U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DCC DCC netrin 1 receptor [ Homo sapiens (human) ]

Gene ID: 1630, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
DCCprovided by HGNC
Official Full Name
DCC netrin 1 receptorprovided by HGNC
Primary source
HGNC:HGNC:2701
See related
Ensembl:ENSG00000187323 MIM:120470; AllianceGenome:HGNC:2701
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1
Summary
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Expression
Biased expression in testis (RPKM 2.4), brain (RPKM 1.4) and 2 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DCC in Genome Data Viewer
Location:
18q21.2
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (52340197..53535899)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (52543078..53739020)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (49866567..51062269)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr18:49472122-49472636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13337 Neighboring gene NANOG hESC enhancer GRCh37_chr18:49514627-49515128 Neighboring gene ribosomal protein S8 pseudogene 3 Neighboring gene VISTA enhancer hs1384 Neighboring gene uncharacterized LOC105372121 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:49595452-49596115 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:49754501-49755047 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:49850127-49850638 Neighboring gene vomeronasal 1 receptor 76 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:50162292-50163491 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47967 Neighboring gene NANOG hESC enhancer GRCh37_chr18:50208549-50209050 Neighboring gene NANOG hESC enhancer GRCh37_chr18:50334126-50334627 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:50582336-50582939 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:50780507-50781098 Neighboring gene microRNA 4528 Neighboring gene uncharacterized LOC124904305 Neighboring gene uncharacterized LOC124904304 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:51037281-51038480 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:51093005-51093861 Neighboring gene long intergenic non-protein coding RNA 1919 Neighboring gene long intergenic non-protein coding RNA 1917 Neighboring gene ribosomal protein L29 pseudogene 32

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel DCC mutation and genetic heterogeneity in congenital mirror movements. Depienne C, et al. Neurology, 2011 Jan 18. PMID 21242494
  2. DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin. Martín M, et al. Eur J Cell Biol, 2006 Aug. PMID 16762451
  3. Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with beta-catenin levels and outcome in patients with epithelial ovarian cancer. Bamias A, et al. Ann Oncol, 2006 Dec. PMID 16971669
  4. Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. Carvalho AL, et al. Cancer Res, 2006 Oct 1. PMID 17018594
  5. Androgen-regulated genes differentially modulated by the androgen receptor coactivator L-dopa decarboxylase in human prostate cancer cells. Margiotti K, et al. Mol Cancer, 2007 Jun 6. PMID 17553164, Free PMC Article

See all (155) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the Pathogenesis of Placenta Accreta Spectrum: A Case-control Study.
    Title: Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the Pathogenesis of Placenta Accreta Spectrum: A Case-control Study.
  2. NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer.
    Title: NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer.
  3. Identification of specific codon 201 mutation of the DCC Gene in the colonoscopic specimen of colorectal cancer.
    Title: Identification of specific codon 201 mutation of the DCC Gene in the colonoscopic specimen of colorectal cancer.
  4. An imbalance of netrin-1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease.
    Title: An imbalance of netrin-1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease.
  5. Mirror movements and callosal dysgenesis in a family with a DCC mutation: Neuropsychological and neuroimaging outcomes.
    Title: Mirror movements and callosal dysgenesis in a family with a DCC mutation: Neuropsychological and neuroimaging outcomes.
  6. Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children.
    Title: Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children.
  7. Genetic Susceptibility of DCC Gene in Gallbladder Cancer in Kashmir and Meta-Analysis.
    Title: Genetic Susceptibility of DCC Gene in Gallbladder Cancer in Kashmir and Meta-Analysis.
  8. Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study.
    Title: Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study.
  9. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood.
    Title: DCC gene network in the prefrontal cortex is associated with total brain volume in childhood.
  10. Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features.
    Title: Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features.
Submit: New GeneRIF Correction See all GeneRIFs (89)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Colorectal cancer
MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
Compare labs
Gaze palsy, familial horizontal, with progressive scoliosis, 2
MedGen: C4479640 OMIM: 617542 GeneReviews: Not available
Compare labs
Malignant tumor of esophagus
MedGen: C0546837 OMIM: 133239 GeneReviews: Not available
Compare labs
Mirror movements 1
MedGen: C1834870 OMIM: 157600 GeneReviews: Congenital Mirror Movements
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population.
EBI GWAS Catalog
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
EBI GWAS Catalog
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
EBI GWAS Catalog
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
EBI GWAS Catalog
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axon guidance IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dorsal/ventral axon guidance IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of collateral sprouting TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of dendrite development TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of neuron projection development TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in spinal cord ventral commissure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
netrin receptor DCC
Names
colorectal cancer suppressor
deleted in colorectal carcinoma
immunoglobulin superfamily DCC subclass member 1
putative colorectal tumor suppressor
tumor suppressor protein DCC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013341.2 RefSeqGene

    Range
    5026..1200728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1107

mRNA and Protein(s)

  1. NM_005215.4 → NP_005206.2  netrin receptor DCC

    See identical proteins and their annotated locations for NP_005206.2

    Status: REVIEWED

    Source sequence(s)
    AC011155, AC103949, BC036524, X76132
    Consensus CDS
    CCDS11952.1
    UniProtKB/Swiss-Prot
    P43146
    Related
    ENSP00000389140.2, ENST00000442544.7
    Conserved Domains (8) summary
    cd05722
    Location:41 → 136
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:153 → 219
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:726 → 805
    FN3; Fibronectin type 3 domain
    smart00410
    Location:147 → 224
    IG_like; Immunoglobulin like
    cd00063
    Location:528 → 617
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:331 → 417
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:1148 → 1445
    Neogenin_C; Neogenin C-terminus
    cl11960
    Location:347 → 417
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    52340197..53535899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025568.2 → XP_016881057.1  netrin receptor DCC isoform X1

  2. XM_017025569.2 → XP_016881058.1  netrin receptor DCC isoform X2

  3. XM_047437311.1 → XP_047293267.1  netrin receptor DCC isoform X3

  4. XM_011525844.3 → XP_011524146.1  netrin receptor DCC isoform X4

    UniProtKB/TrEMBL
    J3QS93
    Related
    ENSP00000464582.1, ENST00000581580.5
    Conserved Domains (5) summary
    smart00060
    Location:381 → 460
    FN3; Fibronectin type 3 domain
    cd00063
    Location:183 → 272
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:2 → 72
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:803 → 1100
    Neogenin_C; Neogenin C-terminus
    cl11960
    Location:2 → 72
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    52543078..53739020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318227.1 → XP_054174202.1  netrin receptor DCC isoform X1

  2. XM_054318228.1 → XP_054174203.1  netrin receptor DCC isoform X2

  3. XM_054318229.1 → XP_054174204.1  netrin receptor DCC isoform X3

  4. XM_054318230.1 → XP_054174205.1  netrin receptor DCC isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43146.2 GenPept UniProtKB/Swiss-Prot:P43146

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Medical
Molecular Biology Databases
Research Materials
Tools
Miscellaneous