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Itm2a integral membrane protein 2A [ Mus musculus (house mouse) ]

Gene ID: 16431, updated on 2-Nov-2024

Summary

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Official Symbol
Itm2aprovided by MGI
Official Full Name
integral membrane protein 2Aprovided by MGI
Primary source
MGI:MGI:107706
See related
Ensembl:ENSMUSG00000031239 AllianceGenome:MGI:107706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E25; Itm2; Bricd2a
Summary
Predicted to enable amyloid-beta binding activity. Acts upstream of or within plasma cell differentiation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; eye; vascular element; and vault of skull. Orthologous to human ITM2A (integral membrane protein 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 309.6), placenta adult (RPKM 74.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Itm2a in Genome Data Viewer
Location:
X D; X 47.52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106440801..106446966, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107397195..107403360, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene glutamate dehydrogenase 1 pseudogene Neighboring gene ribosomal protein L7a pseudogene Neighboring gene STARR-seq mESC enhancer starr_47744 Neighboring gene STARR-seq mESC enhancer starr_47745 Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene STARR-seq mESC enhancer starr_47746 Neighboring gene T-box 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathway. Van den Plas D, et al. Biol Cell, 2004 Aug. PMID 15325075
  2. Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells. Kihara M, et al. PLoS One, 2014. PMID 25079563, Free PMC Article
  3. Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling. Morales-Alcala CC, et al. Cells, 2021 Aug 6. PMID 34440772, Free PMC Article
  4. Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation. Davies SJ, et al. Adipocyte, 2017 Oct 2. PMID 28872940, Free PMC Article
  5. Genomic organization and chromosomal localization of the Itm2a gene. Pittois K, et al. Mamm Genome, 1999 Jan. PMID 9892734

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling.
    Title: Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling.
  2. Itm2a knockdown is sufficient to rescue the inhibitory effects of lamin A WT and R482W mutant overexpression on 3T3-L1 differentiation.
    Title: Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation.
  3. Itm2a possesses diverse functional properties as evidenced by differential expression during odontogenesis.
    Title: Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells.
  4. Itm2a is a target gene of GATA-3 that plays a minimal role in regulating the development and function of T cells
    Title: Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells.
  5. Itm2a is not only expressed in adult muscle fibres but also in the satellite cells responsible for regeneration.
    Title: Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo.
  6. Both Itm2a and Itm2c were not detected in the epididymis and vas deferens during sexual maturation.
    Title: Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues.
  7. Results support the involvement of Itm2a in the early stages of chondrogenesis in vitro.
    Title: In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathway.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of amyloid precursor protein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within plasma cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integral membrane protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008409.2 → NP_032435.2  integral membrane protein 2A

    See identical proteins and their annotated locations for NP_032435.2

    Status: VALIDATED

    Source sequence(s)
    BQ568915, L38971
    Consensus CDS
    CCDS30349.1
    UniProtKB/Swiss-Prot
    Q3TJP5, Q61500, Q8K0H4, Q9CRW4
    Related
    ENSMUSP00000033591.6, ENSMUST00000033591.6
    Conserved Domains (1) summary
    smart01039
    Location:133 → 225
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    106440801..106446966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61500.2 GenPept UniProtKB/Swiss-Prot:Q61500

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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