Atp5mk ATP synthase membrane subunit K [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp5mkprovided by RGD
Official Full Name: ATP synthase membrane subunit Kprovided by RGD
Primary source: RGD:631426
See related: EnsemblRapid:ENSRNOG00000020296 AllianceGenome:RGD:631426
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dapit; Usmg5; Atp5md
Summary: Part of proton-transporting ATP synthase complex. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 6. Orthologous to human ATP5MK (ATP synthase membrane subunit k). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 5327.1), Muscle (RPKM 3715.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (255915255..255922185, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (245973910..245980702, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (266859961..266866753, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

confirm the mitochondrial presence of DAPIT on cellular level. We also show that DAPIT is localized in lysosomes of HUVEC and HEK 293T cells
Title: Cellular and tissue expression of DAPIT, a phylogenetically conserved peptide.
down-regulated in insulin-sensitive tissues (skeletal muscle, myocardium)in streptozotocin-induced diabetes
Title: DAPIT, a novel protein down-regulated in insulin-sensitive tissues in streptozotocin-induced diabetes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137051 (e-PCR)
- UniSTS:219140

RH128718 (e-PCR)
- UniSTS:212026

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP synthase membrane subunit K, mitochondrial

Names: ATP synthase membrane subunit DAPIT, mitochondrial; diabetes-associated protein in insulin-sensitive tissues; up-regulated during skeletal muscle growth 5 homolog; up-regulated during skeletal muscle growth protein 5; upregulated during skeletal muscle growth 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.