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DECR1 2,4-dienoyl-CoA reductase 1 [ Homo sapiens (human) ]

Gene ID: 1666, updated on 3-Nov-2024

Summary

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Official Symbol
DECR1provided by HGNC
Official Full Name
2,4-dienoyl-CoA reductase 1provided by HGNC
Primary source
HGNC:HGNC:2753
See related
Ensembl:ENSG00000104325 MIM:222745; AllianceGenome:HGNC:2753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DECR; NADPH; SDR18C1
Summary
Enables 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in fatty acid beta-oxidation. Located in cytosol; mitochondrion; and nucleoplasm. Part of catalytic complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver (RPKM 86.6), fat (RPKM 60.8) and 25 other tissues See more
Orthologs
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Genomic context

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See DECR1 in Genome Data Viewer
Location:
8q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (90001477..90053633)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (91125148..91177304)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (91013705..91065861)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901974 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90913443-90914208 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:90914502-90914800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19348 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:90959982-90961181 Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27608 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90996459-90997255 Neighboring gene Sharpr-MPRA regulatory region 13813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27611 Neighboring gene nibrin Neighboring gene uncharacterized LOC124901976 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:91107580-91108779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:91109970-91110642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:91110643-91111314 Neighboring gene calbindin 1 Neighboring gene GATA motif-containing MPRA enhancer 124 Neighboring gene CRISPRi-validated cis-regulatory element chr8.2225 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:91227356-91227995 Neighboring gene long intergenic non-protein coding RNA 534 Neighboring gene uncharacterized LOC124901975

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NADPH-dependent beta-oxidation of unsaturated fatty acids with double bonds extending from odd-numbered carbon atoms. Smeland TE, et al. Proc Natl Acad Sci U S A, 1992 Aug 1. PMID 1495956, Free PMC Article
  2. Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation. Arai Y, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24326071
  3. 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Blomme A, et al. Nat Commun, 2020 May 19. PMID 32427840, Free PMC Article
  4. Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. Nassar ZD, et al. Elife, 2020 Jul 20. PMID 32686647, Free PMC Article
  5. Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes. Kardon T, et al. FEBS Lett, 2008 Jun 11. PMID 18472006

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DECR1 directly activates HSL to promote lipolysis in cervical cancer cells.
    Title: DECR1 directly activates HSL to promote lipolysis in cervical cancer cells.
  2. Reduced 2,4-dienoyl-CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer.
    Title: Reduced 2,4-dienoyl-CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer.
  3. NADPH Oxidases in the Central Nervous System: Regional and Cellular Localization and the Possible Link to Brain Diseases.
    Title: NADPH Oxidases in the Central Nervous System: Regional and Cellular Localization and the Possible Link to Brain Diseases.
  4. Association of whole mtDNA, an NADPH G11914A variant, and haplogroups with high physical performance in an elite military troop.
    Title: Association of whole mtDNA, an NADPH G11914A variant, and haplogroups with high physical performance in an elite military troop.
  5. Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.
    Title: Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.
  6. 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
    Title: 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
  7. Our study is the first to demonstrate the novel function of UA in NET formation and may provide insight into the management of patients with hyperuricemia.
    Title: Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation.
  8. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
    Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
Names
2,4-dienoyl-CoA reductase 1, mitochondrial
2,4-dienoyl-CoA reductase, mitochondrial
4-enoyl-CoA reductase
short chain dehydrogenase/reductase family 18C member 1
NP_001317504.1
NP_001350.1
XP_005250865.1
XP_011515182.1
XP_047277365.1
XP_047277366.1
XP_054215840.1
XP_054215841.1
XP_054215842.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008042.2 RefSeqGene

    Range
    5001..57157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330575.2 → NP_001317504.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform 2

    Status: REVIEWED

    Source sequence(s)
    AA725334, AC004612, AF069291, AK300069
    Consensus CDS
    CCDS87618.1
    UniProtKB/Swiss-Prot
    Q16698
    Related
    ENSP00000429779.1, ENST00000522161.5

  2. NM_001359.2 → NP_001350.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001350.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA725334, AC004612, BC105080, CB104585, CR737790, H98841
    Consensus CDS
    CCDS6250.1
    UniProtKB/Swiss-Prot
    B7Z6B8, Q16698, Q2M304, Q93085
    Related
    ENSP00000220764.2, ENST00000220764.7
    Conserved Domains (1) summary
    cd05369
    Location:57 → 303
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    90001477..90053633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421410.1 → XP_047277366.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X2

  2. XM_011516880.4 → XP_011515182.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X2

    Conserved Domains (2) summary
    cd05369
    Location:48 → 294
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK07576
    Location:48 → 293
    PRK07576; short chain dehydrogenase; Provisional

  3. XM_005250808.6 → XP_005250865.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X3

    Conserved Domains (1) summary
    cd05369
    Location:1 → 211
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

  4. XM_047421409.1 → XP_047277365.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    91125148..91177304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359866.1 → XP_054215841.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X2

  2. XM_054359867.1 → XP_054215842.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X3

  3. XM_054359865.1 → XP_054215840.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16698.1 GenPept UniProtKB/Swiss-Prot:Q16698

Gene LinkOut

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