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Gzmm granzyme M (lymphocyte met-ase 1) [ Mus musculus (house mouse) ]

Gene ID: 16904, updated on 2-Nov-2024

Summary

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Official Symbol
Gzmmprovided by MGI
Official Full Name
granzyme M (lymphocyte met-ase 1)provided by MGI
Primary source
MGI:MGI:99549
See related
Ensembl:ENSMUSG00000054206 AllianceGenome:MGI:99549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmet1; MMET-1
Summary
The protein encoded by this gene is a member of a family of cytotoxic lymphocyte serine proteases called granzymes, which are expressed by cytotoxic T lymphocytes and natural killer cells. This protein belongs to a subfamily of granzymes that cleave after methionine residues. Natural killer cell development, homeostasis and cytotoxicity are normal in mice deficient for this gene, but they demonstrate increased susceptibility to murine cytomegalovirus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in heart adult (RPKM 1.8), placenta adult (RPKM 0.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Gzmm in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79524854..79531095)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79689020..79695261)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E3896 Neighboring gene cell division cycle 34 Neighboring gene STARR-positive B cell enhancer ABC_E10624 Neighboring gene predicted gene, 25794 Neighboring gene basigin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Granzyme M cannot induce cell death via cleavage of mouse FADD. de Poot SA, et al. Apoptosis, 2013 Apr. PMID 23354943
  2. Cloning and expression of the recombinant mouse natural killer cell granzyme Met-ase-1. Kelly JM, et al. Immunogenetics, 1996. PMID 8781119
  3. High expression of alternative transcript of granzyme M in the mouse retina. Taniguchi M, et al. Neurosci Res, 1999 Jul. PMID 10498337
  4. Human and mouse granzyme M display divergent and species-specific substrate specificities. de Poot SA, et al. Biochem J, 2011 Aug 1. PMID 21564021
  5. Granzyme M has a critical role in providing innate immune protection in ulcerative colitis. Souza-Fonseca-Guimaraes F, et al. Cell Death Dis, 2016 Jul 21. PMID 27441655, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
granzyme M
Names
lymphoctye Met-ase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302485.1 → NP_001289414.1  granzyme M isoform 2 precursor

    See identical proteins and their annotated locations for NP_001289414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) utilizes an alternate in-frame splice site in the 5' coding region. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC151828, BG082217, CD742060
    UniProtKB/TrEMBL
    B7ZP17
    Conserved Domains (2) summary
    smart00020
    Location:26 → 250
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:26 → 253
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001302499.2 → NP_001289428.1  granzyme M isoform 3

    See identical proteins and their annotated locations for NP_001289428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR, lacks exons in the coding region, and utilizes a downstream start codon compared to variant 1. It encodes isoform 3, which is shorter than isoform 1. Variants 3 and 6-9 all encode the same isoform (3).
    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    Q9R1W7
    Related
    ENSMUST00000151213.2
    Conserved Domains (1) summary
    cl21584
    Location:2 → 100
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_001428556.1 → NP_001415485.1  granzyme M isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC151828

  4. NM_001428558.1 → NP_001415487.1  granzyme M isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC151828

  5. NM_001428559.1 → NP_001415488.1  granzyme M isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC151828

  6. NM_001428560.1 → NP_001415489.1  granzyme M isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC151828

  7. NM_001428561.1 → NP_001415490.1  granzyme M isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC151828

  8. NM_008504.3 → NP_032530.1  granzyme M isoform 1 precursor

    See identical proteins and their annotated locations for NP_032530.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC151828, BG082217, CD742060
    Consensus CDS
    CCDS23984.1
    UniProtKB/TrEMBL
    O08643
    Related
    ENSMUSP00000020549.3, ENSMUST00000020549.4
    Conserved Domains (2) summary
    smart00020
    Location:27 → 251
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:27 → 254
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_126325.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC151828, BE859680, BG082217, CD742060

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79524854..79531095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313816.3 → XP_017169305.1  granzyme M isoform X1

    Conserved Domains (1) summary
    cl21584
    Location:2 → 100
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_006513277.4 → XP_006513340.1  granzyme M isoform X1

    Conserved Domains (1) summary
    cl21584
    Location:2 → 100
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version

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