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Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [ Mus musculus (house mouse) ]

Gene ID: 170750, updated on 2-Nov-2024

Summary

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Official Symbol
Xpnpep1provided by MGI
Official Full Name
X-prolyl aminopeptidase (aminopeptidase P) 1, solubleprovided by MGI
Primary source
MGI:MGI:2180003
See related
Ensembl:ENSMUSG00000025027 AllianceGenome:MGI:2180003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sAMP; D230045I08Rik
Summary
Predicted to enable manganese ion binding activity; metalloaminopeptidase activity; and protein homodimerization activity. Predicted to be involved in bradykinin catabolic process; negative regulation of programmed cell death; and proteolysis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 157.6), small intestine adult (RPKM 86.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Xpnpep1 in Genome Data Viewer
Location:
19 D2; 19 46.91 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (52919710..53027093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (52931279..53038662, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41860 Neighboring gene STARR-seq mESC enhancer starr_46416 Neighboring gene STARR-seq mESC enhancer starr_46417 Neighboring gene STARR-seq mESC enhancer starr_46418 Neighboring gene STARR-seq mESC enhancer starr_46419 Neighboring gene STARR-seq mESC enhancer starr_46420 Neighboring gene expressed sequence AA387883 Neighboring gene predicted gene, 41861 Neighboring gene STARR-positive B cell enhancer ABC_E7671 Neighboring gene STARR-seq mESC enhancer starr_46426 Neighboring gene STARR-seq mESC enhancer starr_46431 Neighboring gene microRNA 6407 Neighboring gene STARR-seq mESC enhancer starr_46433 Neighboring gene RIKEN cDNA 1700054A03 gene Neighboring gene predicted gene, 54048 Neighboring gene predicted gene, 30234

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency. Yoon SH, et al. Sci Rep, 2021 Jan 13. PMID 33441619, Free PMC Article
  2. Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1. Yoon SH, et al. Biochem Biophys Res Commun, 2012 Dec 14. PMID 23131567
  3. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Clee SM, et al. Nat Genet, 2006 Jun. PMID 16682971
  4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency.
    Title: Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency.
  2. These results suggest an essential role for APP1-mediated peptide metabolism in body and brain development, and indicate a strong causal link between APP1 deficiency and peptiduria.
    Title: Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables aminopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metalloaminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloaminopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bradykinin catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of programmed cell death ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
xaa-Pro aminopeptidase 1
Names
X-Pro aminopeptidase 1
aminoacylproline aminopeptidase
cytosolic aminopeptidase P
NP_001361763.1
NP_573479.3
XP_011245460.1
XP_011245461.1
XP_017173564.1
XP_030106621.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374834.1 → NP_001361763.1  xaa-Pro aminopeptidase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163221
    Consensus CDS
    CCDS89415.1
    UniProtKB/Swiss-Prot
    Q6P1B1, Q91Y37
    UniProtKB/TrEMBL
    Q3TL27, Q3UKF5
    Conserved Domains (4) summary
    cd01085
    Location:329 → 551
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:557 → 618
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:157 → 326
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:10 → 154
    Creatinase_N; Creatinase/Prolidase N-terminal domain

  2. NM_133216.4 → NP_573479.3  xaa-Pro aminopeptidase 1 isoform 1

    See identical proteins and their annotated locations for NP_573479.3

    Status: VALIDATED

    Source sequence(s)
    AC163221
    Consensus CDS
    CCDS29899.2
    UniProtKB/TrEMBL
    Q3UE92, S4R1I3
    Related
    ENSMUSP00000138250.2, ENSMUST00000183108.8
    Conserved Domains (4) summary
    cd01085
    Location:372 → 594
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:600 → 661
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:200 → 369
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:53 → 197
    Creatinase_N; Creatinase/Prolidase N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    52919710..53027093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247158.3 → XP_011245460.1  xaa-Pro aminopeptidase 1 isoform X1

    UniProtKB/TrEMBL
    S4R1I3
    Conserved Domains (4) summary
    cd01085
    Location:372 → 594
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:600 → 624
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:200 → 369
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:53 → 197
    Creatinase_N; Creatinase/Prolidase N-terminal domain

  2. XM_030250761.2 → XP_030106621.1  xaa-Pro aminopeptidase 1 isoform X3

    UniProtKB/TrEMBL
    A0A494BBG8, Q3TL27
    Related
    ENSMUSP00000158501.2, ENSMUST00000236008.2
    Conserved Domains (4) summary
    cd01085
    Location:329 → 551
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:557 → 581
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:157 → 326
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:10 → 154
    Creatinase_N; Creatinase/Prolidase N-terminal domain

  3. XM_011247159.2 → XP_011245461.1  xaa-Pro aminopeptidase 1 isoform X2

    See identical proteins and their annotated locations for XP_011245461.1

    UniProtKB/Swiss-Prot
    Q6P1B1, Q91Y37
    UniProtKB/TrEMBL
    Q3TL27, Q3UKF5
    Related
    ENSMUSP00000158390.2, ENSMUST00000237294.2
    Conserved Domains (4) summary
    cd01085
    Location:329 → 551
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:557 → 618
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:157 → 326
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:10 → 154
    Creatinase_N; Creatinase/Prolidase N-terminal domain

  4. XM_017318075.3 → XP_017173564.1  xaa-Pro aminopeptidase 1 isoform X4

    UniProtKB/TrEMBL
    Q3TL27
    Related
    ENSMUST00000182877.8
    Conserved Domains (3) summary
    cd01085
    Location:258 → 480
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:486 → 547
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:86 → 255
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1B1.1 GenPept UniProtKB/Swiss-Prot:Q6P1B1

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