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Gpha2 glycoprotein hormone subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171158, updated on 2-Nov-2024

Summary

Official Symbol
Gpha2provided by RGD
Official Full Name
glycoprotein hormone subunit alpha 2provided by RGD
Primary source
RGD:621748
See related
EnsemblRapid:ENSRNOG00000021020 AllianceGenome:RGD:621748
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpa2; Zsig51
Summary
Predicted to enable protein heterodimerization activity and thyrotropin-releasing hormone receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human GPHA2 (glycoprotein hormone subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 8.7), Thymus (RPKM 7.3) and 9 other tissues See more
Orthologs
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Genomic context

See Gpha2 in Genome Data Viewer
Location:
1q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212954579..212956536)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203525952..203527271)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221594110..221597297)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene basic leucine zipper ATF-like transcription factor 2 Neighboring gene membrane anchored junction protein Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene autophagy related 2A Neighboring gene microRNA 194-2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables thyrotropin-releasing hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thyrotropin-releasing hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glycoprotein hormone alpha-2
Names
cysteine knot protein
glycoprotein hormone alpha 2
glycoprotein-alpha 2
putative secreted protein ZSIG51
thyrostimulin subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133619.2NP_598303.1  glycoprotein hormone alpha-2 precursor

    See identical proteins and their annotated locations for NP_598303.1

    Status: PROVISIONAL

    Source sequence(s)
    AF260741
    UniProtKB/Swiss-Prot
    Q925Q4
    UniProtKB/TrEMBL
    A0A0F7RPV4
    Related
    ENSRNOP00000028536.2, ENSRNOT00000028536.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212954579..212956536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275625.1XP_063131695.1  glycoprotein hormone alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    Q925Q4
    UniProtKB/TrEMBL
    A0A0F7RPV4
  2. XM_063275585.1XP_063131655.1  glycoprotein hormone alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    Q925Q4
    UniProtKB/TrEMBL
    A0A0F7RPV4
  3. XM_063275540.1XP_063131610.1  glycoprotein hormone alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    Q925Q4
    UniProtKB/TrEMBL
    A0A0F7RPV4