Khsrp KH-type splicing regulatory protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Khsrpprovided by MGI
Official Full Name: KH-type splicing regulatory proteinprovided by MGI
Primary source: MGI:MGI:1336214
See related: Ensembl:ENSMUSG00000007670 AllianceGenome:MGI:1336214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbp2; Ksrp; Fubp2; 6330409F21Rik
Summary: Enables mRNA binding activity. Acts upstream of or within mRNA catabolic process and regulation of miRNA metabolic process. Located in cytoplasmic stress granule. Is expressed in several structures, including gonad; pancreas tip epithelium; and urinary system. Orthologous to human KHSRP (KH-type splicing regulatory protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 54.0), thymus adult (RPKM 53.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.63 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57328049..57338507, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (57021049..57031507, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1.
Title: KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1.
KSRP improves pancreatic beta cell function and survival.
Title: KSRP improves pancreatic beta cell function and survival.
KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization.
Title: KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization.
Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas(lpr) Mice.
Title: Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas(lpr) Mice.
FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells.
Title: FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells.
The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
Title: The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
Report KSRP/mRNA/microRNA interactions in chromatoid body of spermatids regulating spermatogenesis.
Title: KH-type splicing regulatory protein is a new component of chromatoid body.
CXCL-2 and HMOX-1 were upregulated in H. pylori infection after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori.
Title: Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.
IFN-gamma production was increased in spleen cells of KSRP(-/-) mice.
Title: Inactivation of the KSRP gene modifies collagen antibody induced arthritis.
Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1.
Title: Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126557 (e-PCR)
- UniSTS:209685

Khsrp (e-PCR), detects polymorphism
- UniSTS:143692

NoName (e-PCR)
- UniSTS:237675

AI507137 (e-PCR)
- UniSTS:165799

Khsrp (e-PCR), detects polymorphism
- UniSTS:525250

D17S802 (e-PCR), detects polymorphism
- UniSTS:48363

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in 3'-UTR-mediated mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in miRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in miRNA metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of miRNA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: far upstream element-binding protein 2

Names: FUSE-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010613.3 → NP_034743.3 far upstream element-binding protein 2

See identical proteins and their annotated locations for NP_034743.3

Status: VALIDATED

Source sequence(s)

BB258658, BB645370, BC108414, CB247078

Consensus CDS

CCDS50157.1

UniProtKB/Swiss-Prot

E9QKH3, Q2VPQ6, Q3U0V1, Q6P2L2

UniProtKB/TrEMBL

A0A3B2WCD8

Related

ENSMUSP00000007814.9, ENSMUST00000007814.10

Conserved Domains (3) summary

cd00105
Location:147 → 209

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:427 → 492

KH_1; KH domain

pfam09005
Location:672 → 686

DUF1897; Domain of unknown function (DUF1897)