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Zhx1 zinc fingers and homeoboxes 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171159, updated on 10-Oct-2024

Summary

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Official Symbol
Zhx1provided by RGD
Official Full Name
zinc fingers and homeoboxes 1provided by RGD
Primary source
RGD:620010
See related
EnsemblRapid:ENSRNOG00000006412 AllianceGenome:RGD:620010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables DNA binding activity. Involved in regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human ZHX1 (zinc fingers and homeoboxes 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 168.2), Brain (RPKM 158.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zhx1 in Genome Data Viewer
Location:
7q33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (91472193..91501984, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89582363..89611337, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97915280..97944787, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093813 Neighboring gene similar to human chromosome 8 open reading frame 76 Neighboring gene ribosomal protein S10, pseudogene 16 Neighboring gene ATPase family, AAA domain containing 2 Neighboring gene uncharacterized LOC134479909

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). Yamada K, et al. Biochem Biophys Res Commun, 2002 Sep 20. PMID 12237128
  2. Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. Hirano S, et al. Gene, 2002 May 15. PMID 12062805
  3. Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. Kim SH, et al. Biochem Biophys Res Commun, 2007 Apr 6. PMID 17303076
  4. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. Kawata H, et al. Biochem J, 2003 Aug 1. PMID 12741956, Free PMC Article
  5. Early changes in gene expression that influence the course of primary glomerular disease. Clement LC, et al. Kidney Int, 2007 Aug. PMID 17457373

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc fingers and homeoboxes protein 1
Names
zinc finger and homeodomain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133620.2 → NP_598304.2  zinc fingers and homeoboxes protein 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q8R515
    UniProtKB/TrEMBL
    A6HRJ3, G3V6S9
    Conserved Domains (4) summary
    smart00389
    Location:665 → 716
    HOX; Homeodomain
    cd00086
    Location:468 → 523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785 → 821
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:98 → 150
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    91472193..91501984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594644.3 → XP_017450133.1  zinc fingers and homeoboxes protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8R515
    UniProtKB/TrEMBL
    A6HRJ3, G3V6S9
    Related
    ENSRNOP00000079266.1, ENSRNOT00000100253.2
    Conserved Domains (4) summary
    smart00389
    Location:665 → 716
    HOX; Homeodomain
    cd00086
    Location:468 → 523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785 → 821
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:98 → 150
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  2. XM_063262951.1 → XP_063119021.1  zinc fingers and homeoboxes protein 1 isoform X1

    UniProtKB/TrEMBL
    A6HRJ3, G3V6S9
    Related
    ENSRNOP00000008454.2, ENSRNOT00000008454.6

  3. XM_017594643.3 → XP_017450132.1  zinc fingers and homeoboxes protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8R515
    UniProtKB/TrEMBL
    A6HRJ3, G3V6S9
    Related
    ENSRNOP00000084155.1, ENSRNOT00000112281.2
    Conserved Domains (4) summary
    smart00389
    Location:665 → 716
    HOX; Homeodomain
    cd00086
    Location:468 → 523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785 → 821
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:98 → 150
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  4. XM_063262952.1 → XP_063119022.1  zinc fingers and homeoboxes protein 1 isoform X1

    UniProtKB/TrEMBL
    A6HRJ3, G3V6S9
    Related
    ENSRNOP00000081548.1, ENSRNOT00000117985.2

RNA

  1. XR_010052934.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R515.1 GenPept UniProtKB/Swiss-Prot:Q8R515

Gene LinkOut

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