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FUT11 fucosyltransferase 11 [ Homo sapiens (human) ]

Gene ID: 170384, updated on 30-Oct-2024

Summary

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Official Symbol
FUT11provided by HGNC
Official Full Name
fucosyltransferase 11provided by HGNC
Primary source
HGNC:HGNC:19233
See related
Ensembl:ENSG00000196968 MIM:616932; AllianceGenome:HGNC:19233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FUCTXI
Summary
Enables fucosyltransferase activity. Involved in N-glycan fucosylation. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Implicated in stomach cancer. Biomarker of stomach cancer. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in placenta (RPKM 8.2), lung (RPKM 6.0) and 24 other tissues See more
Orthologs
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Genomic context

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See FUT11 in Genome Data Viewer
Location:
10q22.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73772276..73780254)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74643692..74651652)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75532034..75535977)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902453 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:75503472-75504671 Neighboring gene SEC24 homolog C, COPII coat complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75532921-75533451 Neighboring gene uncharacterized LOC107984243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3575 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma. Zhang P, et al. Int Immunopharmacol, 2022 Dec. PMID 36403525
  2. FUT11 is a target gene of HIF1α that promotes the progression of hepatocellular carcinoma. Ruan W, et al. Cell Biol Int, 2021 Nov. PMID 34288238
  3. FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data. Zodro E, et al. Tumour Biol, 2014 Mar. PMID 24318988, Free PMC Article
  4. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). Mollicone R, et al. J Biol Chem, 2009 Feb 13. PMID 19088067
  5. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma.
    Title: Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma.
  2. FUT11 is a target gene of HIF1alpha that promotes the progression of hepatocellular carcinoma.
    Title: FUT11 is a target gene of HIF1α that promotes the progression of hepatocellular carcinoma.
  3. FUT11's expression might be potentially used as a biomarker of disease progression in clear cell renal cell carcinoma
    Title: FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data.
  4. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
    Title: Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33202, MGC119338, MGC119339

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-(1,3)-fucosyltransferase 11
Names
alpha (1,3) fucosyltransferase
fuc-TXI
fucT-XI
fucosyltransferase XI
galactoside 3-L-fucosyltransferase 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284194.2 → NP_001271123.1  alpha-(1,3)-fucosyltransferase 11 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001271123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC022400, BC036037, BC100994
    Consensus CDS
    CCDS60558.1
    UniProtKB/TrEMBL
    B2RC53
    Related
    ENSP00000378270.1, ENST00000394790.2
    Conserved Domains (2) summary
    pfam00852
    Location:216 → 355
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:77 → 176
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  2. NM_173540.3 → NP_775811.2  alpha-(1,3)-fucosyltransferase 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_775811.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC022400, BC036037, BC100997
    Consensus CDS
    CCDS7333.1
    UniProtKB/Swiss-Prot
    Q495W5, Q495W7, Q8IYE4
    UniProtKB/TrEMBL
    B2RC53
    Related
    ENSP00000361932.3, ENST00000372841.8
    Conserved Domains (2) summary
    pfam00852
    Location:216 → 355
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:77 → 176
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73772276..73780254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717656.5 → XP_006717719.1  alpha-(1,3)-fucosyltransferase 11 isoform X1

    UniProtKB/TrEMBL
    B2RC53
    Conserved Domains (2) summary
    pfam00852
    Location:216 → 355
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:77 → 176
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  2. XM_047424688.1 → XP_047280644.1  alpha-(1,3)-fucosyltransferase 11 isoform X2

  3. XM_047424689.1 → XP_047280645.1  alpha-(1,3)-fucosyltransferase 11 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74643692..74651652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364938.1 → XP_054220913.1  alpha-(1,3)-fucosyltransferase 11 isoform X1

  2. XM_054364939.1 → XP_054220914.1  alpha-(1,3)-fucosyltransferase 11 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q495W5.1 GenPept UniProtKB/Swiss-Prot:Q495W5

Gene LinkOut

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