U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 [ Mus musculus (house mouse) ]

Gene ID: 16491, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Kcna3provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 3provided by MGI
Primary source
MGI:MGI:96660
See related
Ensembl:ENSMUSG00000047959 AllianceGenome:MGI:96660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mk-3; Kv1.3; Kca1-3
Summary
Enables voltage-gated potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in axon and plasma membrane. Is expressed in brain and heart. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kcna3 in Genome Data Viewer
Location:
3 F2.3; 3 46.59 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106943486..106947223)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107036162..107038129)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18162 Neighboring gene predicted gene, 27008 Neighboring gene STARR-seq mESC enhancer starr_08657 Neighboring gene STARR-seq mESC enhancer starr_08658 Neighboring gene STARR-positive B cell enhancer ABC_E826 Neighboring gene STARR-positive B cell enhancer ABC_E7936 Neighboring gene expressed sequence AI504432 Neighboring gene predicted gene, 38712 Neighboring gene STARR-positive B cell enhancer ABC_E4573 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106883731-106883985 Neighboring gene STARR-positive B cell enhancer ABC_E7937 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 2 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 10

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis. Gocke AR, et al. J Immunol, 2012 Jun 15. PMID 22581856, Free PMC Article
  2. Compensatory anion currents in Kv1.3 channel-deficient thymocytes. Koni PA, et al. J Biol Chem, 2003 Oct 10. PMID 12878608
  3. Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel. Kovach CP, et al. Front Physiol, 2016. PMID 27242550, Free PMC Article
  4. Kv1.3 channel blockade enhances the phagocytic function of RAW264.7 macrophages. Zhu H, et al. Sci China Life Sci, 2015 Sep. PMID 26354506
  5. Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties. Grishkan IV, et al. J Immunol, 2015 Aug 15. PMID 26150529, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell proliferation through JAK2/STAT3 signaling pathway.
    Title: Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell proliferation through JAK2/STAT3 signaling pathway.
  2. Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF-kappaB signaling pathway.
    Title: Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF-κB signaling pathway.
  3. The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation.
    Title: The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation.
  4. Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
    Title: Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
  5. The Kv1.3 ion channel acts as a host factor restricting viral entry.
    Title: The Kv1.3 ion channel acts as a host factor restricting viral entry.
  6. Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration.
    Title: Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration.
  7. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
    Title: Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
  8. Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.
    Title: Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.
  9. beta1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
    Title: β1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
  10. Long-term obesogenic diet and targeted deletion of potassium channel Kv 1.3 have differing effects on voluntary exercise in mice.
    Title: Long-term obesogenic diet and targeted deletion of potassium channel K(v) 1.3 have differing effects on voluntary exercise in mice.
Submit: New GeneRIF Correction See all GeneRIFs (57)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delayed rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables outward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in corpus callosum development IEA
Inferred from Electronic Annotation
more info
  
involved_in optic nerve development IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in calyx of Held IEA
Inferred from Electronic Annotation
more info
  
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
potassium voltage-gated channel subfamily A member 3
Names
MK3
Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3)
voltage-gated potassium channel subunit Kv1.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008418.3 → NP_032444.2  potassium voltage-gated channel subfamily A member 3

    See identical proteins and their annotated locations for NP_032444.2

    Status: VALIDATED

    Source sequence(s)
    AC121825
    Consensus CDS
    CCDS17730.1
    UniProtKB/Swiss-Prot
    A3KMM2, P16390
    Related
    ENSMUSP00000050680.4, ENSMUST00000052718.5
    Conserved Domains (4) summary
    smart00225
    Location:59 → 153
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:243 → 443
    Ion_trans; Ion transport protein
    pfam02214
    Location:59 → 150
    BTB_2; BTB/POZ domain
    pfam07885
    Location:357 → 434
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    106943486..106947223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16390.3 GenPept UniProtKB/Swiss-Prot:P16390

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous