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Nat8b N-acetyltransferase 8B [ Rattus norvegicus (Norway rat) ]

Gene ID: 171084, updated on 18-Sep-2024

Summary

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Symbol
Nat8bprovided by RGD
Full Name
N-acetyltransferase 8Bprovided by RGD
Primary source
RGD:621605
See related
EnsemblRapid:ENSRNOG00000056962 AllianceGenome:RGD:621605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cml1; Cml6; Nat8; RGD621605
Summary
Predicted to enable lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Predicted to be involved in several processes, including amyloid-beta metabolic process; negative regulation of apoptotic process; and peptidyl-lysine N6-acetylation. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 708.6), Liver (RPKM 50.1) and 5 other tissues See more
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Genomic context

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See Nat8b in Genome Data Viewer
Location:
4q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119916909..119923544, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118359445..118364351, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (117606022..117607366, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 1 Neighboring gene Tp53rk binding protein Neighboring gene dual specificity phosphatase 11 Neighboring gene uncharacterized LOC102549328

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. Ko MH, et al. J Biol Chem, 2009 Jan 23. PMID 19011241, Free PMC Article
  2. Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. Mak AB, et al. J Mol Biol, 2014 May 29. PMID 24556617, Free PMC Article
  3. Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Popsueva AE, et al. Dev Biol, 2001 Jun 15. PMID 11397015
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Clone Names

  • MGC93215

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyltransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in gastrulation with mouth forming second NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine N6-acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
probable N-acetyltransferase 8B
Names
camello-like 1 like
camello-like protein 1
camello-like protein 6
probable N-acetyltransferase CML6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133558.2 → NP_598242.1  probable N-acetyltransferase 8B

    See identical proteins and their annotated locations for NP_598242.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q9JIY6
    UniProtKB/TrEMBL
    A6IAU4
    Related
    ENSRNOP00000068791.1, ENSRNOT00000088557.3
    Conserved Domains (1) summary
    pfam00583
    Location:91 → 193
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    119916909..119923544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106980.2 → XP_038962908.1  probable N-acetyltransferase 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9JIY6
    UniProtKB/TrEMBL
    A6IAU4
    Conserved Domains (1) summary
    pfam00583
    Location:91 → 193
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. XM_008763107.4 → XP_008761329.1  probable N-acetyltransferase 8B isoform X1

    See identical proteins and their annotated locations for XP_008761329.1

    UniProtKB/Swiss-Prot
    Q9JIY6
    UniProtKB/TrEMBL
    A6IAU4
    Related
    ENSRNOP00000078918.1, ENSRNOT00000096643.2
    Conserved Domains (1) summary
    pfam00583
    Location:91 → 193
    Acetyltransf_1; Acetyltransferase (GNAT) family

  3. XM_017593010.3 → XP_017448499.1  probable N-acetyltransferase 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9JIY6
    UniProtKB/TrEMBL
    A6IAU4
    Conserved Domains (1) summary
    pfam00583
    Location:91 → 193
    Acetyltransf_1; Acetyltransferase (GNAT) family

  4. XM_008763105.4 → XP_008761327.1  probable N-acetyltransferase 8B isoform X1

    See identical proteins and their annotated locations for XP_008761327.1

    UniProtKB/Swiss-Prot
    Q9JIY6
    UniProtKB/TrEMBL
    A6IAU4
    Conserved Domains (1) summary
    pfam00583
    Location:91 → 193
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIY6.1 GenPept UniProtKB/Swiss-Prot:Q9JIY6

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