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Chrnb3 cholinergic receptor nicotinic beta 3 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 171131, updated on 2-Nov-2024

Summary

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Official Symbol
Chrnb3provided by RGD
Official Full Name
cholinergic receptor nicotinic beta 3 subunitprovided by RGD
Primary source
RGD:621544
See related
EnsemblRapid:ENSRNOG00000012448 AllianceGenome:RGD:621544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables acetylcholine binding activity. Contributes to heterocyclic compound binding activity. Predicted to be involved in several processes, including presynaptic modulation of chemical synaptic transmission; response to nicotine; and synaptic signaling. Part of acetylcholine-gated channel complex. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; cocaine dependence; depressive disorder; and nicotine dependence. Orthologous to human CHRNB3 (cholinergic receptor nicotinic beta 3 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 11.5), Brain (RPKM 4.1) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Chrnb3 in Genome Data Viewer
Location:
16q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (71411847..71454225, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (64713438..64751360, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (68876442..68913628, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene POTE ankyrin domain family, member G Neighboring gene cholinergic receptor nicotinic alpha 6 subunit Neighboring gene ribosomal protein L13A, pseudogene 8 Neighboring gene testis expressed gene 24 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Beta 3: a new member of nicotinic acetylcholine receptor gene family is expressed in brain. Deneris ES, et al. J Biol Chem, 1989 Apr 15. PMID 2703489
  2. Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia. Shi J, et al. EC Psychol Psychiatr, 2021. PMID 34368810, Free PMC Article
  3. The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. Cui C, et al. J Neurosci, 2003 Dec 3. PMID 14657161, Free PMC Article
  4. Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: high densities of receptors containing alpha6 and beta3 subunits. Cox BC, et al. J Neurochem, 2008 Jun. PMID 18266937
  5. CHRNB3 c.-57A>G functional promoter change affects Parkinson's disease and smoking. Bar-Shira A, et al. Neurobiol Aging, 2014 Sep. PMID 24731518

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the affinity of alpha-CTxLvIA selectively blocks alpha3beta2 vs. alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors.
    Title: A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors.
  2. Positional scanning mutagenesis of alpha-conotoxin PeIA identifies critical residues that confer potency and selectivity for alpha6/alpha3beta2beta3 and alpha3beta2 nicotinic acetylcholine receptors
    Title: Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.
  3. The concentration of beta3- and alpha6- containing neuronal nicotinic acetylcholine receptors (nAChRs) is higher in the optic nerve than in any other area of the rat brain.
    Title: Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: high densities of receptors containing alpha6 and beta3 subunits.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylcholine binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IC
Inferred by Curator
more info
 PubMed 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to heterocyclic compound binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nicotine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetylcholine-gated channel complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in dopaminergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neuronal acetylcholine receptor subunit beta-3
Names
cholinergic receptor, nicotinic beta 3
cholinergic receptor, nicotinic, beta 3 (neuronal)
cholinergic receptor, nicotinic, beta polypeptide 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133597.2 → NP_598281.1  neuronal acetylcholine receptor subunit beta-3 precursor

    See identical proteins and their annotated locations for NP_598281.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P12391
    UniProtKB/TrEMBL
    A6IVW9, Q6PW48
    Related
    ENSRNOP00000016656.3, ENSRNOT00000016656.6
    Conserved Domains (3) summary
    TIGR00860
    Location:29 → 455
    LIC; Cation transporter family protein
    pfam02931
    Location:35 → 239
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:246 → 452
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    71411847..71454225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094179.2 → XP_038950107.1  neuronal acetylcholine receptor subunit beta-3 isoform X1

    UniProtKB/TrEMBL
    Q6PW48
    Conserved Domains (1) summary
    TIGR00860
    Location:1 → 375
    LIC; Cation transporter family protein

  2. XM_039094178.2 → XP_038950106.1  neuronal acetylcholine receptor subunit beta-3 isoform X2

    Conserved Domains (1) summary
    TIGR00860
    Location:1 → 320
    LIC; Cation transporter family protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12391.1 GenPept UniProtKB/Swiss-Prot:P12391

Gene LinkOut

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