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Clk3 CDC-like kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171305, updated on 2-Nov-2024

Summary

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Official Symbol
Clk3provided by RGD
Official Full Name
CDC-like kinase 3provided by RGD
Primary source
RGD:621259
See related
EnsemblRapid:ENSRNOG00000030126 AllianceGenome:RGD:621259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein kinase activity. Predicted to be involved in protein phosphorylation and regulation of RNA splicing. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Predicted to be located in intermediate filament cytoskeleton and nucleoplasm. Orthologous to human CLK3 (CDC like kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 119.0), Spleen (RPKM 107.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Clk3 in Genome Data Viewer
Location:
8q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67048121..67063192, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58152155..58167196, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62528135..62543550, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 1 Neighboring gene U6 spliceosomal RNA Neighboring gene enhancer of mRNA decapping 3 Neighboring gene single stranded DNA binding protein 1, pseudogene 4 Neighboring gene AT-rich interaction domain 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA cloning and characterization of rat Clk3, a LAMMER kinase predominately expressed in testis. Becker W, et al. Biochim Biophys Acta, 1996 Jun 5. PMID 8679717
  2. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. Ma X, et al. In Vitro Cell Dev Biol Anim, 2024 Apr. PMID 38438604
  3. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Duncan PI, et al. Exp Cell Res, 1998 Jun 15. PMID 9637771
  4. Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. Nayler O, et al. Biochem J, 1997 Sep 15. PMID 9307018, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway.
    Title: CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dual specificity protein kinase CLK3
NP_599167.2
XP_006243208.1
XP_038936675.1
XP_063120894.1
XP_063120895.1
XP_063120896.1
XP_063120897.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134340.2 → NP_599167.2  dual specificity protein kinase CLK3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q63117, Q6IRK2
    UniProtKB/TrEMBL
    A0A8I6GM85, A6J4X9
    Conserved Domains (1) summary
    cd14214
    Location:142 → 472
    PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    67048121..67063192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243146.5 → XP_006243208.1  dual specificity protein kinase CLK3 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UQV5
    Related
    ENSRNOP00000061691.3, ENSRNOT00000068108.4
    Conserved Domains (2) summary
    PHA03247
    Location:29 → 162
    PHA03247; large tegument protein UL36; Provisional
    cd14214
    Location:292 → 622
    PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

  2. XM_063264827.1 → XP_063120897.1  dual specificity protein kinase CLK3 isoform X2

    UniProtKB/Swiss-Prot
    Q63117, Q6IRK2
    UniProtKB/TrEMBL
    A6J4X9

  3. XM_063264825.1 → XP_063120895.1  dual specificity protein kinase CLK3 isoform X2

    UniProtKB/Swiss-Prot
    Q63117, Q6IRK2
    UniProtKB/TrEMBL
    A6J4X9

  4. XM_063264824.1 → XP_063120894.1  dual specificity protein kinase CLK3 isoform X2

    UniProtKB/Swiss-Prot
    Q63117, Q6IRK2
    UniProtKB/TrEMBL
    A6J4X9

  5. XM_039080747.2 → XP_038936675.1  dual specificity protein kinase CLK3 isoform X2

    UniProtKB/Swiss-Prot
    Q63117, Q6IRK2
    UniProtKB/TrEMBL
    A0A8I6GM85, A6J4X9
    Conserved Domains (1) summary
    cd14214
    Location:142 → 472
    PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

  6. XM_063264826.1 → XP_063120896.1  dual specificity protein kinase CLK3 isoform X2

    UniProtKB/Swiss-Prot
    Q63117, Q6IRK2
    UniProtKB/TrEMBL
    A6J4X9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63117.2 GenPept UniProtKB/Swiss-Prot:Q63117

Gene LinkOut

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