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DCLK2 doublecortin like kinase 2 [ Homo sapiens (human) ]

Gene ID: 166614, updated on 6-Jun-2024

Summary

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Official Symbol
DCLK2provided by HGNC
Official Full Name
doublecortin like kinase 2provided by HGNC
Primary source
HGNC:HGNC:19002
See related
Ensembl:ENSG00000170390 MIM:613166; AllianceGenome:HGNC:19002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II
Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
Expression
Biased expression in brain (RPKM 21.2), heart (RPKM 3.5) and 9 other tissues See more
Orthologs
mouse all
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Genomic context

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See DCLK2 in Genome Data Viewer
Location:
4q31.23-q31.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (150078445..150257438)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (153399764..153581437)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (150999597..151178590)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 167 Neighboring gene RNA, U6 small nuclear 1230, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14262 Neighboring gene VISTA enhancer hs1614 Neighboring gene RNA, U7 small nuclear 194 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:151209299-151209799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22014 Neighboring gene Sharpr-MPRA regulatory region 13510 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:151287541-151288222 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:151288223-151288903 Neighboring gene LPS responsive beige-like anchor protein Neighboring gene nei like DNA glycosylase 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5429 Neighboring gene uncharacterized LOC729558

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene. Gorelik A, et al. Cell Mol Biol Lett, 2008. PMID 18618084, Free PMC Article
  2. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. Edelman AM, et al. J Biol Chem, 2005 Mar 4. PMID 15611072
  3. Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation. Shin E, et al. Nat Commun, 2013. PMID 23385585, Free PMC Article
  4. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Nawabi H, et al. Neuron, 2015 Nov 18. PMID 26526391, Free PMC Article
  5. The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis. Song J, et al. J Biol Chem, 2021 Jan-Jun. PMID 33199366, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
    Title: Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study of autistic-like traits in a general population study of young adults.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45428, DKFZp761I032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in pyramidal neuron development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase DCLK2
Names
CaMK-like CREB regulatory kinase 2
doublecortin and CaM kinase-like 2
doublecortin domain-containing protein 3B
doublecortin-like and CAM kinase-like 2
NP_001035350.2
NP_001035351.4
NP_001397781.1
XP_005262842.1
XP_016863321.1
XP_016863322.1
XP_024309681.1
XP_024309682.1
XP_024309683.1
XP_047305657.1
XP_047305658.1
XP_054205063.1
XP_054205064.1
XP_054205065.1
XP_054205066.1
XP_054205067.1
XP_054205068.1
XP_054205069.1
XP_054205070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040260.4 → NP_001035350.2  serine/threonine-protein kinase DCLK2 isoform a

    See identical proteins and their annotated locations for NP_001035350.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is known as exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon in the 5' region, as compared to variant 2. The resulting isoform (a) lacks an internal segment, as compared to isoform b.
    Source sequence(s)
    AB209181, AC093748, AI419589, DA122884
    Consensus CDS
    CCDS34076.1
    UniProtKB/Swiss-Prot
    C9J5Q9, Q59GC8, Q8N399, Q8N568
    UniProtKB/TrEMBL
    A0A0U1RR70
    Related
    ENSP00000296550.7, ENST00000296550.12
    Conserved Domains (3) summary
    smart00220
    Location:394 → 651
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cd14184
    Location:392 → 650
    STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

  2. NM_001040261.5 → NP_001035351.4  serine/threonine-protein kinase DCLK2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is known as exon-5-containing transcript (PMIDs:15611072 and 18075264) and encodes the longer isoform (b).
    Source sequence(s)
    AC093748, AC105343, AL834498
    Consensus CDS
    CCDS47142.2
    UniProtKB/TrEMBL
    A0A0U1RR70
    Related
    ENSP00000303887.8, ENST00000302176.8
    Conserved Domains (3) summary
    smart00220
    Location:411 → 668
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cd14184
    Location:409 → 667
    STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

  3. NM_001410852.1 → NP_001397781.1  serine/threonine-protein kinase DCLK2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC093748, AC105343, AC118064
    Consensus CDS
    CCDS93647.1
    UniProtKB/TrEMBL
    A0A0U1RR70
    Related
    ENSP00000427235.1, ENST00000506325.5

