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CALML6 calmodulin like 6 [ Homo sapiens (human) ]

Gene ID: 163688, updated on 28-Oct-2024

Summary

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Official Symbol
CALML6provided by HGNC
Official Full Name
calmodulin like 6provided by HGNC
Primary source
HGNC:HGNC:24193
See related
Ensembl:ENSG00000169885 MIM:610171; AllianceGenome:HGNC:24193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAGLP
Summary
Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See CALML6 in Genome Data Viewer
Location:
1p36.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1915260..1917296)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1348173..1351716)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1846699..1848735)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 93 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 94 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 95 Neighboring gene GNB1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 96 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 97 Neighboring gene uncharacterized LOC124903822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 45 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 98 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1840895-1841864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1845520-1846206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1850035-1850836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1850896-1851489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1851490-1852082 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1853696-1853880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1854781-1855281 Neighboring gene transmembrane protein 52 Neighboring gene cilia and flagella associated protein 74 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1871092-1871328 Neighboring gene uncharacterized LOC107984872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1889089-1889729 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1889730-1890369

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of human CAGLP gene encoding a novel EF-hand protein. Chen S, et al. DNA Seq, 2004 Oct-Dec. PMID 15621662
  2. EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma. Ishikawa S, et al. Commun Biol, 2024 May 14. PMID 38745046, Free PMC Article
  3. The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Wang Z, et al. Cell Rep, 2019 Jan 29. PMID 30699354
  4. CALML6 Controls TAK1 Ubiquitination and Confers Protection against Acute Inflammation. Sheng C, et al. J Immunol, 2020 Jun 1. PMID 32303555
  5. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. Chiarini A, et al. Proteomics, 2009 Apr. PMID 19294699

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.
    Title: EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.
  2. The EF-hand protein calmodulin-like 6 (CALML6) directly bound to the phosphorylated serine-rich (SR) region of IRF3 and impaired its dimerization and nuclear translocation.
    Title: The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization.
  3. a novel human gene, CAGLP (calglandulin-like protein) was predicted, and subsequently isolated from human skeleton muscle
    Title: Cloning and characterization of human CAGLP gene encoding a novel EF-hand protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calmodulin-like protein 6
Names
EF-hand protein
calglandulin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330313.2 → NP_001317242.1  calmodulin-like protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL109917
    Consensus CDS
    CCDS81255.1
    UniProtKB/TrEMBL
    B1AKR1
    Related
    ENSP00000367867.3, ENST00000378604.3

  2. NM_138705.4 → NP_619650.2  calmodulin-like protein 6 isoform 1

    See identical proteins and their annotated locations for NP_619650.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF490905, AL109917
    Consensus CDS
    CCDS30566.1
    UniProtKB/Swiss-Prot
    A2A2M3, Q6Q2C4, Q8TD86
    Related
    ENSP00000304643.3, ENST00000307786.8
    Conserved Domains (2) summary
    PTZ00184
    Location:26 → 173
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:111 → 173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1915260..1917296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244729.4 → XP_005244786.2  calmodulin-like protein 6 isoform X1

    Conserved Domains (2) summary
    PTZ00184
    Location:48 → 195
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:133 → 195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    1348173..1351716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334736.1 → XP_054190711.1  calmodulin-like protein 6 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TD86.2 GenPept UniProtKB/Swiss-Prot:Q8TD86

Gene LinkOut

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