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Ptpn21 protein tyrosine phosphatase, non-receptor type 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171070, updated on 17-Aug-2024

Summary

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Official Symbol
Ptpn21provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 21provided by RGD
Primary source
RGD:620216
See related
EnsemblRapid:ENSRNOG00000060568 AllianceGenome:RGD:620216
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ptp2E
Summary
Enables protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 99.0), Kidney (RPKM 65.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123662783..123727809, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (117933066..117998095, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122656500..122721496, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene spermatogenesis associated 7 Neighboring gene uncharacterized LOC134479245 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene EMAP like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway. Cui N, et al. Eur J Pharmacol, 2017 Nov 5. PMID 28843827
  2. Identification of a novel protein tyrosine phosphatase with sequence homology to the cytoskeletal proteins of the band 4.1 family. L'Abbé D, et al. FEBS Lett, 1994 Dec 19. PMID 7805871
  3. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Cardone L, et al. Mol Cell Biol, 2004 Jun. PMID 15143158, Free PMC Article
  4. Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. Bailey MJ, et al. J Biol Chem, 2009 Mar 20. PMID 19103603, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway
    Title: PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway.
  2. Expression of Ptpn21 decreases 8-fold at night in the rat pineal gland relative to day values. This appears to reflect negative effects of norepinephrine acting through a cyclic AMP mechanism.
    Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 21
Names
protein-tyrosine phosphatase 2E
NP_598229.2
XP_017449512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133545.2 → NP_598229.2  tyrosine-protein phosphatase non-receptor type 21

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q62728, Q62732
    UniProtKB/TrEMBL
    A0A0G2JTB7
    Related
    ENSRNOP00000068645.1, ENSRNOT00000079697.3
    Conserved Domains (4) summary
    smart00295
    Location:24 → 222
    B41; Band 4.1 homologues
    cd13188
    Location:217 → 307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd17192
    Location:20 → 106
    FERM_F1_PTPN21; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 21 (PTPN21) and similar proteins
    cl28904
    Location:884 → 1170
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    123662783..123727809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594023.3 → XP_017449512.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    UniProtKB/Swiss-Prot
    Q62728, Q62732
    UniProtKB/TrEMBL
    A0A0G2JTB7
    Conserved Domains (4) summary
    smart00295
    Location:24 → 222
    B41; Band 4.1 homologues
    cd13188
    Location:217 → 307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd17192
    Location:20 → 106
    FERM_F1_PTPN21; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 21 (PTPN21) and similar proteins
    cl28904
    Location:884 → 1170
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62728.1 GenPept UniProtKB/Swiss-Prot:Q62728

Gene LinkOut

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