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MARCHF10 membrane associated ring-CH-type finger 10 [ Homo sapiens (human) ]

Gene ID: 162333, updated on 2-Nov-2024

Summary

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Official Symbol
MARCHF10provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 10provided by HGNC
Primary source
HGNC:HGNC:26655
See related
Ensembl:ENSG00000173838 MIM:613337; AllianceGenome:HGNC:26655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF190; MARCH-X; MARCH10
Summary
MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Expression
Restricted expression toward testis (RPKM 20.7) See more
Orthologs
mouse all
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Genomic context

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See MARCHF10 in Genome Data Viewer
Location:
17q23.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62701314..62808314, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63571227..63678377, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60778675..60885675, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60707912-60708768 Neighboring gene mannose receptor C-type 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729214-60729925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729926-60730636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60731349-60732059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60743431-60744021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60746820-60747579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60747580-60748338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60748658-60749158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60749159-60749659 Neighboring gene Sharpr-MPRA regulatory region 5505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60757143-60757871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60769301-60769962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60769963-60770624 Neighboring gene RNA, U6 small nuclear 446, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8811 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60781806-60782032 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:60782895-60783686 Neighboring gene uncharacterized LOC105371855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12543 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60817295-60817950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60827154-60827763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60827764-60828372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:60839055-60839580 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60839581-60840107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8813 Neighboring gene MARCHF10 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60902506-60903242 Neighboring gene PRELI domain containing 3B pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. Morokuma Y, et al. J Biol Chem, 2007 Aug 24. PMID 17604280
  2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. Aouizerat BE, et al. BMC Cardiovasc Disord, 2011 Jun 10. PMID 21658281, Free PMC Article
  3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2009 Oct. PMID 19724895
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2010 Apr. PMID 20198315

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35757

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase MARCHF10
Names
RING-type E3 ubiquitin transferase MARCH10
RING-type E3 ubiquitin transferase MARCHF10
membrane associated ring finger 10
membrane-associated RING finger protein 10
membrane-associated RING-CH protein X
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
probable E3 ubiquitin-protein ligase MARCH10
ring finger protein 190
testis secretory sperm-binding protein Li 228n
NP_001094345.1
NP_001275708.1
NP_001275709.1
NP_689811.2
XP_005257152.2
XP_005257153.2
XP_005257154.2
XP_005257155.2
XP_005257157.2
XP_005257159.2
XP_005257160.1
XP_005257163.2
XP_011522737.1
XP_011522738.1
XP_011522739.1
XP_054171230.1
XP_054171231.1
XP_054171232.1
XP_054171233.1
XP_054171234.1
XP_054171235.1
XP_054171236.1
XP_054171237.1
XP_054171238.1
XP_054171239.1
XP_054171240.1
XP_054171241.1
XP_054171242.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100875.3 → NP_001094345.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 1

    See identical proteins and their annotated locations for NP_001094345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
    Source sequence(s)
    AK093076, AK122947, AW473122, BC035021
    Consensus CDS
    CCDS11635.1
    UniProtKB/Swiss-Prot
    D3DU09, Q8IYS7, Q8N7Z7, Q8NA82
    UniProtKB/TrEMBL
    A0A140VKA1, B3KVK0
    Related
    ENSP00000416177.2, ENST00000456609.6
    Conserved Domains (1) summary
    smart00744
    Location:659 → 715
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  2. NM_001288779.2 → NP_001275708.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 2

    See identical proteins and their annotated locations for NP_001275708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (2).
    Source sequence(s)
    AW138484, AW473122, BC035021, BX648705
    Consensus CDS
    CCDS74123.1
    UniProtKB/TrEMBL
    B3KVK0, J3KTN9
    Related
    ENSP00000463080.1, ENST00000583600.5
    Conserved Domains (1) summary
    smart00744
    Location:697 → 753
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  3. NM_001288780.2 → NP_001275709.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 3

    See identical proteins and their annotated locations for NP_001275709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and contains multiple coding region differences, compared to variant 3. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AI223162, AI262871, AK122947, AW263642, BC035021, BX105355, HY010920
    Consensus CDS
    CCDS74122.1
    UniProtKB/TrEMBL
    B3KVK0, G3V1Q5
    Related
    ENSP00000443746.2, ENST00000544856.6
    Conserved Domains (1) summary
    smart00744
    Location:658 → 714
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  4. NM_152598.4 → NP_689811.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform 1

    See identical proteins and their annotated locations for NP_689811.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
    Source sequence(s)
    AK093076, AK122947, AW473122, BC035021
    Consensus CDS
    CCDS11635.1
    UniProtKB/Swiss-Prot
    D3DU09, Q8IYS7, Q8N7Z7, Q8NA82
    UniProtKB/TrEMBL
    A0A140VKA1, B3KVK0
    Related
    ENSP00000311496.5, ENST00000311269.10
    Conserved Domains (1) summary
    smart00744
    Location:659 → 715
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    62701314..62808314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257102.4 → XP_005257159.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:658 → 714
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  2. XM_005257100.4 → XP_005257157.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

    See identical proteins and their annotated locations for XP_005257157.2

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:659 → 715
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  3. XM_005257098.4 → XP_005257155.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X2

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:696 → 752
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  4. XM_011524435.3 → XP_011522737.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X3

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:696 → 752
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  5. XM_005257095.4 → XP_005257152.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

    See identical proteins and their annotated locations for XP_005257152.2

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:697 → 753
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  6. XM_011524436.2 → XP_011522738.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

    See identical proteins and their annotated locations for XP_011522738.1

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:659 → 715
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  7. XM_005257096.3 → XP_005257153.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

    See identical proteins and their annotated locations for XP_005257153.2

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:697 → 753
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  8. XM_011524437.3 → XP_011522739.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X6

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:658 → 714
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  9. XM_005257097.3 → XP_005257154.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

    See identical proteins and their annotated locations for XP_005257154.2

    UniProtKB/TrEMBL
    B3KVK0
    Conserved Domains (1) summary
    smart00744
    Location:697 → 753
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  10. XM_005257106.4 → XP_005257163.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X8

    UniProtKB/TrEMBL
    J3QRH7
    Related
    ENSP00000464220.1, ENST00000580520.5
    Conserved Domains (1) summary
    smart00744
    Location:586 → 642
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  11. XM_005257103.3 → XP_005257160.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X7

    See identical proteins and their annotated locations for XP_005257160.1

    UniProtKB/TrEMBL
    B3KVK0, G3V1Q5
    Conserved Domains (1) summary
    smart00744
    Location:658 → 714
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RNA

  1. XR_934406.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    63571227..63678377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315262.1 → XP_054171237.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

  2. XM_054315260.1 → XP_054171235.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

  3. XM_054315258.1 → XP_054171233.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X2

  4. XM_054315259.1 → XP_054171234.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X3

  5. XM_054315255.1 → XP_054171230.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

  6. XM_054315261.1 → XP_054171236.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

  7. XM_054315256.1 → XP_054171231.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

  8. XM_054315263.1 → XP_054171238.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X6

  9. XM_054315257.1 → XP_054171232.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

  10. XM_054315265.1 → XP_054171240.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X8

  11. XM_054315264.1 → XP_054171239.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X7

  12. XM_054315266.1 → XP_054171241.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X9

  13. XM_054315267.1 → XP_054171242.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X9

RNA

  1. XR_008484791.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NA82.3 GenPept UniProtKB/Swiss-Prot:Q8NA82

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