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Ifi27 interferon, alpha-inducible protein 27 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170512, updated on 17-Aug-2024

Summary

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Official Symbol
Ifi27provided by RGD
Official Full Name
interferon, alpha-inducible protein 27provided by RGD
Primary source
RGD:69404
See related
EnsemblRapid:ENSRNOG00000009263 AllianceGenome:RGD:69404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IRG1; Ifi27l; Ifi27l1; isg12(a)
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Involved in maternal process involved in female pregnancy; response to cytokine; and response to estradiol. Predicted to be located in mitochondrial membrane and nuclear inner membrane. Predicted to be active in mitochondrion. Orthologous to human IFI27 (interferon alpha inducible protein 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 3236.1), Adrenal (RPKM 3024.9) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128355312..128361783)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122590461..122596996)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127327959..127334430)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene DEAD-box helicase 24 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene uncharacterized LOC108351293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and implantation stage-specific expression of an interferon-alpha-regulated gene in human and rat endometrium. Li Q, et al. Endocrinology, 2001 Jun. PMID 11356686
  2. ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis. Chen Y, et al. Virus Res, 2017 Jan 2. PMID 27777077
  3. Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a. Rosebeck S, et al. Apoptosis, 2008 Apr. PMID 18330707
  4. The interferon alpha induced protein ISG12 is localized to the nuclear membrane. Martensen PM, et al. Eur J Biochem, 2001 Nov. PMID 11722583
  5. miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT. Liu N, et al. Oncotarget, 2014 Jul 15. PMID 24970806, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in modulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cytokine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon alpha-inducible protein 27
Names
interferon, alpha-inducible protein 27 like 1
putative ISG12(a) protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433386.1 → NP_001420315.1  interferon alpha-inducible protein 27

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  2. NM_203410.2 → NP_981955.2  interferon alpha-inducible protein 27

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOP00000081720.2, ENSRNOT00000095734.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    128355312..128361783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261494.1 → XP_063117564.1  interferon alpha-inducible protein 27 isoform X1

    UniProtKB/TrEMBL
    A6JEN2, D3ZIG6, G3V761
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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