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Folr1 folate receptor alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 171049, updated on 2-Nov-2024

Summary

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Official Symbol
Folr1provided by RGD
Official Full Name
folate receptor alphaprovided by RGD
Primary source
RGD:71032
See related
EnsemblRapid:ENSRNOG00000019902 AllianceGenome:RGD:71032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fbp1
Summary
Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Predicted to be involved in several processes, including circulatory system development; nervous system development; and regulation of signal transduction. Predicted to act upstream of or within folic acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 1929.3) and Testes (RPKM 104.7) See more
Orthologs
human mouse all
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Genomic context

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See Folr1 in Genome Data Viewer
Location:
1q32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165631462..165650430, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156219460..156238436, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166934457..166945864, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene putative uncharacterized protein Neighboring gene folate receptor beta Neighboring gene ribosomal protein L12, pseudogene 3 Neighboring gene anaphase promoting complex subunit 15 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study. Sequeira JM, et al. PLoS One, 2016. PMID 27011008, Free PMC Article
  2. Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome. Pravenec M, et al. Hypertension, 2016 Feb. PMID 26667416
  3. Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule. Birn H, et al. Am J Physiol, 1993 Feb. PMID 8447363
  4. Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules. da Costa M, et al. Am J Physiol Cell Physiol, 2000 Apr. PMID 10751329
  5. Coding sequence, genomic organization and expression of a folate binding protein gene in the rat. Sadasivan E, et al. Gene, 2000 Aug 22. PMID 10974553

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
    Title: A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
  2. Folr1 plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat.
    Title: Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats.
  3. These observations have implications in the pathology of FRa-autoantibodies associated with neural tube defect pregnancy, preterm birth and neurodevelopmental disorders including autism
    Title: Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study.
  4. inherited variation in the expression of Folr1 in the kidney influences the development of the metabolic syndrome
    Title: Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables folic acid receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anterior neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in axon regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to folic acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within folic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in folic acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart looping ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest cell migration involved in heart formation ISO
Inferred from Sequence Orthology
more info
  
involved_in pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
  
involved_in sperm-egg recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
folate receptor alpha
Names
folate binding protein 1
folate receptor 1 (adult)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133527.2 → NP_598211.2  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    FM059473, FM060472, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I6X2, G3V8M6, Q9JL02
    Related
    ENSRNOP00000026962.3, ENSRNOT00000026962.6
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    165631462..165650430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085707.2 → XP_038941635.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    A6I6X2, G3V8M6, Q9JL02
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  2. XM_039085665.2 → XP_038941593.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    A6I6X2, G3V8M6, Q9JL02
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  3. XM_039085757.2 → XP_038941685.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    A6I6X2, G3V8M6, Q9JL02
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  4. XM_063273361.1 → XP_063129431.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    A6I6X2, G3V8M6

  5. XM_063273405.1 → XP_063129475.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    A6I6X2, G3V8M6

  6. XM_017588710.3 → XP_017444199.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    A6I6X2, G3V8M6, Q9JL02
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  7. XM_017588711.3 → XP_017444200.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    A6I6X2, G3V8M6, Q9JL02
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  8. XM_006229842.5 → XP_006229904.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006229904.1

    UniProtKB/TrEMBL
    A6I6X2, G3V8M6, Q9JL02
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  9. XM_063273293.1 → XP_063129363.1  folate receptor alpha isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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