Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcna2provided by MGI
Official Full Name: potassium voltage-gated channel, shaker-related subfamily, member 2provided by MGI
Primary source: MGI:MGI:96659
See related: Ensembl:ENSMUSG00000040724 AllianceGenome:MGI:96659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mk-2; Kv1.2; Akr6a4; Kca1-2; Gm10672
Summary: Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport; regulation of circadian sleep/wake cycle, non-REM sleep; and regulation of dopamine secretion. Acts upstream of or within optic nerve structural organization. Located in several cellular components, including axon; neuronal cell body membrane; and perikaryon. Part of voltage-gated potassium channel complex. Is active in axon initial segment. Is expressed in several structures, including brain; heart ventricle; and hindlimb muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in cerebellum adult (RPKM 17.1), cortex adult (RPKM 9.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.3; 3 46.61 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (106998203..107022321)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107090883..107115005)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons.
Title: Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons.
Sound Localization in Preweanling Mice Was More Severely Affected by Deleting the Kcna1 Gene Compared to Deleting Kcna2, and a Curious Inverted-U Course of Development That Appeared to Exceed Adult Performance Was Observed in All Groups.
Title: Sound Localization in Preweanling Mice Was More Severely Affected by Deleting the Kcna1 Gene Compared to Deleting Kcna2, and a Curious Inverted-U Course of Development That Appeared to Exceed Adult Performance Was Observed in All Groups.
Dorsal root ganglion (DRG) DNMT1 contributes to neuropathic pain genesis partially through repression of DRG Kcna2 gene expression
Title: Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.
Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations
Title: Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations.
G9a contributes to neuropathic pain development through epigenetic silencing of Kcna2 in the axotomized dorsal root ganglion.
Title: G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons.
Results show that MK2 activation induces MRTF-A phosphorylation at S351 and S371 upon stress.
Title: Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis.
Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells
Title: Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells.
analysis of fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics
Title: Fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics.
This study showed that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines.
Title: MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation.
Mk2 homozygous deletion in mice impedes the induction of experimental colitis by dextran sodium sulfate, confirming the notion that p38/Mk2 is involved in this inflammatory response.
Title: Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (5)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within optic nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in juxtaparanode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in paranodal junction	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 2

Names: MK2; voltage-gated potassium channel subunit Kv1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008417.5 → NP_032443.3 potassium voltage-gated channel subfamily A member 2

See identical proteins and their annotated locations for NP_032443.3

Status: VALIDATED

Source sequence(s)

AC121825, AI607461, AK044342

Consensus CDS

CCDS17733.1

UniProtKB/Swiss-Prot

B2RS05, P15386, P63141, Q02010, Q8C8W4

Related

ENSMUSP00000041702.2, ENSMUST00000038695.6

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

106998203..107022321

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501055.5 → XP_006501118.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006501118.1

UniProtKB/Swiss-Prot

B2RS05, P15386, P63141, Q02010, Q8C8W4

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_036162906.1 → XP_036018799.1 potassium voltage-gated channel subfamily A member 2 isoform X1

UniProtKB/Swiss-Prot

B2RS05, P15386, P63141, Q02010, Q8C8W4

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_006501049.5 → XP_006501112.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006501112.1

UniProtKB/Swiss-Prot

B2RS05, P15386, P63141, Q02010, Q8C8W4

Related

ENSMUSP00000143798.2, ENSMUST00000197470.5

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_006501052.5 → XP_006501115.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006501115.1

UniProtKB/Swiss-Prot

B2RS05, P15386, P63141, Q02010, Q8C8W4

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_006501051.5 → XP_006501114.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006501114.1

UniProtKB/Swiss-Prot

B2RS05, P15386, P63141, Q02010, Q8C8W4

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_006501053.5 → XP_006501116.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006501116.1

UniProtKB/Swiss-Prot

B2RS05, P15386, P63141, Q02010, Q8C8W4

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_006501050.4 → XP_006501113.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006501113.1

UniProtKB/Swiss-Prot

B2RS05, P15386, P63141, Q02010, Q8C8W4

Related

ENSMUSP00000142873.2, ENSMUST00000196403.2

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein