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Klc1 kinesin light chain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171041, updated on 10-Oct-2024

Summary

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Official Symbol
Klc1provided by RGD
Official Full Name
kinesin light chain 1provided by RGD
Primary source
RGD:621411
See related
EnsemblRapid:ENSRNOG00000011572 AllianceGenome:RGD:621411
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kns2
Summary
Enables tubulin binding activity. Involved in intracellular protein transport and protein localization to synapse. Located in several cellular components, including growth cone; neuronal cell body; and vesicle. Part of kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Orthologous to human KLC1 (kinesin light chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 438.1), Muscle (RPKM 135.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klc1 in Genome Data Viewer
Location:
6q32
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136644592..136690399)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130823416..130866729)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136330151..136373716)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene BAG cochaperone 5 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene uncharacterized LOC134479261 Neighboring gene X-ray repair cross complementing 3 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene UPF0235 protein C15orf40 homolog Neighboring gene atherin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease. Traina G, et al. Neurochem Int, 2008 Dec. PMID 18761385
  2. Vaccinia virus A36R membrane protein provides a direct link between intracellular enveloped virions and the microtubule motor kinesin. Ward BM, et al. J Virol, 2004 Mar. PMID 14963148, Free PMC Article
  3. Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing. Cyr JL, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946431, Free PMC Article
  4. Kinesin light chain 1 gene haplotypes in three conformational diseases. von Otter M, et al. Neuromolecular Med, 2010 Sep. PMID 19911314
  5. Tubulin tyrosination navigates the kinesin-1 motor domain to axons. Konishi Y, et al. Nat Neurosci, 2009 May. PMID 19377471

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Consistently, inhibition of tubulin tyrosination in rat hippocampal neurons resulted in the distribution of truncated kinesin-1 in both axons and dendrites.
    Title: Tubulin tyrosination navigates the kinesin-1 motor domain to axons.
  2. We observed that acetyl-l-carnitine increases the light-chain subunit of kinesin-1 gene expression.The fast anterograde axonal transport of amyloid-beta peptide is mediated by direct binding to the light-chain subunit of kinesin-1.
    Title: Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease.
  3. For Kinesin-1, activation requires a global conformational change that separates the kinesin heavy chain (KHC) motor and tail domains and a local conformational change that moves the KHC motor domains closer together.
    Title: Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells.
  4. Binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for microtubule binding and motility.
    Title: Two binding partners cooperate to activate the molecular motor Kinesin-1.
  5. Kidins220/ARMS-positive carriers undergo a kinesin-1-dependent transport linked to neurotrophin action.
    Title: Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation.
  6. the intermediate chain of dynein binds to kinesin light chains 1 and 2. The interaction is both direct and specific
    Title: A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity.
  7. Calsyntenin-1 links a certain type of vesicular and tubulovesicular organelles to the Kinesin-1 motor.
    Title: Calsyntenin-1 docks vesicular cargo to kinesin-1.
  8. Together, these results indicate that DISC1 regulates the localization of NUDEL/LIS1/14-3-3epsilon complex into the axons as a cargo receptor for axon elongation.
    Title: DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.
  9. wild-type torsinA undergoes anterograde transport along microtubules mediated by kinesin and may act as a molecular chaperone regulating kinesin activity and/or cargo binding
    Title: The early onset dystonia protein torsinA interacts with kinesin light chain 1.
  10. These results indicate that the CRMP-2/Kinesin-1 complex regulates soluble tubulin transport to the distal part of the growing axon.
    Title: Tubulin and CRMP-2 complex is transported via Kinesin-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axo-dendritic transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress granule disassembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary rootlet ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin light chain 1
Names
KLC 1
kinesin 2
NP_001075441.1
NP_001075442.1
NP_001075443.1
XP_006240683.1
XP_006240684.1
XP_006240685.1
XP_006240689.1
XP_006240690.1
XP_006240691.1
XP_006240692.1
XP_038967663.1
XP_038967665.1
XP_038967667.1
XP_038967668.1
XP_038967669.1
XP_063117578.1
XP_063117579.1
XP_063117580.1
XP_063117581.1
XP_063117582.1
XP_063117583.1
XP_063117584.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081972.1 → NP_001075441.1  kinesin light chain 1 isoform A

    Status: PROVISIONAL

    Source sequence(s)
    M75146
    UniProtKB/TrEMBL
    A0A8L2RC24
    Related
    ENSRNOP00000079658.2, ENSRNOT00000118156.2
    Conserved Domains (3) summary
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296 → 337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:293 → 370
    TPR_12; Tetratricopeptide repeat

  2. NM_001081973.1 → NP_001075442.1  kinesin light chain 1 isoform B

    Status: PROVISIONAL

    Source sequence(s)
    M75147
    UniProtKB/TrEMBL
    A0A8L2RC24
    Related
    ENSRNOP00000075931.2, ENSRNOT00000092774.3
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  3. NM_001081974.1 → NP_001075443.1  kinesin light chain 1 isoform C

    See identical proteins and their annotated locations for NP_001075443.1

    Status: PROVISIONAL

    Source sequence(s)
    M75148
    UniProtKB/Swiss-Prot
    P37285
    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    136644592..136690399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261508.1 → XP_063117578.1  kinesin light chain 1 isoform X1

  2. XM_063261512.1 → XP_063117582.1  kinesin light chain 1 isoform X9

    Related
    ENSRNOP00000081868.2, ENSRNOT00000119218.2

  3. XM_063261510.1 → XP_063117580.1  kinesin light chain 1 isoform X4

  4. XM_063261513.1 → XP_063117583.1  kinesin light chain 1 isoform X11

  5. XM_063261509.1 → XP_063117579.1  kinesin light chain 1 isoform X3

  6. XM_063261511.1 → XP_063117581.1  kinesin light chain 1 isoform X7

  7. XM_006240621.5 → XP_006240683.1  kinesin light chain 1 isoform X2

    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296 → 337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:293 → 370
    TPR_12; Tetratricopeptide repeat

  8. XM_006240623.5 → XP_006240685.1  kinesin light chain 1 isoform X6

    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296 → 337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:293 → 370
    TPR_12; Tetratricopeptide repeat

  9. XM_006240627.5 → XP_006240689.1  kinesin light chain 1 isoform X11

    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  10. XM_006240622.5 → XP_006240684.1  kinesin light chain 1 isoform X5

    UniProtKB/TrEMBL
    A0A8L2RC24
    Related
    ENSRNOP00000015935.9, ENSRNOT00000015935.10
    Conserved Domains (3) summary
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296 → 337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:293 → 370
    TPR_12; Tetratricopeptide repeat

  11. XM_039111735.2 → XP_038967663.1  kinesin light chain 1 isoform X8

    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  12. XM_039111740.2 → XP_038967668.1  kinesin light chain 1 isoform X15

    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  13. XM_039111737.2 → XP_038967665.1  kinesin light chain 1 isoform X10

    UniProtKB/Swiss-Prot
    P37285
    UniProtKB/TrEMBL
    A0A8L2RC24
    Related
    ENSRNOP00000100318.1, ENSRNOT00000164918.1
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  14. XM_039111739.2 → XP_038967667.1  kinesin light chain 1 isoform X14

    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  15. XM_006240629.5 → XP_006240691.1  kinesin light chain 1 isoform X13

    UniProtKB/TrEMBL
    A0A8L2QTG3, A0A8L2RC24
    Related
    ENSRNOP00000060469.4, ENSRNOT00000065281.6
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  16. XM_006240628.5 → XP_006240690.1  kinesin light chain 1 isoform X12

    UniProtKB/TrEMBL
    A0A140TAB3, A0A8L2RC24
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  17. XM_063261514.1 → XP_063117584.1  kinesin light chain 1 isoform X17

  18. XM_006240630.5 → XP_006240692.1  kinesin light chain 1 isoform X16

    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  19. XM_039111741.2 → XP_038967669.1  kinesin light chain 1 isoform X18

    UniProtKB/TrEMBL
    A0A8L2RC24
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

RNA

  1. XR_010052051.1 RNA Sequence

  2. XR_005505437.2 RNA Sequence

  3. XR_005505438.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37285.2 GenPept UniProtKB/Swiss-Prot:P37285

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