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Hook2 hook microtubule tethering protein 2 [ Mus musculus (house mouse) ]

Gene ID: 170833, updated on 28-Oct-2024

Summary

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Official Symbol
Hook2provided by MGI
Official Full Name
hook microtubule tethering protein 2provided by MGI
Primary source
MGI:MGI:2181664
See related
Ensembl:ENSMUSG00000052566 AllianceGenome:MGI:2181664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mHK2; A630054I03Rik
Summary
Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be located in cytosol and trans-Golgi network. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Orthologous to human HOOK2 (hook microtubule tethering protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 21.0), testis adult (RPKM 20.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Hook2 in Genome Data Viewer
Location:
8 C3; 8 41.44 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85715402..85729981)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84988776..85003352)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 2 Neighboring gene STARR-seq mESC enhancer starr_22143 Neighboring gene STARR-positive B cell enhancer ABC_E1764 Neighboring gene STARR-positive B cell enhancer ABC_E706 Neighboring gene jun B proto-oncogene Neighboring gene STARR-positive B cell enhancer ABC_E5029 Neighboring gene STARR-positive B cell enhancer ABC_E3789 Neighboring gene bestrophin 2 Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome. Moynihan KL, et al. Mol Biol Cell, 2009 Nov. PMID 19793914, Free PMC Article
  2. LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility. Liu Y, et al. PLoS Genet, 2015 Mar. PMID 25781171, Free PMC Article
  3. Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). White RA, et al. Blood Cells Mol Dis, 2009 Sep-Oct. PMID 19409822
  4. Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Quesnel-Vallières M, et al. Genes Dev, 2015 Apr 1. PMID 25838543, Free PMC Article
  5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28586, MGC91008

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton-dependent intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in early endosome to late endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
  
part_of FHF complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of HOPS complex IEA
Inferred from Electronic Annotation
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein Hook homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167991.3 → NP_001161463.1  protein Hook homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001161463.1

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q3TKK8, Q3UWV9
    Conserved Domains (2) summary
    pfam05622
    Location:8 → 703
    HOOK; HOOK protein
    pfam10267
    Location:260 → 344
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  2. NM_001363497.2 → NP_001350426.1  protein Hook homolog 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:8 → 707
    HOOK; HOOK protein

  3. NM_001363498.2 → NP_001350427.1  protein Hook homolog 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163703
    Consensus CDS
    CCDS90430.1
    UniProtKB/TrEMBL
    A0A1B0GT78, Q3UWV9
    Related
    ENSMUSP00000148237.2, ENSMUST00000209764.2
    Conserved Domains (1) summary
    pfam05622
    Location:8 → 680
    HOOK; HOOK protein

  4. NM_001372357.1 → NP_001359286.1  protein Hook homolog 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:8 → 770
    HOOK; HOOK protein

  5. NM_001372358.1 → NP_001359287.1  protein Hook homolog 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:8 → 701
    HOOK; HOOK protein

  6. NM_001372359.1 → NP_001359288.1  protein Hook homolog 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:8 → 700
    HOOK; HOOK protein

  7. NM_001372360.1 → NP_001359289.1  protein Hook homolog 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:8 → 691
    HOOK; HOOK protein

  8. NM_001372361.1 → NP_001359290.1  protein Hook homolog 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:60 → 634
    HOOK; HOOK protein

  9. NM_001372362.1 → NP_001359291.1  protein Hook homolog 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC163703
    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:1 → 569
    HOOK; HOOK protein

  10. NM_133255.4 → NP_573518.2  protein Hook homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_573518.2

    Status: VALIDATED

    Source sequence(s)
    AC163703
    Consensus CDS
    CCDS22489.1
    UniProtKB/Swiss-Prot
    Q66JV2, Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2
    UniProtKB/TrEMBL
    Q3UWV9
    Related
    ENSMUSP00000067752.7, ENSMUST00000064495.8
    Conserved Domains (2) summary
    pfam05622
    Location:8 → 704
    HOOK; HOOK protein
    pfam10267
    Location:260 → 344
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

RNA

  1. NR_156707.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163703

  2. NR_164168.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163703

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85715402..85729981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243323.2 → XP_030099183.1  protein Hook homolog 2 isoform X6

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:1 → 635
    HOOK; HOOK protein

  2. XM_030243325.2 → XP_030099185.1  protein Hook homolog 2 isoform X6

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:1 → 635
    HOOK; HOOK protein

  3. XM_036153782.1 → XP_036009675.1  protein Hook homolog 2 isoform X5

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (2) summary
    pfam05622
    Location:66 → 655
    HOOK; HOOK protein
    pfam19047
    Location:16 → 44
    HOOK_N; HOOK domain

  4. XM_036153778.1 → XP_036009671.1  protein Hook homolog 2 isoform X1

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (2) summary
    pfam05622
    Location:179 → 767
    HOOK; HOOK protein
    pfam19047
    Location:7 → 157
    HOOK_N; HOOK domain

  5. XM_036153780.1 → XP_036009673.1  protein Hook homolog 2 isoform X3

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (2) summary
    pfam05622
    Location:179 → 704
    HOOK; HOOK protein
    cl41774
    Location:7 → 156
    HkD_SF; Hook domain-containing proteins superfamily

  6. XM_036153781.1 → XP_036009674.1  protein Hook homolog 2 isoform X4

    Conserved Domains (2) summary
    pfam05622
    Location:110 → 699
    HOOK; HOOK protein
    pfam19047
    Location:60 → 88
    HOOK_N; HOOK domain

  7. XM_036153779.1 → XP_036009672.1  protein Hook homolog 2 isoform X2

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (2) summary
    pfam05622
    Location:230 → 819
    HOOK; HOOK protein
    pfam19047
    Location:67 → 208
    HOOK_N; HOOK domain

  8. XM_030243326.2 → XP_030099186.1  protein Hook homolog 2 isoform X6

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:1 → 635
    HOOK; HOOK protein

  9. XM_030243322.1 → XP_030099182.1  protein Hook homolog 2 isoform X6

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:1 → 635
    HOOK; HOOK protein

  10. XM_030243324.1 → XP_030099184.1  protein Hook homolog 2 isoform X6

    UniProtKB/TrEMBL
    Q3UWV9
    Conserved Domains (1) summary
    pfam05622
    Location:1 → 635
    HOOK; HOOK protein

  11. XM_030243328.2 → XP_030099188.1  protein Hook homolog 2 isoform X7

    Conserved Domains (1) summary
    pfam05622
    Location:1 → 390
    HOOK; HOOK protein

RNA

  1. XR_004934775.1 RNA Sequence

  2. XR_004934776.1 RNA Sequence

  3. XR_004934778.1 RNA Sequence

  4. XR_004934773.1 RNA Sequence

  5. XR_004934774.1 RNA Sequence

  6. XR_004934777.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMK6.3 GenPept UniProtKB/Swiss-Prot:Q7TMK6

Gene LinkOut

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