677906-48678089 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48682931-48683193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48688984-48689167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48689235-48689400 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48696005-48696158 Neighboring gene STARR-positive B cell enhancer ABC_E10378 Neighboring gene STARR-positive B cell enhancer ABC_E1320 Neighboring gene GTPase, IMAP family member 5 Neighboring gene STARR-seq mESC enhancer starr_15794 Neighboring gene STARR-positive B cell enhancer ABC_E8101 Neighboring gene GTPase, IMAP family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel gene expressed in spleen cells mediating acquired testosterone-resistant immunity to Plasmodium chabaudi malaria. Krücken J, et al. Biochem Biophys Res Commun, 1997 Jan 3. PMID 9020038
  2. Spleen-specific expression of the malaria-inducible intronless mouse gene imap38. Krücken J, et al. J Biol Chem, 1999 Aug 20. PMID 10446218
  3. Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria. Saunders A, et al. Malar J, 2009 Apr 2. PMID 19338674, Free PMC Article
  4. Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice. Datta P, et al. Eur J Immunol, 2017 Jan. PMID 27792288, Free PMC Article
  5. Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes. Saunders A, et al. Blood, 2010 Apr 22. PMID 20194894

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study shows that GIMAP1 is critical for maintaining the peripheral T-cell pool in mice and offers a potent target for the treatment of T-cell-mediated diseases.
    Title: Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice.
  2. The data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state.
    Title: GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.
  3. These findings show a vital requirement for GIMAP1 in mature lymphocyte development/survival
    Title: Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes.
  4. The model of up-regulation of GIMAP1 in response to infection/immunization with P. chabaudi is not a robustly reproducible experimental system.
    Title: Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTPase IMAP family member 1
Names
immune associated nucleotide family member
immune-associated protein 38
immunity-associated protein 1
immunity-associated protein, 38 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008376.3 → NP_032402.2  GTPase IMAP family member 1

    See identical proteins and their annotated locations for NP_032402.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer and predominant variant. Both variants encode the same protein.
    Source sequence(s)
    CAAA01157263
    Consensus CDS
    CCDS20113.1
    UniProtKB/Swiss-Prot
    P70224
    UniProtKB/TrEMBL
    Q3TFI6
    Related
    ENSMUSP00000062108.5, ENSMUST00000054368.7
    Conserved Domains (2) summary
    cd01852
    Location:27 → 229
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)
    cl00459
    Location:217 → 294
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  2. NM_175860.2 → NP_787056.1  GTPase IMAP family member 1

    See identical proteins and their annotated locations for NP_787056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, that results in a shorter transcript. Both variants encode the same protein.
    Source sequence(s)
    CAAA01157263
    Consensus CDS
    CCDS20113.1
    UniProtKB/Swiss-Prot
    P70224
    UniProtKB/TrEMBL
    Q3TFI6
    Related
    ENSMUSP00000145479.2, ENSMUST00000204168.2
    Conserved Domains (2) summary
    cd01852
    Location:27 → 229
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)
    cl00459
    Location:217 → 294
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48715981..48720729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70224.3 GenPept UniProtKB/Swiss-Prot:P70224

Gene LinkOut

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