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Kcnh7 potassium voltage-gated channel subfamily H member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170739, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnh7provided by RGD
Official Full Name
potassium voltage-gated channel subfamily H member 7provided by RGD
Primary source
RGD:621112
See related
EnsemblRapid:ENSRNOG00000007528 AllianceGenome:RGD:621112
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
erg3
Summary
Enables inward rectifier potassium channel activity. Involved in circadian rhythm and potassium ion transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH7 (potassium voltage-gated channel subfamily H member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 126.3), Kidney (RPKM 7.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Kcnh7 in Genome Data Viewer
Location:
3q21
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (67737900..68230950, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (47329338..47822122, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (48662450..49168716, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SHOC2 leucine-rich repeat scaffold protein, pseudogene 1 Neighboring gene interferon induced with helicase C domain 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene grancalcin Neighboring gene uncharacterized LOC108350383 Neighboring gene uncharacterized LOC134486366

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator. Perry M, et al. Mol Pharmacol, 2008 Apr. PMID 18162604, Free PMC Article
  2. Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell. Mühlbauer E, et al. Cell Mol Life Sci, 2007 Mar. PMID 17322986, Free PMC Article
  3. Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence for a multigene family. Long RM, et al. Biochem Biophys Res Commun, 1988 Oct 31. PMID 2973315
  4. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, et al. J Physiol, 2005 Apr 1. PMID 15677682, Free PMC Article
  5. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, et al. Pflugers Arch, 2001 Jan. PMID 11212207

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The differential sensitivity of hERG1 and rERG3 channels to the agonist effect of RPR could be accounted for by a single S5 residue (Thr556 in hERG1, Ile558 in rERG3).
    Title: A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
voltage-gated inwardly rectifying potassium channel KCNH7; potassium voltage-gated channel subfamily H member 7
Names
ERG-3
eag-related protein 3
ether-a-go-go-related gene potassium channel 3
ether-a-go-go-related protein 3
potassium channel erg3
potassium channel, voltage gated eag related subfamily H, member 7
potassium voltage-gated channel, subfamily H (eag-related), member 7
voltage-gated potassium channel subunit Kv11.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131912.1 → NP_571987.1  voltage-gated inwardly rectifying potassium channel KCNH7

    See identical proteins and their annotated locations for NP_571987.1

    Status: PROVISIONAL

    Source sequence(s)
    AF016191
    UniProtKB/Swiss-Prot
    O54852
    UniProtKB/TrEMBL
    A0A8I5ZLI3, A6HLW2
    Related
    ENSRNOP00000078968.2, ENSRNOT00000119314.2
    Conserved Domains (6) summary
    COG0664
    Location:739 → 869
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:745 → 856
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 130
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:448 → 671
    Ion_trans; Ion transport protein
    pfam07885
    Location:614 → 668
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    67737900..68230950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283033.1 → XP_063139103.1  potassium voltage-gated channel subfamily H member 7 isoform X4

    Related
    ENSRNOP00000078922.2, ENSRNOT00000112058.2

  2. XM_063283031.1 → XP_063139101.1  potassium voltage-gated channel subfamily H member 7 isoform X3

    Related
    ENSRNOP00000072574.3, ENSRNOT00000085246.3

  3. XM_017591438.3 → XP_017446927.1  potassium voltage-gated channel subfamily H member 7 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHF2

  4. XM_006234269.5 → XP_006234331.1  potassium voltage-gated channel subfamily H member 7 isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHF2
    Related
    ENSRNOP00000009920.6, ENSRNOT00000009920.6
    Conserved Domains (6) summary
    COG0664
    Location:747 → 877
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:753 → 864
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 130
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:456 → 679
    Ion_trans; Ion transport protein
    pfam07885
    Location:622 → 676
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54852.1 GenPept UniProtKB/Swiss-Prot:O54852

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