Lst1 leukocyte specific transcript 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lst1provided by MGI
Official Full Name: leukocyte specific transcript 1provided by MGI
Primary source: MGI:MGI:1096324
See related: Ensembl:ENSMUSG00000073412 AllianceGenome:MGI:1096324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B144
Summary: Involved in dendrite development. Predicted to be located in cytosol and plasma membrane. Predicted to be active in membrane. Is expressed in ductus deferens; epididymis; ileum; prostate gland; and spleen. Human ortholog(s) of this gene implicated in graft-versus-host disease. Orthologous to human LST1 (leukocyte specific transcript 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 30.2), liver E18 (RPKM 21.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.59 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35404071..35407416, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35185095..35188440, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.
Title: Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.
The absence of Lst1 leads to a slightly more susceptible phenotype. However, deletion of Lst1 in DBA/2 J mice alone does not explain the high susceptibility of this strain to PR8M influenza infections.
Title: Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

Lst1 (e-PCR), detects polymorphism
- UniSTS:143792

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lymphocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leukocyte-specific transcript 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.