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Il13ra2 interleukin 13 receptor subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171060, updated on 18-Sep-2024

Summary

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Official Symbol
Il13ra2provided by RGD
Official Full Name
interleukin 13 receptor subunit alpha 2provided by RGD
Primary source
RGD:620838
See related
EnsemblRapid:ENSRNOG00000032973 AllianceGenome:RGD:620838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IL-13R-alpha-2
Summary
Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in cellular response to mechanical stimulus. Predicted to be located in extracellular space. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human IL13RA2 (interleukin 13 receptor subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 50.9), Spleen (RPKM 13.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Il13ra2 in Genome Data Viewer
Location:
Xq34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (115814620..115886080, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (111002590..111074053, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (118443955..118514716, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 2C Neighboring gene microRNA 448 Neighboring gene nuclear receptor subfamily 5, group A, member 2, pseudogene 1 Neighboring gene small nucleolar RNA, H/ACA box 35B Neighboring gene leucine rich repeats and calponin homology domain containing 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A3-like Neighboring gene leucine zipper protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interleukin 13 receptors as biochemical markers in atopic patients. Hussein YM, et al. J Investig Allergol Clin Immunol, 2011. PMID 21462799
  2. IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma. Kioi M, et al. Int J Cancer, 2009 Mar 15. PMID 19065664
  3. Molecular cloning of the rat IL-13 alpha 2 receptor cDNA and its expression in rat tissues. Wu AH, et al. J Neurooncol, 2002 Sep. PMID 12241113
  4. In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice. Kawakami K, et al. J Exp Med, 2001 Dec 17. PMID 11748276, Free PMC Article
  5. Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. Aspord C, et al. J Exp Med, 2007 May 14. PMID 17438063, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Ralpha2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
    Title: M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
  2. gene sequence and tissue distribution of IL-13Ralpha2 in the rat
    Title: Molecular cloning of the rat IL-13 alpha 2 receptor cDNA and its expression in rat tissues.
  3. IL13ra2 was upregulated in Il13-mediated minimal-change-like nephropathy.
    Title: Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables cytokine receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immunoglobulin mediated immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-13 receptor subunit alpha-2
Names
IL-13 receptor subunit alpha-2
IL-13R subunit alpha-2
interleukin 13 receptor, alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133538.2 → NP_598222.2  interleukin-13 receptor subunit alpha-2 precursor

    See identical proteins and their annotated locations for NP_598222.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q8VHK6
    UniProtKB/TrEMBL
    A6KGB0, G3V9B6
    Conserved Domains (1) summary
    pfam09240
    Location:138 → 231
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    115814620..115886080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099436.2 → XP_038955364.1  interleukin-13 receptor subunit alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VHK6
    UniProtKB/TrEMBL
    A6KGB0, G3V9B6
    Related
    ENSRNOP00000041564.3, ENSRNOT00000043338.7
    Conserved Domains (1) summary
    pfam09240
    Location:138 → 231
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

  2. XM_006257427.4 → XP_006257489.1  interleukin-13 receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006257489.1

    UniProtKB/Swiss-Prot
    Q8VHK6
    UniProtKB/TrEMBL
    A6KGB0, G3V9B6
    Conserved Domains (1) summary
    pfam09240
    Location:138 → 231
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

  3. XM_063279768.1 → XP_063135838.1  interleukin-13 receptor subunit alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VHK6
    UniProtKB/TrEMBL
    A6KGB0, G3V9B6
    Related
    ENSRNOP00000104947.1, ENSRNOT00000166113.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHK6.1 GenPept UniProtKB/Swiss-Prot:Q8VHK6

Gene LinkOut

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