Klk1b1 kallikrein 1-related peptidase b1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk1b1provided by MGI
Official Full Name: kallikrein 1-related peptidase b1provided by MGI
Primary source: MGI:MGI:892019
See related: Ensembl:ENSMUSG00000063133 AllianceGenome:MGI:892019
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mK1; Klk1; mGK-1
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]
Expression: Biased expression in colon adult (RPKM 2.1), kidney adult (RPKM 1.2) and 4 other tissues See more
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Genomic context

Location:: 7 B3; 7 28.44 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43616175..43620742)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43966751..43971318)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Klk1 (e-PCR), detects polymorphism
- UniSTS:143698

D7Mit26.2 (e-PCR), detects polymorphism
- UniSTS:131155

Ngfa (e-PCR), detects polymorphism
- UniSTS:144010

33.MMHAP81FRC12.seq (e-PCR)
- UniSTS:124052

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bradykinin biosynthetic process	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within tissue kallikrein-kinin cascade	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within vasodilation	IMP Inferred from Mutant Phenotype more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein 1-related peptidase b1

Names: glandular kallikrein K1

NP_034775.1

EC 3.4.21.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.