U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Jrk jerky [ Mus musculus (house mouse) ]

Gene ID: 16469, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Jrkprovided by MGI
Official Full Name
jerkyprovided by MGI
Primary source
MGI:MGI:106214
See related
Ensembl:ENSMUSG00000046380 AllianceGenome:MGI:106214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables mRNA binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; early conceptus; eye; and genitourinary system. Orthologous to human JRK (Jrk helix-turn-helix protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 4.1), ovary adult (RPKM 2.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Jrk in Genome Data Viewer
Location:
15 D3; 15 34.26 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74574261..74581171, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74702412..74709322, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 4 Neighboring gene STARR-seq mESC enhancer starr_38988 Neighboring gene STARR-seq mESC enhancer starr_38991 Neighboring gene predicted gene, 32994 Neighboring gene activity regulated cytoskeletal-associated protein Neighboring gene STARR-seq mESC enhancer starr_38994 Neighboring gene RIKEN cDNA 4933427E11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:74553786-74554003 Neighboring gene prostate stem cell antigen Neighboring gene thioesterase superfamily member 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sensitivity to jerky gene dosage underlies epileptic seizures in mice. Donovan GP, et al. J Neurosci, 1997 Jun 15. PMID 9169517, Free PMC Article
  2. Mapping and positional cloning of common idiopathic generalized epilepsies: juvenile myoclonus epilepsy and childhood absence epilepsy. Delgado-Escueta AV, et al. Adv Neurol, 1999. PMID 10514826
  3. Complex regulation and nuclear localization of JRK protein. Waldron R, et al. Biochem Soc Trans, 2004 Dec. PMID 15506925
  4. The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs. Liu W, et al. Mol Cell Biol, 2003 Jun. PMID 12773553, Free PMC Article
  5. JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24. Morita R, et al. Biochem Biophys Res Commun, 1998 Jul 20. PMID 9675132

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JRK protein associates with a specific chromosomal centromeric locus in the cell cycle G(2) phase.
    Title: Complex regulation and nuclear localization of JRK protein.
  2. Jerky has a role in epilepsy and consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs
    Title: The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
jerky protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008415.6 → NP_032441.4  jerky protein

    See identical proteins and their annotated locations for NP_032441.4

    Status: VALIDATED

    Source sequence(s)
    AC118022, AK168885
    Consensus CDS
    CCDS27524.1
    UniProtKB/Swiss-Prot
    Q60976
    UniProtKB/TrEMBL
    Q543Z9, Q8C995
    Related
    ENSMUSP00000051842.3, ENSMUST00000050234.4
    Conserved Domains (3) summary
    smart00674
    Location:83 → 147
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam03184
    Location:213 → 382
    DDE_1; DDE superfamily endonuclease
    pfam04218
    Location:14 → 66
    CENP-B_N; CENP-B N-terminal DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    74574261..74581171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60976.2 GenPept UniProtKB/Swiss-Prot:Q60976

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools