U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Camk2g calcium/calmodulin-dependent protein kinase II gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 171140, updated on 2-Nov-2024

Summary

Symbol
Camk2gprovided by RGD
Full Name
calcium/calmodulin-dependent protein kinase II gammaprovided by RGD
Primary source
RGD:621802
See related
EnsemblRapid:ENSRNOG00000009783 AllianceGenome:RGD:621802
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including protein autophosphorylation; regulation of protein localization to plasma membrane; and response to hypoxia. Is active in glutamatergic synapse and postsynaptic cytosol. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human CAMK2G (calcium/calmodulin dependent protein kinase II gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 299.9), Muscle (RPKM 278.6) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Camk2g in Genome Data Viewer
Location:
15p16
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3553238..3612310)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3504017..3563050)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (3936721..3995740)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096900 Neighboring gene plasminogen activator, urokinase Neighboring gene uncharacterized LOC108352872 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene zinc finger, SWIM-type containing 8 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium/calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of long-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of calcium- and calmodulin-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit gamma
Names
Ca+2/calmodulin-dependent protein kinase II gamma
caM kinase II subunit gamma
caM-kinase II gamma chain
caMK-II subunit gamma
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
calcium/calmodulin-dependent protein kinase type II gamma chain
calcium/calmodulin-dependent protein kinase type II subunit gamma-like
NP_598289.1
XP_008768708.1
XP_008768709.1
XP_008768710.1
XP_008768711.1
XP_008768712.1
XP_008768713.1
XP_008768714.1
XP_008768715.1
XP_008768716.1
XP_008768717.1
XP_008768718.1
XP_008768719.1
XP_008768720.1
XP_008768721.1
XP_017455064.1
XP_017455065.1
XP_017455066.1
XP_038948899.1
XP_038948900.1
XP_063130002.1
XP_063130003.1
XP_063130004.1
XP_063130005.1
XP_063130006.1
XP_063130007.1
XP_063130008.1
XP_063130009.1
XP_063130010.1
XP_063130011.1
XP_063130012.1
XP_063130013.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133605.1NP_598289.1  calcium/calmodulin-dependent protein kinase type II subunit gamma

    See identical proteins and their annotated locations for NP_598289.1

    Status: PROVISIONAL

    Source sequence(s)
    J04063
    UniProtKB/Swiss-Prot
    P11730, Q64003, Q64004
    UniProtKB/TrEMBL
    A0A8I5ZX06
    Related
    ENSRNOP00000088587.2, ENSRNOT00000107544.2
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:395522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    3553238..3612310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599577.3XP_017455066.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X17

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:374501
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. XM_008770489.4XP_008768711.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3

    See identical proteins and their annotated locations for XP_008768711.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:435562
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. XM_008770496.4XP_008768718.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12

    See identical proteins and their annotated locations for XP_008768718.1

    UniProtKB/TrEMBL
    A0A8I5Y738, A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:397524
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. XM_017599576.3XP_017455065.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:412539
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. XM_063273932.1XP_063130002.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZV59
  6. XM_008770491.4XP_008768713.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5

    See identical proteins and their annotated locations for XP_008768713.1

    UniProtKB/TrEMBL
    A0A8I5ZV59, A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:424551
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. XM_063273936.1XP_063130006.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14

  8. XM_008770497.4XP_008768719.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14

    See identical proteins and their annotated locations for XP_008768719.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Related
    ENSRNOP00000077055.2, ENSRNOT00000120116.2
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  9. XM_008770495.4XP_008768717.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11

    See identical proteins and their annotated locations for XP_008768717.1

    UniProtKB/TrEMBL
    A0A8I6A5E2, A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:401528
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  10. XM_063273938.1XP_063130008.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X18

  11. XM_008770499.4XP_008768721.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X18

    See identical proteins and their annotated locations for XP_008768721.1

    UniProtKB/TrEMBL
    A0A8I5ZX06
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:363490
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  12. XM_039092972.2XP_038948900.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

    Conserved Domains (1) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  13. XM_008770487.4XP_008768709.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_008768709.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:456583
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  14. XM_008770486.4XP_008768708.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_008768708.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Related
    ENSRNOP00000062321.4, ENSRNOT00000066163.6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:456583
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  15. XM_063273933.1XP_063130003.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

  16. XM_008770490.4XP_008768712.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4

    See identical proteins and their annotated locations for XP_008768712.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:433560
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  17. XM_008770488.4XP_008768710.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2

    See identical proteins and their annotated locations for XP_008768710.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:445572
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  18. XM_008770492.4XP_008768714.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

    See identical proteins and their annotated locations for XP_008768714.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:422549
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  19. XM_008770493.4XP_008768715.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

    See identical proteins and their annotated locations for XP_008768715.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:418545
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  20. XM_063273934.1XP_063130004.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10

  21. XM_008770494.4XP_008768716.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10

    See identical proteins and their annotated locations for XP_008768716.1

    UniProtKB/TrEMBL
    A0A8I6AC70
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:407534
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  22. XM_008770498.4XP_008768720.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15

    See identical proteins and their annotated locations for XP_008768720.1

    UniProtKB/TrEMBL
    A0A8I5ZX06, A0A8I6AD45
    Related
    ENSRNOP00000090198.1, ENSRNOT00000114050.2
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:384511
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  23. XM_063273940.1XP_063130010.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X20

  24. XM_063273939.1XP_063130009.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X19

  25. XM_063273942.1XP_063130012.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X21

  26. XM_063273935.1XP_063130005.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13

  27. XM_063273937.1XP_063130007.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X16

    Related
    ENSRNOP00000111753.1, ENSRNOT00000135346.1
  28. XM_063273941.1XP_063130011.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X20

  29. XM_017599575.3XP_017455064.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8

    UniProtKB/TrEMBL
    A0A8I6AC70
  30. XM_039092971.1XP_038948899.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X22

    Conserved Domains (2) summary
    pfam08332
    Location:234361
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain
  31. XM_063273943.1XP_063130013.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X23

RNA

  1. XR_010057798.1 RNA Sequence

  2. XR_010057800.1 RNA Sequence

  3. XR_010057797.1 RNA Sequence

  4. XR_001841253.3 RNA Sequence

  5. XR_010057799.1 RNA Sequence

  6. XR_010057801.1 RNA Sequence