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Nxf7 nuclear RNA export factor 7 [ Mus musculus (house mouse) ]

Gene ID: 170722, updated on 28-Oct-2024

Summary

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Official Symbol
Nxf7provided by MGI
Official Full Name
nuclear RNA export factor 7provided by MGI
Primary source
MGI:MGI:2159343
See related
Ensembl:ENSMUSG00000031410 AllianceGenome:MGI:2159343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nx7; Nxf6; nxf-a; nfx-a1; nxf-a2
Summary
Enables mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in cytoplasm. Is expressed in central nervous system; extraembryonic component; sensory organ; and testis. Orthologous to human NXF2 (nuclear RNA export factor 2) and NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward placenta adult (RPKM 40.5) See more
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Genomic context

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See Nxf7 in Genome Data Viewer
Location:
X F1; X 57.25 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134480304..134499530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135579555..135598781, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 22233 Neighboring gene preferentially expressed antigen in melanoma-like 3 pseudogene Neighboring gene PRAME like, X-linked 1 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene t-complex 11 family, X-linked 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice. Callaerts-Vegh Z, et al. Front Behav Neurosci, 2015. PMID 26217206, Free PMC Article
  2. Nuclear RNA export factor 7 is localized in processing bodies and neuronal RNA granules through interactions with shuttling hnRNPs. Katahira J, et al. Nucleic Acids Res, 2008 Feb. PMID 18063567, Free PMC Article
  3. Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene. Esposito T, et al. Hum Mol Genet, 2013 Sep 15. PMID 23686279
  4. Identification and characterization of the mouse nuclear export factor (Nxf) family members. Tan W, et al. Nucleic Acids Res, 2005. PMID 16027110, Free PMC Article
  5. Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability. Vanmarsenille L, et al. PLoS One, 2013. PMID 23675524, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that NXF7 plays a role in sorting, transport and/or storage of mRNAs through interactions with hnRNP A3.
    Title: Nuclear RNA export factor 7 is localized in processing bodies and neuronal RNA granules through interactions with shuttling hnRNPs.
  2. NXF7 colocalizes with Staufen1, polyA, and 28 S RNA within mobile cytoplasmic granules in neurites and in extended cytoplasmic processes of non-neuronal cells
    Title: Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.
  3. NXF7 localizes exclusively to cytoplasmic granules and lacks mRNA export activity.
    Title: Identification and characterization of the mouse nuclear export factor (Nxf) family members.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear RNA export factor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear RNA export factor 7
Names
nuclear RNA export factor 6
nuclear export factor a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379677.1 → NP_001366606.1  nuclear RNA export factor 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671911
    UniProtKB/TrEMBL
    Q99JG5
    Conserved Domains (6) summary
    smart00804
    Location:548 → 609
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:217 → 259
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:110 → 191
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:258 → 320
    LRR_8; Leucine rich repeat
    cd21340
    Location:224 → 364
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl09109
    Location:383 → 529
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

  2. NM_130888.2 → NP_570958.1  nuclear RNA export factor 7 isoform 1

    See identical proteins and their annotated locations for NP_570958.1

    Status: VALIDATED

    Source sequence(s)
    AL671911
    Consensus CDS
    CCDS30406.1
    UniProtKB/TrEMBL
    Q80SZ6, Q99JG5
    Related
    ENSMUSP00000108788.2, ENSMUST00000113163.8
    Conserved Domains (5) summary
    smart00804
    Location:558 → 619
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:227 → 269
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam13855
    Location:269 → 330
    LRR_8; Leucine rich repeat
    pfam09162
    Location:119 → 201
    Tap-RNA_bind; Tap, RNA-binding
    cl09109
    Location:393 → 539
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    134480304..134499530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528509.3 → XP_006528572.1  nuclear RNA export factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006528572.1

    UniProtKB/TrEMBL
    Q80SZ6, Q99JG5
    Conserved Domains (5) summary
    smart00804
    Location:558 → 619
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:227 → 269
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam13855
    Location:269 → 330
    LRR_8; Leucine rich repeat
    pfam09162
    Location:119 → 201
    Tap-RNA_bind; Tap, RNA-binding
    cl09109
    Location:393 → 539
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

  2. XM_006528511.4 → XP_006528574.1  nuclear RNA export factor 7 isoform X2

    See identical proteins and their annotated locations for XP_006528574.1

    UniProtKB/TrEMBL
    Q99JG5
    Conserved Domains (6) summary
    smart00804
    Location:548 → 609
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:217 → 259
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:110 → 191
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:258 → 320
    LRR_8; Leucine rich repeat
    cd21340
    Location:224 → 364
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl09109
    Location:383 → 529
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
Nucleotide Protein Strain
Heading Accession and Version

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