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ZNF780B zinc finger protein 780B [ Homo sapiens (human) ]

Gene ID: 163131, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF780Bprovided by HGNC
Official Full Name
zinc finger protein 780Bprovided by HGNC
Primary source
HGNC:HGNC:33109
See related
Ensembl:ENSG00000128000 AllianceGenome:HGNC:33109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF779
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 2.6), ovary (RPKM 2.0) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZNF780B in Genome Data Viewer
Location:
19q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40028260..40056231, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42848466..42876439, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40534167..40562138, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:40502617-40503116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10615 Neighboring gene zinc finger protein 546 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:40520495-40521694 Neighboring gene PAT1 homolog 1, processing body mRNA decay factor pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:40541448-40542647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14637 Neighboring gene zinc finger protein 780A Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:40596583-40597124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14638 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:40613086-40613650 Neighboring gene uncharacterized LOC124904803

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  2. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 780B
Names
zinc finger protein 779

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005851.3 → NP_001005851.1  zinc finger protein 780B

    See identical proteins and their annotated locations for NP_001005851.1

    Status: VALIDATED

    Source sequence(s)
    AC005614, AC007842, BC136960, CB053507
    Consensus CDS
    CCDS46077.1
    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6
    Related
    ENSP00000391641.1, ENST00000434248.6
    Conserved Domains (4) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:191 → 632
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:615 → 635
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:740 → 764
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40028260..40056231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258591.6 → XP_005258648.1  zinc finger protein 780B isoform X1

    See identical proteins and their annotated locations for XP_005258648.1

    Conserved Domains (5) summary
    smart00349
    Location:6 → 67
    KRAB; krueppel associated box
    COG5048
    Location:192 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336 → 356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:377 → 401
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017026426.2 → XP_016881915.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6
    Conserved Domains (4) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:191 → 632
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:615 → 635
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:740 → 764
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047438337.1 → XP_047294293.1  zinc finger protein 780B isoform X1

  4. XM_017026425.3 → XP_016881914.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6
    Conserved Domains (4) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:191 → 632
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:615 → 635
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:740 → 764
    zf-H2C2_2; Zinc-finger double domain

  5. XM_006723072.5 → XP_006723135.1  zinc finger protein 780B isoform X1

    See identical proteins and their annotated locations for XP_006723135.1

    Conserved Domains (5) summary
    smart00349
    Location:6 → 67
    KRAB; krueppel associated box
    COG5048
    Location:192 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336 → 356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:377 → 401
    zf-H2C2_2; Zinc-finger double domain

  6. XM_017026427.2 → XP_016881916.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6
    Conserved Domains (4) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:191 → 632
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:615 → 635
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:740 → 764
    zf-H2C2_2; Zinc-finger double domain

  7. XM_005258595.4 → XP_005258652.1  zinc finger protein 780B isoform X1

    See identical proteins and their annotated locations for XP_005258652.1

    Conserved Domains (5) summary
    smart00349
    Location:6 → 67
    KRAB; krueppel associated box
    COG5048
    Location:192 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336 → 356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:377 → 401
    zf-H2C2_2; Zinc-finger double domain

  8. XM_047438340.1 → XP_047294296.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  9. XM_005258592.4 → XP_005258649.1  zinc finger protein 780B isoform X1

    See identical proteins and their annotated locations for XP_005258649.1

    Conserved Domains (5) summary
    smart00349
    Location:6 → 67
    KRAB; krueppel associated box
    COG5048
    Location:192 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336 → 356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:377 → 401
    zf-H2C2_2; Zinc-finger double domain

  10. XM_005258593.3 → XP_005258650.1  zinc finger protein 780B isoform X2

    See identical proteins and their annotated locations for XP_005258650.1

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6
    Conserved Domains (4) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:191 → 632
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:615 → 635
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:740 → 764
    zf-H2C2_2; Zinc-finger double domain

  11. XM_005258590.5 → XP_005258647.1  zinc finger protein 780B isoform X1

    See identical proteins and their annotated locations for XP_005258647.1

    Conserved Domains (5) summary
    smart00349
    Location:6 → 67
    KRAB; krueppel associated box
    COG5048
    Location:192 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336 → 356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:377 → 401
    zf-H2C2_2; Zinc-finger double domain

  12. XM_047438342.1 → XP_047294298.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  13. XM_011526593.3 → XP_011524895.1  zinc finger protein 780B isoform X1

    See identical proteins and their annotated locations for XP_011524895.1

    Conserved Domains (5) summary
    smart00349
    Location:6 → 67
    KRAB; krueppel associated box
    COG5048
    Location:192 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336 → 356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:377 → 401
    zf-H2C2_2; Zinc-finger double domain

  14. XM_047438341.1 → XP_047294297.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  15. XM_047438339.1 → XP_047294295.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  16. XM_047438338.1 → XP_047294294.1  zinc finger protein 780B isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646206.1 Reference GRCh38.p14 PATCHES

    Range
    303403..331374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331620.1 → XP_054187595.1  zinc finger protein 780B isoform X1

  2. XM_054331628.1 → XP_054187603.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  3. XM_054331621.1 → XP_054187596.1  zinc finger protein 780B isoform X1

  4. XM_054331627.1 → XP_054187602.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  5. XM_054331619.1 → XP_054187594.1  zinc finger protein 780B isoform X1

  6. XM_054331629.1 → XP_054187604.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  7. XM_054331622.1 → XP_054187597.1  zinc finger protein 780B isoform X1

  8. XM_054331630.1 → XP_054187605.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  9. XM_054331626.1 → XP_054187601.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  10. XM_054331623.1 → XP_054187598.1  zinc finger protein 780B isoform X1

  11. XM_054331631.1 → XP_054187606.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  12. XM_054331632.1 → XP_054187607.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  13. XM_054331633.1 → XP_054187608.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  14. XM_054331625.1 → XP_054187600.1  zinc finger protein 780B isoform X1

  15. XM_054331624.1 → XP_054187599.1  zinc finger protein 780B isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42848466..42876439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320067.1 → XP_054176042.1  zinc finger protein 780B isoform X1

  2. XM_054320075.1 → XP_054176050.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  3. XM_054320068.1 → XP_054176043.1  zinc finger protein 780B isoform X1

  4. XM_054320074.1 → XP_054176049.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  5. XM_054320066.1 → XP_054176041.1  zinc finger protein 780B isoform X1

  6. XM_054320076.1 → XP_054176051.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  7. XM_054320069.1 → XP_054176044.1  zinc finger protein 780B isoform X1

  8. XM_054320077.1 → XP_054176052.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  9. XM_054320073.1 → XP_054176048.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  10. XM_054320070.1 → XP_054176045.1  zinc finger protein 780B isoform X1

  11. XM_054320078.1 → XP_054176053.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  12. XM_054320079.1 → XP_054176054.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  13. XM_054320080.1 → XP_054176055.1  zinc finger protein 780B isoform X2

    UniProtKB/Swiss-Prot
    B9EH00, Q9Y6R6

  14. XM_054320072.1 → XP_054176047.1  zinc finger protein 780B isoform X1

  15. XM_054320071.1 → XP_054176046.1  zinc finger protein 780B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6R6.1 GenPept UniProtKB/Swiss-Prot:Q9Y6R6

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