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Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 16506, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnd1provided by MGI
Official Full Name
potassium voltage-gated channel, Shal-related family, member 1provided by MGI
Primary source
MGI:MGI:96671
See related
Ensembl:ENSMUSG00000009731 AllianceGenome:MGI:96671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Shal; Kv4.1; Shal1; Kca2-1; mShal1; 1110037K09Rik
Summary
This gene encodes a multipass transmembrane protein that comprises a subunit of voltage-gated rapidly inactivating A-type potassium channels. [provided by RefSeq, May 2015]
Expression
Broad expression in genital fat pad adult (RPKM 5.4), frontal lobe adult (RPKM 2.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnd1 in Genome Data Viewer
Location:
X A1.1; X 3.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7686907..7704517)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7823759..7838278)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene transcription factor E3 Neighboring gene predicted gene, 39487 Neighboring gene GRIP1 associated protein 1 Neighboring gene microRNA 1198 Neighboring gene STARR-seq mESC enhancer starr_46674 Neighboring gene OTU domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E11045 Neighboring gene proviral integration site 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. mShal, a subfamily of A-type K+ channel cloned from mammalian brain. Pak MD, et al. Proc Natl Acad Sci U S A, 1991 May 15. PMID 2034678, Free PMC Article
  2. The effects of putative K+ channel blockers on volume regulation of murine spermatozoa. Barfield JP, et al. Biol Reprod, 2005 May. PMID 15673604
  3. Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation. Kim KR, et al. Mol Brain, 2021 Mar 30. PMID 33785038, Free PMC Article
  4. Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation. Kim KR, et al. J Neurosci, 2020 Mar 11. PMID 32047055, Free PMC Article
  5. Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels. Wang G, et al. J Gen Physiol, 2005 Jul. PMID 15955876, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.
    Title: Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.
  2. Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation.
    Title: Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation.
  3. Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation.
    Title: Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation.
  4. Expression of the Kv4.1-targeted shRNA significantly decreased interspike intervals and increased repetitive firing rates in suprachiasmatic nucleus (SCN) neurons during the day and at night. results presented here also revealed that the acute knockdown of Kv4.1 had differential effects on the daytime and nighttime input resistance and repetitive firing rates in SCN neurons.
    Title: Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior.
  5. The complex voltage-dependent gating rearrangements of eukaryotic Kv channels are not limited to the membrane-spanning core but must include the intracellular T1-T1 interface.
    Title: Voltage-dependent gating rearrangements in the intracellular T1-T1 interface of a K+ channel.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables A-type (transient outward) potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables A-type (transient outward) potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
A-type voltage-gated potassium channel KCND1; potassium voltage-gated channel subfamily D member 1
Names
voltage-gated potassium channel subunit Kv4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008423.2 → NP_032449.1  A-type voltage-gated potassium channel KCND1

    See identical proteins and their annotated locations for NP_032449.1

    Status: REVIEWED

    Source sequence(s)
    AK033805, BC139325
    Consensus CDS
    CCDS29974.1
    UniProtKB/Swiss-Prot
    Q03719, Q8CC68
    UniProtKB/TrEMBL
    A2AEX0
    Related
    ENSMUSP00000009875.5, ENSMUST00000009875.5
    Conserved Domains (3) summary
    cl38908
    Location:6 → 143
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:185 → 417
    Ion_trans; Ion transport protein
    pfam11879
    Location:447 → 550
    DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7686907..7704517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161827.1 → XP_036017720.1  potassium voltage-gated channel subfamily D member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q03719, Q8CC68
    UniProtKB/TrEMBL
    A2AEX0
    Conserved Domains (3) summary
    cl38908
    Location:6 → 143
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:185 → 417
    Ion_trans; Ion transport protein
    pfam11879
    Location:447 → 550
    DUF3399; Domain of unknown function (DUF3399)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03719.1 GenPept UniProtKB/Swiss-Prot:Q03719

Gene LinkOut

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