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Aagab alpha- and gamma-adaptin binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 171435, updated on 2-Nov-2024

Summary

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Official Symbol
Aagabprovided by RGD
Official Full Name
alpha- and gamma-adaptin binding proteinprovided by RGD
Primary source
RGD:621601
See related
EnsemblRapid:ENSRNOG00000008424 AllianceGenome:RGD:621601
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P34
Summary
Predicted to be involved in protein transport. Predicted to be located in cytosol and nuclear speck. Human ortholog(s) of this gene implicated in punctate palmoplantar keratoderma type I. Orthologous to human AAGAB (alpha and gamma adaptin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 175.4), Spleen (RPKM 158.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aagab in Genome Data Viewer
Location:
8q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (72978719..73017275)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64083343..64121903)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (68526063..68564604)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547003 Neighboring gene 60S ribosomal protein L37-like Neighboring gene IQ motif containing H Neighboring gene uncharacterized LOC134480189 Neighboring gene SMAD family member 3 Neighboring gene SMAD family member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of distinct mutations in AAGAB in families with type 1 punctate palmoplantar keratoderma. Furniss M, et al. J Invest Dermatol, 2014 Jun. PMID 24390136, Free PMC Article
  2. Aftiphilin is a component of the clathrin machinery in neurons. Burman JL, et al. FEBS Lett, 2005 Apr 11. PMID 15811338
  3. Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage. Dai C, et al. Cell Death Differ, 2021 Aug. PMID 33712741, Free PMC Article
  4. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. Page LJ, et al. J Cell Biol, 1999 Sep 6. PMID 10477754, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha- and gamma-adaptin-binding protein p34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134398.2 → NP_599225.1  alpha- and gamma-adaptin-binding protein p34

    See identical proteins and their annotated locations for NP_599225.1

    Status: PROVISIONAL

    Source sequence(s)
    AF178669
    UniProtKB/Swiss-Prot
    Q9R0Z7
    UniProtKB/TrEMBL
    A0A8I6AEU2, A6J5A2
    Conserved Domains (1) summary
    pfam10199
    Location:155 → 294
    Adaptin_binding; Alpha and gamma adaptin binding protein p34

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    72978719..73017275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264883.1 → XP_063120953.1  alpha- and gamma-adaptin-binding protein p34 isoform X1

  2. XM_063264884.1 → XP_063120954.1  alpha- and gamma-adaptin-binding protein p34 isoform X2

  3. XM_006243223.4 → XP_006243285.1  alpha- and gamma-adaptin-binding protein p34 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AEU2
    Related
    ENSRNOP00000011385.4, ENSRNOT00000011385.6
    Conserved Domains (1) summary
    pfam10199
    Location:155 → 293
    Adaptin_binding; Alpha and gamma adaptin binding protein p34
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0Z7.1 GenPept UniProtKB/Swiss-Prot:Q9R0Z7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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