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Mark3 microtubule affinity regulating kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170577, updated on 10-Jul-2024

Summary

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Official Symbol
Mark3provided by RGD
Official Full Name
microtubule affinity regulating kinase 3provided by RGD
Primary source
RGD:619883
See related
EnsemblRapid:ENSRNOG00000010330 AllianceGenome:RGD:619883
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; peptidyl-serine autophosphorylation; and positive regulation of protein binding activity. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 238.7), Brain (RPKM 224.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mark3 in Genome Data Viewer
Location:
6q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136447327..136537409)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130626612..130716245)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136040957..136129780)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103627 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene eukaryotic translation initiation factor 5 Neighboring gene carnitine palmitoyltransferase 1A like 1 Neighboring gene tRNA methyltransferase 61A Neighboring gene creatine kinase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Moravcevic K, et al. Cell, 2010 Dec 10. PMID 21145462, Free PMC Article
  2. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Dequiedt F, et al. Mol Cell Biol, 2006 Oct. PMID 16980613, Free PMC Article
  3. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Peng CY, et al. Cell Growth Differ, 1998 Mar. PMID 9543386
  4. Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. Gu GJ, et al. Neuromolecular Med, 2013 Sep. PMID 23666762
  5. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Kwan J, et al. Genes Dev, 2016 Dec 15. PMID 28087714, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of hippo signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MAP/microtubule affinity-regulating kinase 3
NP_570105.1
XP_006240625.1
XP_017449499.2
XP_017449500.2
XP_038967643.1
XP_038967645.1
XP_038967646.1
XP_038967648.1
XP_038967649.1
XP_038967651.1
XP_038967652.1
XP_038967653.1
XP_063117565.1
XP_063117566.1
XP_063117567.1
XP_063117568.1
XP_063117569.1
XP_063117570.1
XP_063117571.1
XP_063117572.1
XP_063117573.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130749.1 → NP_570105.1  MAP/microtubule affinity-regulating kinase 3

    See identical proteins and their annotated locations for NP_570105.1

    Status: PROVISIONAL

    Source sequence(s)
    AF465412
    UniProtKB/Swiss-Prot
    Q8VHF0
    UniProtKB/TrEMBL
    A0A0G2K554
    Related
    ENSRNOP00000073297.1, ENSRNOT00000088784.4
    Conserved Domains (4) summary
    cd12196
    Location:698 → 795
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    136447327..136537409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111723.2 → XP_038967651.1  MAP/microtubule affinity-regulating kinase 3 isoform X18

    Conserved Domains (2) summary
    cd14407
    Location:406 → 448
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:136 → 388
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  2. XM_063261495.1 → XP_063117565.1  MAP/microtubule affinity-regulating kinase 3 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JU56

  3. XM_063261496.1 → XP_063117566.1  MAP/microtubule affinity-regulating kinase 3 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JU56

  4. XM_006240563.5 → XP_006240625.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

    See identical proteins and their annotated locations for XP_006240625.1

    UniProtKB/TrEMBL
    A0A0G2K554
    Conserved Domains (4) summary
    cd12196
    Location:707 → 804
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  5. XM_063261497.1 → XP_063117567.1  MAP/microtubule affinity-regulating kinase 3 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JU56

  6. XM_063261498.1 → XP_063117568.1  MAP/microtubule affinity-regulating kinase 3 isoform X11

    UniProtKB/TrEMBL
    A0A0G2JU56

  7. XM_063261500.1 → XP_063117570.1  MAP/microtubule affinity-regulating kinase 3 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JU56, A0A8I6GIW6
    Related
    ENSRNOP00000068972.3, ENSRNOT00000080304.3

  8. XM_039111721.2 → XP_038967649.1  MAP/microtubule affinity-regulating kinase 3 isoform X12

    UniProtKB/TrEMBL
    A0A0G2K554
    Conserved Domains (3) summary
    cd12196
    Location:643 → 740
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:261 → 303
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:18 → 243
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  9. XM_063261502.1 → XP_063117572.1  MAP/microtubule affinity-regulating kinase 3 isoform X16

    UniProtKB/TrEMBL
    A0A0G2JU56

  10. XM_063261503.1 → XP_063117573.1  MAP/microtubule affinity-regulating kinase 3 isoform X17

    UniProtKB/TrEMBL
    A0A0G2JU56

  11. XM_063261501.1 → XP_063117571.1  MAP/microtubule affinity-regulating kinase 3 isoform X15

    UniProtKB/TrEMBL
    A0A0G2K554

  12. XM_039111718.2 → XP_038967646.1  MAP/microtubule affinity-regulating kinase 3 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K554, F1M836
    Related
    ENSRNOP00000014395.4, ENSRNOT00000014395.6
    Conserved Domains (3) summary
    cd12196
    Location:699 → 796
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:317 → 359
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:47 → 299
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  13. XM_063261499.1 → XP_063117569.1  MAP/microtubule affinity-regulating kinase 3 isoform X13

    UniProtKB/TrEMBL
    A0A0G2JU56

  14. XM_017594011.3 → XP_017449500.2  MAP/microtubule affinity-regulating kinase 3 isoform X2

    UniProtKB/TrEMBL
    A6KBR9
    Conserved Domains (3) summary
    cd12196
    Location:577 → 674
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:219 → 261
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

  15. XM_017594010.3 → XP_017449499.2  MAP/microtubule affinity-regulating kinase 3 isoform X1

    UniProtKB/TrEMBL
    A6KBR9
    Conserved Domains (3) summary
    cd12196
    Location:585 → 682
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:219 → 261
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

  16. XM_039111715.1 → XP_038967643.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JU56
    Conserved Domains (3) summary
    cd12196
    Location:532 → 629
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:219 → 261
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

  17. XM_039111717.1 → XP_038967645.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JU56
    Conserved Domains (3) summary
    cd12196
    Location:523 → 620
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:219 → 261
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

  18. XM_039111720.1 → XP_038967648.1  MAP/microtubule affinity-regulating kinase 3 isoform X9

    Conserved Domains (4) summary
    cd12196
    Location:469 → 566
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    PHA03307
    Location:239 → 419
    PHA03307; transcriptional regulator ICP4; Provisional
    cd14407
    Location:140 → 182
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1 → 122
    PKc_like; Protein Kinases, catalytic domain

  19. XM_039111724.2 → XP_038967652.1  MAP/microtubule affinity-regulating kinase 3 isoform X19

    Conserved Domains (1) summary
    cd12196
    Location:359 → 456
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

  20. XM_039111725.2 → XP_038967653.1  MAP/microtubule affinity-regulating kinase 3 isoform X20

    Conserved Domains (1) summary
    cd12196
    Location:343 → 440
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHF0.1 GenPept UniProtKB/Swiss-Prot:Q8VHF0

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