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Klrb1c killer cell lectin-like receptor subfamily B member 1C [ Mus musculus (house mouse) ]

Gene ID: 17059, updated on 28-Oct-2024

Summary

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Official Symbol
Klrb1cprovided by MGI
Official Full Name
killer cell lectin-like receptor subfamily B member 1Cprovided by MGI
Primary source
MGI:MGI:107538
See related
Ensembl:ENSMUSG00000030325 AllianceGenome:MGI:107538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nk1; Ly59; Nk-1; CD161; Ly-59; Ly55c; NK1.1; NKRP1; Nk1.2; Klrb1b; NK-RP1; Nk-1.2; Nkrp1b; Nkrp1c; ly-55c; NKRP140; NKR-P1.9
Summary
Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Is expressed in thymus primordium. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in genital fat pad adult (RPKM 16.6) and spleen adult (RPKM 2.1) See more
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Genomic context

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See Klrb1c in Genome Data Viewer
Location:
6 F3; 6 63.09 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128755448..128765514, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128778485..128788641, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17454 Neighboring gene C-type lectin domain family 2, member h Neighboring gene STARR-seq mESC enhancer starr_17455 Neighboring gene killer cell lectin-like receptor subfamily B member 1 Neighboring gene STARR-seq mESC enhancer starr_17456 Neighboring gene STARR-seq mESC enhancer starr_17457 Neighboring gene STARR-seq mESC enhancer starr_17458 Neighboring gene STARR-positive B cell enhancer ABC_E238 Neighboring gene STARR-seq mESC enhancer starr_17462 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:128749513-128749622 Neighboring gene STARR-positive B cell enhancer ABC_E284 Neighboring gene predicted gene, 34755 Neighboring gene killer cell lectin-like receptor subfamily B member 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Natural killer T-cell populations in C57BL/6 and NK1.1 congenic BALB.NK mice-a novel thymic subset defined in BALB.NK mice. Stenström M, et al. Immunology, 2005 Mar. PMID 15720435, Free PMC Article
  2. Identification of a cell-surface antigen selectively expressed on the natural killer cell. Glimcher L, et al. J Exp Med, 1977 Jan 1. PMID 187714, Free PMC Article
  3. Genetic variation in antibody response and natural killer cell activity against a Moloney virus-induced lymphoma (YAC). Asjö B, et al. Eur J Immunol, 1977 Aug. PMID 902682
  4. Pan natural killer cell monoclonal antibodies and their relationship to the NK1.1 antigen. Sentman CL, et al. Hybridoma, 1989 Dec. PMID 2613267
  5. The genetic regulation of NK-activity: studies on congenic mice with B10 or AKR background. Klein GO, et al. J Immunogenet, 1980 Oct. PMID 7430679

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling.
    Title: Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling.
  2. Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1(+) cell activation in mice.
    Title: Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1(+) cell activation in mice.
  3. data showed that both Nkrp1b protein variants form monomers and homodimers irrespective of the presence of the stalk.
    Title: The C-type lectin-like receptor Nkrp1b: Structural proteomics reveals features affecting protein conformation and interactions.
  4. Data suggest that expression of killer cell lectin-like receptor subfamily B member 1C protein (NK1.1) defines a population of rapidly expanding effector CD4(+) T cells that specifically promote plasmablast induction during Plasmodium infection.
    Title: NK1.1 Expression Defines a Population of CD4(+) Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection.
  5. Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface.
    Title: Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.
  6. The adoptive transfer of NK1.1(-) CD4(+) NKG2D(+) cells suppressed DSS-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics.
    Title: NK1.1(-) CD4(+) NKG2D(+) T cells suppress DSS-induced colitis in mice through production of TGF-β.
  7. MCMV may encode a novel Clr-b-independent immunoevasin that functionally engages the NKR-P1B receptor.
    Title: Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.
  8. NK1.1+ CD8+ T cells have a role in TGF-beta control and contribute to early microbial pathogen response
    Title: NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response.
  9. Data indicate that C-type lectin-like NK receptor NKR-P1C proteins showed no affinity to the various neoglycoproteins.
    Title: Re-evaluation of the involvement of NK cells and C-type lectin-like NK receptors in modulation of immune responses by multivalent GlcNAc-terminated oligosaccharides.
  10. 5-HT3 and NK1 immunopositive macrophages and mucosal mast cells in lamina propria release 5-HT and substance P, which in turn activate their corresponding receptors on mucosal cells in autocrine and paracrine manners.
    Title: Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Not Applicable (2)  1 citation
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within natural killer cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
killer cell lectin-like receptor subfamily B member 1C
Names
CD161 antigen-like family member C
NKR-P1 40
NKR-P1B
killer cell lectin-like receptor subfamily A member 1C
lymphocyte antigen 55 complex, locus C
lymphocyte antigen 55c
lymphocyte antigen 59
natural killer cell receptor protein NKR-P1C
natural killer cell receptor-P1
natural killer cell surface protein P1-40
natural killer cell-associated antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159904.2 → NP_001153376.2  killer cell lectin-like receptor subfamily B member 1C isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102693
    Consensus CDS
    CCDS51919.1
    UniProtKB/Swiss-Prot
    P27814, Q541U5, Q925G3
    UniProtKB/TrEMBL
    A0A1U9W192
    Related
    ENSMUSP00000134504.3, ENSMUST00000174404.8
    Conserved Domains (1) summary
    cd03593
    Location:94 → 212
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. NM_008527.3 → NP_032553.3  killer cell lectin-like receptor subfamily B member 1C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC102693
    Consensus CDS
    CCDS39654.2
    UniProtKB/TrEMBL
    A0A1U9W195
    Related
    ENSMUSP00000127297.4, ENSMUST00000167691.9
    Conserved Domains (1) summary
    cd03593
    Location:91 → 209
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128755448..128765514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27814.2 GenPept UniProtKB/Swiss-Prot:P27814

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