Gprasp1 G protein-coupled receptor associated sorting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gprasp1provided by RGD
Official Full Name: G protein-coupled receptor associated sorting protein 1provided by RGD
Primary source: RGD:621343
See related: EnsemblRapid:ENSRNOG00000049985 AllianceGenome:RGD:621343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: pips
Summary: Predicted to be involved in G protein-coupled receptor catabolic process and endosome to lysosome transport. Predicted to be active in cytosol and nucleus. Orthologous to human GPRASP1 (G protein-coupled receptor associated sorting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 532.1), Adrenal (RPKM 81.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (103556493..103564275)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (98764853..98772685)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (106306795..106313904)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Per1 gene product in the rat suprachiasmatic nucleus is modulated by seasonal changes in daylength.
Title: The circadian rhythm of Per1 gene product in the rat suprachiasmatic nucleus and its modulation by seasonal changes in daylength.
Ca(2+)/cAMP response element-binding protein (CREB) and Per1 are integral components of the pathway transducing light-stimulated GLU neurotransmission into phase advance of the circadian clock
Title: Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock.
nuclear translocation of PIPS is involved in NGF mediated neuronal survival via TrkA, PI3K, and Gab1 signaling pathway
Title: Role of Per1-interacting protein of the suprachiasmatic nucleus in NGF mediated neuronal survival.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptor-associated sorting protein 1

Names: GASP-1; Per1 interacting protein; per1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134386.2 → NP_599213.2 G-protein coupled receptor-associated sorting protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q920R4

UniProtKB/TrEMBL

A6KT36, M0R9R0

Related

ENSRNOP00000066239.1, ENSRNOT00000073661.4

Conserved Domains (1) summary

pfam04826
Location:1096 → 1341

Arm_2; Armadillo-like