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ACTL10 actin like 10 [ Homo sapiens (human) ]

Gene ID: 170487, updated on 11-Apr-2024

Summary

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Official Symbol
ACTL10provided by HGNC
Official Full Name
actin like 10provided by HGNC
Primary source
HGNC:HGNC:16127
See related
Ensembl:ENSG00000288649 AllianceGenome:HGNC:16127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ63M2.2; C20orf134
Summary
Predicted to be part of dynactin complex. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
mouse all
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Genomic context

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Location:
20q11.22
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (33666943..33668525)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (35393474..35395056)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (32254749..32256331)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12813 Neighboring gene CBFA2/RUNX1 partner transcriptional co-repressor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32104950-32105714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:32115920-32116420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:32116421-32116921 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:32118677-32119177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:32121705-32122204 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:32124101-32124819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17735 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:32144891-32145546 Neighboring gene Sharpr-MPRA regulatory region 10659 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32156001-32156927 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:32169053-32169552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32169790-32170374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32170375-32170958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:32175233-32175732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32240942-32241530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:32244101-32244601 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32250716-32251654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32251655-32252591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17739 Neighboring gene chromosome 20 open reading frame 144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32259897-32260446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32260995-32261542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32261543-32262090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:32262761-32263261 Neighboring gene N-terminal EF-hand calcium binding protein 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32267321-32267940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32267941-32268559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12820 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:32287672-32288382 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:32288383-32289094 Neighboring gene E2F transcription factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17741 Neighboring gene peroxisomal membrane protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
actin-like protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024675.2 → NP_001019846.1  actin-like protein 10

    See identical proteins and their annotated locations for NP_001019846.1

    Status: VALIDATED

    Source sequence(s)
    AW006704, BC137111
    Consensus CDS
    CCDS33463.1
    UniProtKB/Swiss-Prot
    B9EH76, Q5JWF8
    Related
    ENSP00000504425.1, ENST00000677665.1
    Conserved Domains (1) summary
    cl17037
    Location:2 → 237
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    33666943..33668525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    35393474..35395056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JWF8.1 GenPept UniProtKB/Swiss-Prot:Q5JWF8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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