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Map2k1 mitogen activated protein kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170851, updated on 2-Nov-2024

Summary

Official Symbol
Map2k1provided by RGD
Official Full Name
mitogen activated protein kinase kinase 1provided by RGD
Primary source
RGD:70495
See related
EnsemblRapid:ENSRNOG00000010176 AllianceGenome:RGD:70495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mek1
Summary
Enables ATP binding activity; MAP kinase kinase activity; and enzyme binding activity. Involved in several processes, including regulation of gene expression; regulation of intracellular signal transduction; and regulation of muscle contraction. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 508.0), Muscle (RPKM 301.3) and 9 other tissues See more
Orthologs
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Genomic context

See Map2k1 in Genome Data Viewer
Location:
8q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (73578747..73650184, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64683449..64754900, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (69134218..69722573, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 18C Neighboring gene ribosomal protein L4 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene uncharacterized LOC134480193 Neighboring gene transfer RNA serine (anticodon AGA) 48 Neighboring gene timeless interacting protein Neighboring gene small Cajal body-specific RNA 14

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables MAP-kinase scaffold activity IEA
Inferred from Electronic Annotation
more info
 
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Bergmann glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Bergmann glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in ERBB2-ERBB3 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in ERBB2-ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi inheritance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in Schwann cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in Schwann cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellar cortex formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebellar cortex formation ISO
Inferred from Sequence Orthology
more info
 
involved_in endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell proliferation involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in face development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within face development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in labyrinthine layer development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within labyrinthine layer development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in melanosome transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of homotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in placenta blood vessel development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within placenta blood vessel development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Golgi inheritance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thymus development ISO
Inferred from Sequence Orthology
more info
 
involved_in thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in trachea formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within trachea formation ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle transport along microtubule IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 1
Names
ERK activator kinase 1
MAP kinase kinase 1
MAP kinase/Erk kinase 1
MAPK/ERK kinase 1
MAPKK 1
NP_113831.1
XP_038936667.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031643.4NP_113831.1  dual specificity mitogen-activated protein kinase kinase 1

    See identical proteins and their annotated locations for NP_113831.1

    Status: VALIDATED

    Source sequence(s)
    AI603089, BC089772
    UniProtKB/Swiss-Prot
    Q01986, Q5EBD5
    UniProtKB/TrEMBL
    A0A0H2UHI2, A6J5B8
    Related
    ENSRNOP00000084527.2, ENSRNOT00000120242.2
    Conserved Domains (1) summary
    cd06650
    Location:62380
    PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    73578747..73650184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080739.2XP_038936667.1  dual specificity mitogen-activated protein kinase kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZT77, A0A8I6A1J3
    Related
    ENSRNOP00000086602.1, ENSRNOT00000102833.2
    Conserved Domains (1) summary
    cd06650
    Location:40358
    PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1