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Erg ETS transcription factor ERG [ Rattus norvegicus (Norway rat) ]

Gene ID: 170909, updated on 6-Jun-2024

Summary

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Official Symbol
Ergprovided by RGD
Official Full Name
ETS transcription factor ERGprovided by RGD
Primary source
RGD:621108
See related
Ensembl:ENSRNOG00000001652 AllianceGenome:RGD:621108
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell migration; mesenchyme development; and positive regulation of blood vessel remodeling. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 124.0), Heart (RPKM 53.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Erg in Genome Data Viewer
Location:
11q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48148149..48370472, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (34678614..34900951, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (35645317..35749637, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095565 Neighboring gene uncharacterized LOC102550135 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 15 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120095640 Neighboring gene ETS proto-oncogene 2, transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines. Nhili R, et al. Nucleic Acids Res, 2013 Jan 7. PMID 23093599, Free PMC Article
  2. Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder. Birger Y, et al. Blood, 2013 Aug 8. PMID 23719302, Free PMC Article
  3. ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. Yuan L, et al. J Biol Chem, 2012 Feb 24. PMID 22235125, Free PMC Article
  4. Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Birdsey GM, et al. Blood, 2008 Apr 1. PMID 18195090, Free PMC Article
  5. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, et al. Am J Respir Cell Mol Biol, 2020 Jul. PMID 32209028

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcriptional regulator ERG
Names
ERG, ETS transcription factor
avian erythroblastosis virus E-26 (v-ets) oncogene related
v-ets avian erythroblastosis virus E26 oncogene
v-ets erythroblastosis virus E26 oncogene homolog
v-ets erythroblastosis virus E26 oncogene like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133397.2 → NP_596888.1  transcriptional regulator ERG

    See identical proteins and their annotated locations for NP_596888.1

    Status: PROVISIONAL

    Source sequence(s)
    AB031088
    UniProtKB/TrEMBL
    Q6IMZ7, Q91XV5
    Conserved Domains (2) summary
    smart00413
    Location:286 → 369
    ETS; erythroblast transformation specific domain
    cl15755
    Location:115 → 198
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    48148149..48370472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087928.1 → XP_038943856.1  transcriptional regulator ERG isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMT0, A6KPU4, Q6IMZ7
    Conserved Domains (2) summary
    smart00413
    Location:317 → 400
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_039087933.1 → XP_038943861.1  transcriptional regulator ERG isoform X7

    UniProtKB/TrEMBL
    A0A8I6A9N1, Q6IMZ7
    Related
    ENSRNOP00000090227.1, ENSRNOT00000119400.1
    Conserved Domains (2) summary
    smart00413
    Location:270 → 353
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  3. XM_039087931.1 → XP_038943859.1  transcriptional regulator ERG isoform X4

    UniProtKB/TrEMBL
    A6KPU6, D4A3D6, Q6IMZ7
    Related
    ENSRNOP00000047414.6, ENSRNOT00000039999.6
    Conserved Domains (2) summary
    smart00413
    Location:293 → 376
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  4. XM_063270253.1 → XP_063126323.1  transcriptional regulator ERG isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZKZ6, A6KPU5, Q6IMZ7

  5. XM_039087929.2 → XP_038943857.1  transcriptional regulator ERG isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMT0, A6KPU4, Q6IMZ7
    Related
    ENSRNOP00000079399.1
    Conserved Domains (2) summary
    smart00413
    Location:317 → 400
    ETS; erythroblast transformation specific domain
    cl15755
    Location:122 → 205
    SAM_superfamily; SAM (Sterile alpha motif )

  6. XM_006248142.5 → XP_006248204.1  transcriptional regulator ERG isoform X2

    See identical proteins and their annotated locations for XP_006248204.1

    UniProtKB/TrEMBL
    A0A0G2JWE9, A6KPU7, Q6IMZ7
    Related
    ENSRNOP00000069853.1
    Conserved Domains (2) summary
    smart00413
    Location:310 → 393
    ETS; erythroblast transformation specific domain
    cl15755
    Location:115 → 198
    SAM_superfamily; SAM (Sterile alpha motif )

  7. XM_063270256.1 → XP_063126326.1  transcriptional regulator ERG isoform X8

    UniProtKB/TrEMBL
    Q6IMZ7

  8. XM_063270254.1 → XP_063126324.1  transcriptional regulator ERG isoform X5

    UniProtKB/TrEMBL
    Q6IMZ7

  9. XM_063270255.1 → XP_063126325.1  transcriptional regulator ERG isoform X6

    UniProtKB/TrEMBL
    A0A0G2JYF1

  10. XM_039087932.2 → XP_038943860.1  transcriptional regulator ERG isoform X6

    UniProtKB/TrEMBL
    A0A0G2JYF1
    Conserved Domains (2) summary
    smart00413
    Location:278 → 361
    ETS; erythroblast transformation specific domain
    cl15755
    Location:83 → 166
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein Strain
Heading Accession and Version

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