RNA

  1. NR_036614.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is known as exon-17/16-containing transcript (PMIDs:15611072 and 18075264). It has an alternate splice site in the middle region, resulting in 3 nts missing, and has an additional exon in the 3' region, which includes a translation stop codon and results in a nonsense-mediated mRNA decay candidate, as compared to variant 2. This transcript is developmentally regulated and most probably does not make a protein.
    Source sequence(s)
    AC093748, AC105343, BC032726
    Related
    ENST00000411937.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    150078445..150257438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007832.3 → XP_016863321.1  serine/threonine-protein kinase DCLK2 isoform X2

    UniProtKB/TrEMBL
    A0A0U1RR70
    Related
    ENSP00000489372.1, ENST00000635524.1
    Conserved Domains (3) summary
    cd14184
    Location:409 → 667
    STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)
    cd17069
    Location:193 → 276
    DCX2; Dublecortin-like domain 2
    cd17141
    Location:70 → 154
    DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

  2. XM_017007833.3 → XP_016863322.1  serine/threonine-protein kinase DCLK2 isoform X3

    UniProtKB/TrEMBL
    A0A0U1RR70

  3. XM_005262785.4 → XP_005262842.1  serine/threonine-protein kinase DCLK2 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RR70
    Conserved Domains (3) summary
    smart00220
    Location:410 → 667
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cd14184
    Location:408 → 666
    STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

  4. XM_024453913.2 → XP_024309681.1  serine/threonine-protein kinase DCLK2 isoform X4

    UniProtKB/TrEMBL
    A0A0U1RR70
    Conserved Domains (2) summary
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:392 → 561
    PKc_like; Protein Kinases, catalytic domain

  5. XM_024453914.2 → XP_024309682.1  serine/threonine-protein kinase DCLK2 isoform X5

    UniProtKB/TrEMBL
    A0A0U1RR70
    Conserved Domains (2) summary
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:391 → 591
    PKc_like; Protein Kinases, catalytic domain

  6. XM_024453915.2 → XP_024309683.1  serine/threonine-protein kinase DCLK2 isoform X6

    UniProtKB/TrEMBL
    A0A0U1RR70
    Conserved Domains (2) summary
    smart00537
    Location:67 → 157
    DCX; Domain in the Doublecortin (DCX) gene product
    cl21453
    Location:409 → 584
    PKc_like; Protein Kinases, catalytic domain

  7. XM_047449701.1 → XP_047305657.1  serine/threonine-protein kinase DCLK2 isoform X7

  8. XM_047449702.1 → XP_047305658.1  serine/threonine-protein kinase DCLK2 isoform X8

RNA

  1. XR_007096380.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    153399764..153581437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349089.1 → XP_054205064.1  serine/threonine-protein kinase DCLK2 isoform X2

    UniProtKB/TrEMBL
    A0A0U1RR70

  2. XM_054349090.1 → XP_054205065.1  serine/threonine-protein kinase DCLK2 isoform X3

    UniProtKB/TrEMBL
    A0A0U1RR70

  3. XM_054349088.1 → XP_054205063.1  serine/threonine-protein kinase DCLK2 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RR70

  4. XM_054349091.1 → XP_054205066.1  serine/threonine-protein kinase DCLK2 isoform X4

    UniProtKB/TrEMBL
    A0A0U1RR70

  5. XM_054349092.1 → XP_054205067.1  serine/threonine-protein kinase DCLK2 isoform X5

    UniProtKB/TrEMBL
    A0A0U1RR70

  6. XM_054349093.1 → XP_054205068.1  serine/threonine-protein kinase DCLK2 isoform X6

    UniProtKB/TrEMBL
    A0A0U1RR70

  7. XM_054349094.1 → XP_054205069.1  serine/threonine-protein kinase DCLK2 isoform X7

  8. XM_054349095.1 → XP_054205070.1  serine/threonine-protein kinase DCLK2 isoform X8

RNA

  1. XR_008486943.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152619.1: Suppressed sequence

    Description
    NM_152619.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N568.4 GenPept UniProtKB/Swiss-Prot:Q8N568

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